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  • Lee Machado
2018

High fat diet induced obesity modulates melanoma tumour microenvironment in low density lipoprotein receptor deficient LDLR-/- mouse model.

Al-Zubaidi, R., Stover, C. & Machado, L. R., 13 Sep 2018, p. 90. 1 p.

Research output: Contribution to ConferenceAbstract

Open Access
Open Access
File

Targeting gp100 and TRP-2 with a DNA vaccine: incorporating T cell epitopes with a human IgG1 antibody induces potent T cell responses that are associated with favourable clinical outcome in a phase I/II trial

Patel, P. M., Ottensmeier, C., Mulatero, C., Lorigan, P., Plummer, R., Pandha, H., Elsheik, S., Hadjimichael, E., Villasanti, N., Adams, S. E., Cunnell, M., Metheringham, R. L., Brentville, V. A., Machado, L., Daniels, I., Gijon, M., Hannaman, D. & Durrant, L. G., 2018, In : OncoImmunology. 7, 6, p. e1433516

Research output: Contribution to JournalArticle

Open Access
File
2017

Abstract 9035: An adjuvant clinical trial of SCIB1, a DNA vaccine that targets dendritic cells in vivo, in fully resected melanoma patients

Patel, P. M., Ottensmeier, C., Mulatero, C., Lorigan, P., Plummer, R., Hannaman, D., Cunnell, M., Metheringham, R. L., Brentville, V. A., Daniels, I., Machado, L. & Durrant, L. G., 31 Jan 2017.

Research output: Contribution to ConferenceAbstract

Health and wellbeing amongst older people research in Northamptonshire

Poole, H., Sixsmith, J., Parkes, J., Ward, A., Pyer, M., Campbell, J., Machado, L., Rehling, T., Youell, J., Carter, J., Oyebode, J., O’Malley, M., Anthony, K., Rogers, S., Jones, J., Siddons, L., Smith, L-A., Kay, A. D., Fraser, M., Score, J. & 8 others, El Khoury, L., Hameed, A., Albalbeisi, N., Durrant, L. G., Al-Zubaidi, R., Al-Rayahi, I., da Silva, K. & Taylor, J., 1 Aug 2017, (East Midlands Research into Ageing Network (EMRAN) Discussion Paper Series).

Research output: Working PaperDiscussion Paper

Open Access
File

High mobility group protein B1 is a predictor of poor survival in ovarian cancer

Machado, L., Moseley, P. M., Moss, R., Deen, S., Nolan, C., Spendlove, I. & Ramage, J., 24 Nov 2017, In : Oncotarget. 8, 60

Research output: Contribution to JournalArticle

Open Access
File

Population genetics of immune-related multilocus copy number variation in Native Americans

Zuccherato, L., Schneider, S., Tarazona-Santos, E., Hardwick, R. J., Berg, D., Bogle, H., Gouveia, M., Machado, L., Machado, M., Rodrigues-Soares, F., Soares-Souza, G., Togni, D., Zamudio, R., Gilman, R., Duarte, D., Hollox, E. J. & Rodrigues, M. R., 29 Mar 2017, In : Journal of the Royal Society Interface. 14, 128

Research output: Contribution to JournalArticle

Open Access
File
2016

Downregulation of the citrullinating enzyme Peptidyl-arginine deiminase type-2 in ovarian cancer indicates poor prognosis

Machado, L., Moseley, P. M., Moss, R., Deen, S., Nolan, C., Spendlove, I., Ramage, J., Chan, S. & Durrant, L. G., 6 Nov 2016.

Research output: Contribution to ConferencePoster

File

Understanding the genomic structure of copy number variants of the low-affinity Fcγ receptor region allows confirmation of the association of FCGR3B deletion with rheumatoid arthritis

Rahbari, R., Zuccherato, L., Tischler, G., Chihota, B., Tarazona-Santos, E., Machado, L. & Hollox, E. J., 6 Dec 2016.

Research output: Contribution to ConferenceAbstract

Understanding the genomic structure of copy number variants of the low-affinity Fcγ receptor region allows confirmation of the association of FCGR3B deletion with rheumatoid arthritis

Rahbari, R., Zuccherato, L. W., Tischler, G., Chihota, B., Ozturk, H., Saleem, S., Tarazona-Santos, E., Machado, L. & Hollox, E. J., 20 Dec 2016, In : Human Mutation.

Research output: Contribution to JournalArticle

Open Access
File
2015

A clinical trial of a DNA vaccine (SCIB1) that targets dendritic cells in vivo in fully resected melanoma patients; a vaccine to prevent disease recurrence?

Durrant, L. G., Ottensmeier, C. H., Mulatero, C., Lorigan, P., Plummer, R., Cunnell, M., Metheringham, R., Brentville, V., Machado, L., Daniels, I., Hannaman, D. & Patel, P. M., 6 Oct 2015.

Research output: Contribution to ConferenceAbstract

Open Access
File
Open Access
File

Evaluation of high-throughput genomic assays for the Fc gamma receptor locus

Hargreaves, C. E., Iriyama, C., Rose-Zerilli, M. J. J., Nagelkerke, S. Q., Hussain, K., Ganderton, R., Lee, C., Machado, L., Hollox, E. J., Parker, H., Latham, K. V., Kuijpers, T. W., Potter, K. N., Coupland, S. E., Davies, A., Stackpole, M., Oates, M., Pettitt, A. R., Glennie, M. J., Cragg, M. S. & 1 others, Strefford, J. C., 6 Nov 2015, In : PLoS ONE. 10, 11

Research output: Contribution to JournalArticle

Open Access

Fcγ receptors: genetic variation, function, and disease

Hargreaves, C. E., Rose-Zerilli, M. J. J., Machado, L., Iriyama, C., Hollox, E. J., Cragg, M. S. & Strefford, J. C., 26 Oct 2015, In : Immunological Reviews. 268, 1, p. 1-19 19 p.

Research output: Contribution to JournalArticle

Human Leukocyte Antigen (HLA) A*1101-restricted Epstein-Barr virus-specific T-cell receptor gene transfer to target Nasopharyngeal carcinoma

Zheng, Y., Parsonage, G., Zhuang, X., Machado, L., James, C., Salman, A., Searle, P., Hui, E. P., Chan, A. T. C. & Lee, S. P., 1 Oct 2015, In : Cancer Immunology Research. 3, 10

Research output: Contribution to JournalArticle

Open Access
File
2014

Abstract CT331: Phase I/II trial of a novel antibody DNA immunotherapy, targeting CD64, in the treatment of Melanoma

Durrant, L. G., Ottensmeier, C., Lorigan, P., Mulatero, C., Plummer, R., Cunell, M., Metheringham, R. L., Brentville, V. A. & Machado, L., 1 Oct 2014.

Research output: Contribution to ConferenceAbstract

DNA vaccines

Durrant, L. G., Xue, L., Machado, L., Metheringham, R. L., Brentville, V. A. & Rees, R. C. (ed.), 29 May 2014, Tumor Immunology and Immunotherapy. Oxford: Oxford University Press, p. 251-264 14 p.

Research output: Contribution to Book/ReportChapter

Genomic dissection of the Fcγ receptor region in the context of monoclonal antibody therapy

Hargreaves, C., Iriyama, C., Rose-Zerilli, M., Lee, C., Potter, K., Ganderton, R., Hussain, K., Machado, L., Hollox, E. J., Coupland, S., Stackpole, M., Oates, M., Pettitt, A. R., Cragg, M. & Strefford, J., 6 Dec 2014.

Research output: Contribution to ConferenceAbstract

High-mobility group protein 1 (HMGB1) is an independent predictor of poor survival in ovarian cancer

Machado, L., Moseley, P., Moss, R., Nolan, C., Rampage, J., Chan, S. & Durrant, L. G., 1 Jan 2014.

Research output: Contribution to ConferenceAbstract

Phase I trial of ImmunoBody in melanoma patients

Patel, P. M., Durrant, L. G., Ottensmeier, C., Mulatero, C., Lorigan, P., Plummer, R., Cunnell, M., Metheringham, R. L., Brentville, V. A., Machado, L., Daniels, I. & Hannaman, D., 1 Jun 2014.

Research output: Contribution to ConferenceAbstract

Septicaemia models using Streptococcus pneumoniae and Listeria monocytogenes: understanding the role of complement properdin

Dupont, A., Mohamed, F., Salehen, NA., Glenn, S., Francescut, L., Adib, R., Byrne, S., Brewin, H., Elliott, I., Richards, L., Dimitrova, P., Schwaeble, W., Ivanovska, N., Kadioglu, A., Machado, L., Andrew, P. W. & Stover, C., 1 Aug 2014, In : Medical Microbiology and Immunology. 203, 4, p. 257–271 15 p.

Research output: Contribution to JournalArticle

Open Access
File
2013

Copy number variation of Fc gamma receptor genes in HIV-infected and HIV-tuberculosis co-infected individuals in Sub-Saharan Africa

Machado, L., Bowdrey, J., Ngaimisi, E., Habtewold, A., Minzi, O., Makonnen, E., Yimer, G., Amogne, W., Mugusi, S., Janabi, M., Aderaye, G., Mugusi, F., Viskaduraki, M., Aklillu, E. & Hollox, E. J., 1 Nov 2013, In : PLoS ONE. 8, 11

Research output: Contribution to JournalArticle

Open Access
File
2012

B-defensin genomic copy number is associated with HIV load and immune reconstitution in sub-Saharan Africans

Hardwick, R. J., Amogne, W., Mugusi, S., Yimer, G., Ngaimisi, E., Habtewold, A., Minzi, O., Makonnen, E., Janabi, M., Machado, L., Viskaduraki, M., Mugusi, F., Aderaye, G., Lindquist, L., Hollox, E. J. & Aklillu, E., 1 Oct 2012, In : The Journal of Infectious Diseases. 206, 7

Research output: Contribution to JournalArticle

Open Access

CXCR6 and CCR5 localize T lymphocyte subsets in nasopharyngeal carcinoma

Parsonage, G., Machado, L., Hui, J. W-Y., McLarnon, A., Schmaler, T., Balasothy, M., To, K-F., Vlantis, A. C., Hasselt, C. A. V., Lo, K-W., Wong, W-L., Hui, E. P., Cheung Chan, A. T. & Lee, S. P., 3 Mar 2012, In : American Journal of Pathology. 180, 3, p. 1215-1222 7 p.

Research output: Contribution to JournalArticle

Open Access

Evolutionary history of copy-number-variable locus for the low-affinity Fcy receptor: mutation rate, autoimmune disease, and the legacy of helminth infection

Machado, L., Hardwick, R. J., Bowdrey, J., Bogle, H., Knowles, T., Sironi, M. & Hollox, E. J., 8 Jun 2012, In : The American Journal of Human Genetics. 90, 6, p. 973-985 12 p.

Research output: Contribution to JournalArticle

Open Access
File
2011

A worldwide analysis of beta-defensin copy number variation suggests recent selection of a high-expressing DEFB103 gene copy in East Asia

Hardwick, R. J., Machado, L., Zuccherato, L., Antolinos, S., Xue, Y., Shawa, N., Gilman, R., Cabrera, L., Berg, D., Tyler-Smith, C., Kelly, P., Tarazona-Santos, E. & Hollox, E. J., 1 Jul 2011, In : Human Mutation. 32, 7

Research output: Contribution to JournalArticle

β-Defensin genomic copy number is associated with HIV viral load and immune reconstitution in sub-Saharan Africans

Hardwick, R. J., Amogne, W., Mugusi, S., Yimer, G., Ngaimisi, E., Habtewold, A., Minzi, O., Makonnen, E., Janabi, M., Machado, L., Mugusi, F., Aderaye, G., Lindquist, L., Hollox, E. J. & Aklillu, E., 1 Dec 2011.

Research output: Contribution to ConferenceAbstract