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20032020

Research output per year

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Research Output

2020

An Updated Classification System and Review of the Lipooligosaccharide Biosynthesis Gene Locus in Campylobacter jejuni

Machado, L., Woodacre, A., Hameed, A. & Marsden, G. L., 19 May 2020, In : Frontiers in Microbiology. 11, 677, p. 1-11 11 p.

Research output: Contribution to JournalReview Article

Open Access
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2018

High fat diet induced obesity modulates melanoma tumour microenvironment in low density lipoprotein receptor deficient LDLR-/- mouse model.

Al-Zubaidi, R., Stover, C. & Machado, L. R., 13 Sep 2018, p. 90. 1 p.

Research output: Contribution to ConferenceAbstract

Open Access
Open Access
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Targeting gp100 and TRP-2 with a DNA vaccine: incorporating T cell epitopes with a human IgG1 antibody induces potent T cell responses that are associated with favourable clinical outcome in a phase I/II trial

Patel, P. M., Ottensmeier, C., Mulatero, C., Lorigan, P., Plummer, R., Pandha, H., Elsheik, S., Hadjimichael, E., Villasanti, N., Adams, S. E., Cunnell, M., Metheringham, R. L., Brentville, V. A., Machado, L., Daniels, I., Gijon, M., Hannaman, D. & Durrant, L. G., 22 Feb 2018, In : OncoImmunology. 7, 6, 15 p., e1433516.

Research output: Contribution to JournalArticle

Open Access
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2017

Abstract 9035: An adjuvant clinical trial of SCIB1, a DNA vaccine that targets dendritic cells in vivo, in fully resected melanoma patients

Patel, P. M., Ottensmeier, C., Mulatero, C., Lorigan, P., Plummer, R., Hannaman, D., Cunnell, M., Metheringham, R. L., Brentville, V. A., Daniels, I., Machado, L. & Durrant, L. G., 31 Jan 2017.

Research output: Contribution to ConferenceAbstract

Health and wellbeing amongst older people research in Northamptonshire

Poole, H., Sixsmith, J., Parkes, J., Ward, A., Pyer, M., Campbell, J., Machado, L., Rehling, T., Youell, J., Carter, J., Oyebode, J., O’Malley, M., Anthony, K., Rogers, S., Jones, J., Siddons, L., Smith, L-A., Kay, A. D., Fraser, M., Score, J. & 8 others, El Khoury, L., Hameed, A., Albalbeisi, N., Durrant, L. G., Al-Zubaidi, R., Al-Rayahi, I., da Silva, K. & Taylor, J., 1 Aug 2017, (East Midlands Research into Ageing Network (EMRAN) Discussion Paper Series).

Research output: Working PaperDiscussion Paper

Open Access
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High mobility group protein B1 is a predictor of poor survival in ovarian cancer

Machado, L., Moseley, P. M., Moss, R., Deen, S., Nolan, C., Spendlove, I. & Ramage, J., 24 Nov 2017, In : Oncotarget. 8, 60, p. 101215-101223 9 p.

Research output: Contribution to JournalArticle

Open Access
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Population genetics of immune-related multilocus copy number variation in Native Americans

Zuccherato, L., Schneider, S., Tarazona-Santos, E., Hardwick, R. J., Berg, D., Bogle, H., Gouveia, M., Machado, L., Machado, M., Rodrigues-Soares, F., Soares-Souza, G., Togni, D., Zamudio, R., Gilman, R., Duarte, D., Hollox, E. J. & Rodrigues, M. R., 29 Mar 2017, In : Journal of the Royal Society Interface. 14, 128

Research output: Contribution to JournalArticle

Open Access
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2016

Downregulation of the citrullinating enzyme Peptidyl-arginine deiminase type-2 in ovarian cancer indicates poor prognosis

Machado, L., Moseley, P. M., Moss, R., Deen, S., Nolan, C., Spendlove, I., Ramage, J., Chan, S. & Durrant, L. G., 6 Nov 2016.

Research output: Contribution to ConferencePoster

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Understanding the genomic structure of copy number variants of the low-affinity Fcγ receptor region allows confirmation of the association of FCGR3B deletion with rheumatoid arthritis

Rahbari, R., Zuccherato, L. W., Tischler, G., Chihota, B., Ozturk, H., Saleem, S., Tarazona-Santos, E., Machado, L. & Hollox, E. J., 20 Dec 2016, In : Human Mutation. 38, 4, p. 390-399 10 p.

Research output: Contribution to JournalArticle

Open Access
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Understanding the genomic structure of copy number variants of the low-affinity Fcγ receptor region allows confirmation of the association of FCGR3B deletion with rheumatoid arthritis

Rahbari, R., Zuccherato, L., Tischler, G., Chihota, B., Tarazona-Santos, E., Machado, L. & Hollox, E. J., 6 Dec 2016.

Research output: Contribution to ConferenceAbstract

2015

A clinical trial of a DNA vaccine (SCIB1) that targets dendritic cells in vivo in fully resected melanoma patients; a vaccine to prevent disease recurrence?

Durrant, L. G., Ottensmeier, C. H., Mulatero, C., Lorigan, P., Plummer, R., Cunnell, M., Metheringham, R., Brentville, V., Machado, L., Daniels, I., Hannaman, D. & Patel, P. M., 6 Oct 2015.

Research output: Contribution to ConferenceAbstract

Open Access
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A Comparison of Assays for Accurate Copy Number Measurement of the Low-Affinity Fc Gamma Receptor Genes FCGR3A and FCGR3B

Haridan, U. S., Mokhtar, U., Machado, L., Abdul Aziz, A. T., Shueb, R. H., Zaid, M., Sim, B., Mustafa, M., Nik Yusof, N. K., Lee, C. K. C., Abu Bakar, S., AbuBakar, S., Hollox, E. J. & Boon Peng, H., 16 Jan 2015, In : PLoS ONE. 10, 1, p. 1-13 13 p.

Research output: Contribution to JournalArticle

Open Access
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Open Access
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Evaluation of high-throughput genomic assays for the Fc gamma receptor locus

Hargreaves, C. E., Iriyama, C., Rose-Zerilli, M. J. J., Nagelkerke, S. Q., Hussain, K., Ganderton, R., Lee, C., Machado, L., Hollox, E. J., Parker, H., Latham, K. V., Kuijpers, T. W., Potter, K. N., Coupland, S. E., Davies, A., Stackpole, M., Oates, M., Pettitt, A. R., Glennie, M. J., Cragg, M. S. & 1 others, Strefford, J. C., 6 Nov 2015, In : PLoS ONE. 10, 11, p. 1-13 13 p.

Research output: Contribution to JournalArticle

Open Access
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Fcγ receptors: genetic variation, function, and disease

Hargreaves, C. E., Rose-Zerilli, M. J. J., Machado, L., Iriyama, C., Hollox, E. J., Cragg, M. S. & Strefford, J. C., 26 Oct 2015, In : Immunological Reviews. 268, 1, p. 1-19 19 p.

Research output: Contribution to JournalArticle

Human Leukocyte Antigen (HLA) A*1101-restricted Epstein-Barr virus-specific T-cell receptor gene transfer to target Nasopharyngeal carcinoma

Zheng, Y., Parsonage, G., Zhuang, X., Machado, L., James, C., Salman, A., Searle, P., Hui, E. P., Chan, A. T. C. & Lee, S. P., 24 Feb 2015, In : Cancer Immunology Research. 3, 10, p. 1138-1146 9 p.

Research output: Contribution to JournalArticle

Open Access
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2014

Abstract CT331: Phase I/II trial of a novel antibody DNA immunotherapy, targeting CD64, in the treatment of Melanoma

Durrant, L. G., Ottensmeier, C., Lorigan, P., Mulatero, C., Plummer, R., Cunell, M., Metheringham, R. L., Brentville, V. A. & Machado, L., 1 Oct 2014.

Research output: Contribution to ConferenceAbstract

DNA vaccines

Durrant, L. G., Xue, L., Machado, L., Metheringham, R. L., Brentville, V. A. & Rees, R. C. (ed.), 29 May 2014, Tumor Immunology and Immunotherapy. Oxford: Oxford University Press, p. 251-264 14 p.

Research output: Contribution to Book/ReportChapter

Genomic dissection of the Fcγ receptor region in the context of monoclonal antibody therapy

Hargreaves, C., Iriyama, C., Rose-Zerilli, M., Lee, C., Potter, K., Ganderton, R., Hussain, K., Machado, L., Hollox, E. J., Coupland, S., Stackpole, M., Oates, M., Pettitt, A. R., Cragg, M. & Strefford, J., 6 Dec 2014.

Research output: Contribution to ConferenceAbstract

High-mobility group protein 1 (HMGB1) is an independent predictor of poor survival in ovarian cancer

Machado, L., Moseley, P., Moss, R., Nolan, C., Rampage, J., Chan, S. & Durrant, L. G., 1 Jan 2014.

Research output: Contribution to ConferenceAbstract

Phase I trial of ImmunoBody in melanoma patients

Patel, P. M., Durrant, L. G., Ottensmeier, C., Mulatero, C., Lorigan, P., Plummer, R., Cunnell, M., Metheringham, R. L., Brentville, V. A., Machado, L., Daniels, I. & Hannaman, D., 1 Jun 2014.

Research output: Contribution to ConferenceAbstract

Septicaemia models using Streptococcus pneumoniae and Listeria monocytogenes: understanding the role of complement properdin

Dupont, A., Mohamed, F., Salehen, NA., Glenn, S., Francescut, L., Adib, R., Byrne, S., Brewin, H., Elliott, I., Richards, L., Dimitrova, P., Schwaeble, W., Ivanovska, N., Kadioglu, A., Machado, L., Andrew, P. W. & Stover, C., 1 Aug 2014, In : Medical Microbiology and Immunology. 203, 4, p. 257–271 15 p.

Research output: Contribution to JournalArticle

Open Access
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2013

Copy number variation of Fc gamma receptor genes in HIV-infected and HIV-tuberculosis co-infected individuals in Sub-Saharan Africa

Machado, L., Bowdrey, J., Ngaimisi, E., Habtewold, A., Minzi, O., Makonnen, E., Yimer, G., Amogne, W., Mugusi, S., Janabi, M., Aderaye, G., Mugusi, F., Viskaduraki, M., Aklillu, E. & Hollox, E. J., 1 Nov 2013, In : PLoS ONE. 8, 11

Research output: Contribution to JournalArticle

Open Access
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2012

B-defensin genomic copy number is associated with HIV load and immune reconstitution in sub-Saharan Africans

Hardwick, R. J., Amogne, W., Mugusi, S., Yimer, G., Ngaimisi, E., Habtewold, A., Minzi, O., Makonnen, E., Janabi, M., Machado, L., Viskaduraki, M., Mugusi, F., Aderaye, G., Lindquist, L., Hollox, E. J. & Aklillu, E., 1 Oct 2012, In : The Journal of Infectious Diseases. 206, 7

Research output: Contribution to JournalArticle

Open Access

CXCR6 and CCR5 localize T lymphocyte subsets in nasopharyngeal carcinoma

Parsonage, G., Machado, L., Hui, J. W-Y., McLarnon, A., Schmaler, T., Balasothy, M., To, K-F., Vlantis, A. C., Hasselt, C. A. V., Lo, K-W., Wong, W-L., Hui, E. P., Cheung Chan, A. T. & Lee, S. P., 3 Mar 2012, In : American Journal of Pathology. 180, 3, p. 1215-1222 7 p.

Research output: Contribution to JournalArticle

Open Access

Evolutionary history of copy-number-variable locus for the low-affinity Fcy receptor: mutation rate, autoimmune disease, and the legacy of helminth infection

Machado, L., Hardwick, R. J., Bowdrey, J., Bogle, H., Knowles, T., Sironi, M. & Hollox, E. J., 8 Jun 2012, In : The American Journal of Human Genetics. 90, 6, p. 973-985 12 p.

Research output: Contribution to JournalArticle

Open Access
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2011

A worldwide analysis of beta-defensin copy number variation suggests recent selection of a high-expressing DEFB103 gene copy in East Asia

Hardwick, R. J., Machado, L., Zuccherato, L., Antolinos, S., Xue, Y., Shawa, N., Gilman, R., Cabrera, L., Berg, D., Tyler-Smith, C., Kelly, P., Tarazona-Santos, E. & Hollox, E. J., 1 Jul 2011, In : Human Mutation. 32, 7

Research output: Contribution to JournalArticle

β-Defensin genomic copy number is associated with HIV viral load and immune reconstitution in sub-Saharan Africans

Hardwick, R. J., Amogne, W., Mugusi, S., Yimer, G., Ngaimisi, E., Habtewold, A., Minzi, O., Makonnen, E., Janabi, M., Machado, L., Mugusi, F., Aderaye, G., Lindquist, L., Hollox, E. J. & Aklillu, E., 1 Dec 2011.

Research output: Contribution to ConferenceAbstract

2010

EBV-specific T cell receptor gene transfer to target nasopharyngeal carcinoma

Zheng, Y., Machado, L., Johnson, B., James, C., Parsonage, G. & Lee, S. P., 1 Jan 2010.

Research output: Contribution to ConferenceAbstract

T cell homing to nasopharyngeal carcinoma

Parsonage, G., Machado, L., Hui, J. W-Y., Schmaler, T. T., Balasothy, M., Van Hasselt, A., Vlantis, L., Hui, E. P., Chan, A. T. C., Lo, K-W. & Lee, S. P., 1 Jan 2010.

Research output: Contribution to ConferenceAbstract

2009

Deregulated expression of cytokine receptor gene, CRLF2, is involved in lymphoid transformation in B-cell precursor acute lymphoblastic leukemia

Russell, L., Capasso, M., Vater, I., Akasaka, T., Bernard, O., Calasanz, M. J., Chandrasekaran, T., Chapiro, E., Gesk, S., Griffiths, M., Guttery, D., Haferlach, C., Harder, L., Heidenreich, O., Irving, J., Kearney, L., Nguyen-Khac, F., Machado, L., Minto, L., Majid, A. & 9 others, Moorman, A., Morrison, H., Rand, V., Strefford, J., Schwab, C., Tonnies, H., Dyer, M., Siebert, R. & Harrison, C., 29 Jul 2009, In : Blood. 114, 13, p. 2688-2698 10 p.

Research output: Contribution to JournalArticle

Open Access

Expression and function of T cell homing molecules in Hodgkin’s lymphoma

Machado, L., Jarrett, R., Morgan, S., Murray, P., Hunter, B., Hamilton, E., Crocker, J., Thomas, W., Steven, N., Ismail, T., Chapman, A., Adams, D. H. & Lee, S. P., 1 Jan 2009, In : Cancer Immunology, Immunotherapy. 58, 1, p. 85–94 10 p.

Research output: Contribution to JournalArticle

Open Access

T cell receptor gene transfer to target the Epstein-Barr virus-associated malignancy nasopharyngeal carcinoma

Zheng, Y., Machado, L., Johnson, B., James, C., Parsonage, G. & Lee, S. P., 1 Jan 2009.

Research output: Contribution to ConferenceAbstract

2008

Expression of the Epstein-Barr virus-encoded Epstein-Barr virus nuclear antigen 1 in Hodgkin's Lymphoma cells mediates Up-regulation of CCL20 and the migration of regulatory T cells

Baumforth, K. R. N., Birgersdotter, A., Reynolds, G. M., Wei, W., Kapatai, G., Flavell, J., Kalk, E., Piper, K., Lee, S. P., Machado, L., Hadley, K., Sundblad, A., Sjoberg, J., Bjorkholm, M., Porwit, A., Yap, L-F., Teo, S., Grundy, R., Young, L. S., Ernberg, I. & 2 others, Woodman, C. & Murray, P., 1 Jul 2008, In : The American Journal of Pathology. 173, 1, p. 195-204

Research output: Contribution to JournalArticle

IGH@ translocations involving the pseudoautosomal region 1 (PAR1) of both sex chromosomes deregulate the cytokine receptor-like factor 2 (CRLF2) gene in B cell precursor acute lymphoblastic leukemia (BCP-ALL)

Russell, L., Capasso, M., Vater, I., Moorman, A., Akasaka, T., Harder, L., Heidenreich, O., Machado, L., Gest, S., Strefford, J., Chandrasekaran, T., Tonnies, H., Majid, A., Bernard, O., Dyer, M., Siebert, R. & Harrison, C., 1 Jan 2008.

Research output: Contribution to ConferenceAbstract

Selective accumulation of virus-specific CD8+ T cells with unique homing phenotype within the human bone marrow

Palendira, U., Chinn, R., Raza, W., Piper, K., Pratt, G., Machado, L., Bell, A., Khan, N., Hislop, A., Steyn, R., Rickinson, A., Buckley, C. & Moss, P., 15 Oct 2008, In : Blood. 112, 8

Research output: Contribution to JournalArticle

Open Access
2007

CXCR6 and CCR5 mediate recruitment of CD4 and CD8 T lymphocytes to nasopharyngeal carcinoma

Machado, L., Schmaler, T. T., Balasothy, M., Morgan, S., Larsen, M., Hislop, A., Murray, P., Mack, M., Adams, D., Van Hasselt, A., Hui, E. P., Chan, A. T. C. & Lee, S. P., 1 Jan 2007.

Research output: Contribution to ConferenceAbstract

Molecular mechanisms for T cell recruitment to Hodgkin's lymphoma

Machado, L., Jarrett, R., Morgan, S., Murray, P., Hunter, B., Crocker, J., Thomas, W., Steven, N., Ismail, T., Chapman, A., Adams, D. & Lee, S. P., 1 Mar 2007.

Research output: Contribution to ConferenceAbstract

2006

Biomarkers of the immune response in primary colorectal cancer

Hamilton, E., Machado, L., Reynolds, G. M., Taniere, P., Lee, S. P., Steven, N. & Ismail, T., 1 Jan 2006.

Research output: Contribution to ConferenceAbstract

2005

Infusing advanced cancer patients with tumour antigen-specific CD4+ and CD8+ T cell clones

Lee, S. P., Green, A. M., Machado, L., Patel, P., Thomas, W., Goodyear, O., Briggs, D., McDonald, D., Marsden, J. & Steven, N., 1 Jan 2005.

Research output: Contribution to ConferenceAbstract

2003

Generating cancer/testis antigen- and Epstein-Barr virus-specific T cell clones for adoptive immunotherapy

Lee, S. P., Hewitt, A., Thomas, W., Machado, L., Goodyear, O., Marsden, J., Van der, B., Briggs, D. & Steven, N., 1 Jan 2003.

Research output: Contribution to ConferenceAbstract