Organization profile

Organisation profile

The Centre focuses on physiological, psychological and biomechanical aspects of physical activity interventions in sedentary, active and clinical populations, and the microbiological, genetic and molecular aspects of disease progression to target national and global challenges to health.

The Research Centre aims to:

  • Bring together researchers examining physiological, psychological and biomechanical aspects of physical activity interventions in sedentary, active and clinical populations, and the microbiological, genetic and molecular aspects of disease progression.
  • Develop research capacity by providing training for undergraduate to postdoctoral researchers and supporting early career researchers to become independent research leaders targeting national and global challenges to health.

The Centre for Physical Activity and Life Sciences is a multidisciplinary Centre including expertise in Biosciences, Sport & Exercise Sciences, Podiatry, and Occupational Therapy.  The Centre includes two main Research Groups (Molecular Biosciences Research Group, Neuromuscular and Musculoskeletal Research Group) with the main interests of researchers in these Groups outlined below:

  • Molecular Biosciences Research Group
    • Immunogenetics
    • Clinical genetics and genomics
    • RNA-based gene therapy
    • Cancer biology
    • Neuromuscular and neurodegenerative disorders
    • Monozygotic twin studies
    • Bioethics
    • Antimicrobial resistance
    • Molecular Mechanisms of Bacterial Pathogenesis
    • Infection control
  • Neuromuscular and Musculoskeletal Research Group
    • Functional decline during ageing and fall risk
    • Sarcopenia and osteoporosis
    • Eccentric exercise in healthy and ageing populations
    • Cognitive impairment, pain and balance in ageing
    • Muscle stretching techniques and strain injury
    • Isometric resistance training and hypertension
    • Exercise-induced muscle damage
    • Heat- and cryo-based therapy
    • Stroke rehabilitation
    • Concussion in impact sports

Fingerprint Dive into the research topics where Centre for Physical Activity and Life Sciences is active. These topic labels come from the works of this organisation's members. Together they form a unique fingerprint.

  • Network Recent external collaboration on country level. Dive into details by clicking on the dots.

    Projects

    Research Output

    The External Validity of a Novel Contract-Relax Stretching Technique on Knee Flexor Range of Motion

    Kay, A. D., Dixon, J., Bligh, L. D. & Blazevich, A. J., 1 Jan 2020, In : Scandinavian Journal Of Medicine & Science in Sports. 30, 1, p. 74-82 9 p.

    Research output: Contribution to JournalArticle

    Open Access
  • A mutation in the major autophagy gene, WIPI2, associated with global developmental abnormalities

    Nasir, J., 10 Apr 2019, In : Brain. 142, 5, p. 1242-1254 13 p.

    Research output: Contribution to JournalArticle

    Open Access
  • Arterial stiffness is a predictor for acute kidney injury following coronary artery bypass graft surgery

    Greenwood, S. A., Mangahis, E., Castle, E. M., Wang, J., Campbell, J., Deshpande, R. & Jayawardene, S., 7 Mar 2019, In : Journal of Cardiothoracic Surgery. 14, 1, p. 51 5 p.

    Research output: Contribution to JournalArticle

    Open Access
    File
  • Activities

    PhD thesis

    Lee Machado (Examiner)
    16 Dec 2019

    Activity: ExaminationsExaminationResearch

    Induction of inflammasome-dependent signalling in the human monocytic cell line THP-1 by Campylobacter lipooligosaccharides

    Alexandra Woodacre (Speaker)
    11 Apr 2019

    Activity: Academic Talks or PresentationsOral presentationResearch

    BBC

    Wanda McCormick (Visiting researcher)
    17 May 2019

    Activity: Public Engagement and OutreachParticipating in a Television or Radio Show

    Impacts

    FDA approves first drug to treat Duchenne muscular dystrophy (DMD)

    Karen Anthony (Co-Investigator)

    Impact: Public policy impacts, Health and Well-Being impacts, Quality of life impacts, 03: Good Health and Well-Being (UN SDG)

    Student theses

    Characterisation of the Lipooligosaccharide biosynthesis gene cluster in Campylobacter species.

    Author: Hameed, A., 30 Oct 2019

    Supervisor: Machado, L. (Supervisor), Marsden, G. L. (External person) (Supervisor) & Woodacre, A. (Supervisor)

    Student thesis: Doctoral Thesis

    Characterising the Role of the Calcium-dependent Citrullinating Enzyme Peptidyl Arginine Deiminase 2 in Ovarian Cancer

    Author: Albalbeisi, N., Oct 2019

    Supervisor: Livingstone, I. (Supervisor), Machado, L. (Supervisor) & Anthony, K. (Supervisor)

    Student thesis: Doctoral Thesis

    Obesity as a modulator of tumour microenvironment and anti-tumour responses in a mouse model

    Author: Oday Hessian Al-Zubaidi, R., 9 Dec 2019

    Supervisor: Stover, C. (External person) (Supervisor) & Machado, L. (Supervisor)

    Student thesis: Doctoral Thesis