Personal profile
Biography
Rob began his career studying Biological Sciences at the University of Leicester and graduated in 1998. He then stayed at Leicester and received an MRes and PhD, followed by work as a Research Associate for Professor Flaviano Giorgini between 2006 and 2022. His postdoctoral work involved identifying and characterising genetic modifiers of neurodegenerative disease to discover novel therapeutic strategies. He has also worked as a Teaching Fellow and a Scientific Officer in the genomics core facility at Leicester. Rob started as an Associate Lecturer at the University of Northampton in 2022 and became a Senior Lecturer in Molecular Medicine in 2023. He is also a member of the Centre for Physical Activity and Life Sciences.
Research Interests
Rob's research focuses on identifying genes that influence the onset and symptomatic profile of neurodegenerative diseases. His main interests lie in understanding how they cause disease, and using this information to uncover novel therapeutic strategies.
Key areas of interest include:
- Using model organisms to understand neurodegenerative disease
- Identifying common factors in neurodegenerative disease
- Developing novel therapeutic strategies for Huntington's disease
- Rab GTPase function and dysfunction in neurodegeneration
Teaching Interests
Rob primarily contributes to teaching on the MSc Molecular medicine, and is module lead for:
- SLSM014 Genetics and Genomics
- SLSM011 Research Methods: Quantitative Statistical Analyses
- SPOM019 Applied Practice
Education/Academic qualification
PhD, Identification and Analysis of Ferric Reductase Genes in Candida albicans, University of Leicester
1 Sept 2000 → 1 Mar 2006
Award Date: 1 Mar 2006
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Master, Study of Ligand-Binding Sites in Talin and Vinculin, University of Leicester
1 Sept 1998 → 1 Sept 1999
Award Date: 1 Sept 1999
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Bachelor, Biological Sciences, University of Leicester
1 Sept 1995 → 1 Jul 1998
Award Date: 1 Jul 1998
External positions
Honorary Visiting Fellow, University of Leicester
29 Sept 2022 → 28 Sept 2023
Fingerprint
- 1 Similar Profiles
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Kynurenine 3-Monooxygenase Interacts with Huntingtin at the Outer Mitochondrial Membrane.
Swaih, A. M., Breda, C., Sathyasaikumar, K. V., Allcock, N., Collier, M. E. W., Mason, R. P., Feasby, A., Herrera, F., Outeiro, T. F., Schwarcz, R., Repici, M. & Giorgini, F., 15 Sept 2022, In: Biomedicines. 10, 9, 17 p., 2294.Research output: Contribution to Journal › Article › peer-review
Open Access -
Connectivity mapping uncovers small molecules that modulate neurodegeneration in Huntington's disease models
Smalley, J., Breda, C., Mason, R., Kooner, G., Luthi-Carter, R., Gant, T. & Giorgini, F., 2 Oct 2015, In: Journal of molecular medicine (Berlin, Germany). 94, p. 235-245Research output: Contribution to Journal › Article › peer-review
Open Access -
Aggregation-prone proteins modulate huntingtin inclusion body formation in yeast.
Kantcheva, R., Mason, R. & Giorgini, F., 23 Apr 2014, In: PLoS Currents.Research output: Contribution to Journal › Article › peer-review
Open Access -
Modeling Huntington Disease in Yeast and Invertebrates
Mason, R. P., Breda, C., Kooner, G. S., Mallucci, G. R., Kyriacou, C. P. & Giorgini, F., 12 Dec 2014, Movement Disorders. LeDoux, M. (ed.). Academic Press, p. 557-572Research output: Contribution to Book/Report › Chapter
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Glutathione peroxidase activity is neuroprotective in models of Huntington's disease.
Mason, R., Casu, M., Butler, N., Breda, C., Campesan, S., Clapp, J., Green, E., Dhulkhed, D., Kyriacou, C. & Giorgini, F., 25 Aug 2013, In: Nature Genetics. p. 1249-1254 13 p., 45.Research output: Contribution to Journal › Article › peer-review
Open Access -
Ferric reductase genes involved in high-affinity iron uptake are differentially regulated in yeast and hyphae of Candida albicans
Jeeves, R. E., Woodacre, A., Cashmore, A. M. & Mason, R., 21 Jun 2011, (E-pub ahead of print) In: Yeast. 28, 9, p. 629-644 16 p.Research output: Contribution to Journal › Article › peer-review
Open Access -
Functional gene expression profiling in yeast implicates translational dysfunction in mutant huntingtin toxicity.
Tauber, E., Miller-Fleming, L., Mason, R., Kwan, W., Clapp, J., Butler, N., Outeiro, T. F., Muchowski, P. & Giorgini, F., 7 Jan 2011, In: The Journal of Biological Chemistry. 286, 1, p. 410 419 p., 1.Research output: Contribution to Journal › Article › peer-review
Open Access -
Modeling Huntington disease in yeast: perspectives and future directions.
Mason, R. & Giorgini, F., 1 Oct 2011, In: Prion. 5, 4, p. 269-276 7 p.Research output: Contribution to Journal › Article › peer-review
Open Access