Projects per year
Personal profile
Research Interests
Mosavar specializes in studying exosomal microRNA in haematological malignancies. Her research revolves around understanding the roles of microRNAs in cancer, with a particular focus on their potential as non-invasive prognostic biomarkers. One of her published works explores the impact of miR-202 found in exosomes isolated from plasma on the transcriptome and behaviour of recipient cells in chronic lymphocytic leukaemia.
In addition to her work on chronic lymphocytic leukaemia, Mosavar is actively investigating the prognostic role of microRNAs in Multiple Myeloma. This research is conducted in collaboration with the Northwest Anglia NHS Foundation Trust at Peterborough City Hospital, enhancing the clinical applicability of her findings.
Mosavar is also engaged in collaborative research with Professor Lugan Yu, an expert in Glyco-oncology in University of Liverpool. Together, they are exploring the potential of Plasma Galectin-3 as a prognostic biomarker in Multiple Myeloma, considering its involvement in signalling pathways.
Beyond haematological malignancies, Mosavar extends her research interests to the potential of exosomes microRNAs as drug delivery vehicles in neurological diseases. This interdisciplinary approach reflects Mosavar commitment to advancing knowledge in both haematological malignancies and neurological diseases, bridging the gap between cancer research and neurology.
Overall, Mosavar's research spans various aspects of exosomal microRNAs, from their specific roles in chronic lymphocytic leukaemia to their potential as prognostic biomarkers in multiple myeloma. The collaborations with clinical institutions and experts in related fields strengthen the translational and interdisciplinary nature of her research. This work may contribute not only to advancing our understanding of haematological malignancies but also to the development of clinically relevant diagnostic and prognostic tools.
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Projects
- 1 Active
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Investigate the value of plasma galectin-3 and RANKL measurements in predicting disease progression and skeletal complications in Multiple Myeloma
Farahani, M., Machado, L., SIVAKUMARAN, M. & Yu, L.
2/10/23 → 2/10/24
Project: Research › Charitable Funding
Research output
- 6 Article
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A novel panel of differentially-expressed microRNAs in breast cancer brain metastasis may predict patient survival.
Giannoudis, A., Clarke, K., Zakaria, R., Vareslija, D., Farahani, M., Rainbow, L., Platt-Higgins, A., Ruthven, S., Brougham, KA., Rudland, PS., Jenkinson, MD., Young, LS., Falciani, F. & Palmieri, C., 6 Dec 2019, In: Scientific Reports. 18518.Research output: Contribution to Journal › Article › peer-review
Open Access -
CLL Exosomes Modulate the Transcriptome and Behaviour of Recipient Stromal Cells and Are Selectively Enriched in miR-202-3p.
Farahani, M., Rubbi, C., Liu, L-N., Slupsky, J. & Kalakonda, N., 28 Oct 2015, In: PLoS ONE.Research output: Contribution to Journal › Article › peer-review
Open AccessFile -
Loss of MIR15A and MIR16-1 at 13q14 is associated with increased TP53 mRNA, de-repression of BCL2 and adverse outcome in chronic lymphocytic leukaemia.
Lin, K., Farahani, M., Yang, Y., Johnson, GG., Oates, M., Atherton, M., Douglas, A., Kalakonda, N. & Pettitt, AR., 18 Jul 2014, In: British Journal of Haematology. p. 346-355 9 p., 167.Research output: Contribution to Journal › Article › peer-review
Open AccessFile -
B-cell receptor signaling in chronic lymphocytic leukemia cells is regulated by overexpressed active protein kinase CbetaII.
Abrams, S., Lakum, T., Lin, K., Jones, GM., Treweeke, AT., Farahani, M., Hughes, M., Zuzel, M. & Slupsky, J., 26 Sept 2006, In: Blood.Research output: Contribution to Journal › Article › peer-review
Open AccessFile -
Autocrine VEGF mediates the antiapoptotic effect of CD154 on CLL cells.
Farahani, M., Treweeke, AT., Toh, CH., Till, K., Harris, RJ., Cawley, JC., Zuzel, M. & Chen, H., 1 Apr 2005, In: Leukemia.Research output: Contribution to Journal › Article › peer-review
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Molecular analysis of paired tumours: time to start treating the field.
Pateromichelakis, S., Farahani, M., Phillips, E. & Partridge, M., 1 Oct 2005, In: Oral Oncology. 41, 9Research output: Contribution to Journal › Article › peer-review
Activities
- 2 Membership of council
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British Society for Haematology (External organisation)
Mosavar Farahani (Member)
2021Activity: Membership of a Board, Committee, Council or Network › Membership of council › Research
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Institute of Biomedical Science (IBMS) (External organisation)
Mosavar Farahani (Member)
2021Activity: Membership of a Board, Committee, Council or Network › Membership of council › Research