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2018

High fat diet induced obesity modulates melanoma tumour microenvironment in low density lipoprotein receptor deficient LDLR-/- mouse model.

Al-Zubaidi, R., Stover, C. & Machado, L. R., 13 Sep 2018, p. 90. 1 p.

Research output: Contribution to ConferenceAbstract

Open Access
Tumor Microenvironment
LDL Receptors
High Fat Diet
Melanoma
Obesity
Open Access
File
Dystrophin
Duchenne Muscular Dystrophy
Cell Movement
Protein Isoforms
Cell Proliferation

Targeting gp100 and TRP-2 with a DNA vaccine: incorporating T cell epitopes with a human IgG1 antibody induces potent T cell responses that are associated with favourable clinical outcome in a phase I/II trial

Patel, P. M., Ottensmeier, C., Mulatero, C., Lorigan, P., Plummer, R., Pandha, H., Elsheik, S., Hadjimichael, E., Villasanti, N., Adams, S. E., Cunnell, M., Metheringham, R. L., Brentville, V. A., Machado, L., Daniels, I., Gijon, M., Hannaman, D. & Durrant, L. G., 2018, In : OncoImmunology. 7, 6, p. e1433516

Research output: Contribution to JournalArticle

Open Access
File
DNA Vaccines
T-Lymphocyte Epitopes
Immunoglobulin G
T-Lymphocytes
Antibodies
2017

Abstract 9035: An adjuvant clinical trial of SCIB1, a DNA vaccine that targets dendritic cells in vivo, in fully resected melanoma patients

Patel, P. M., Ottensmeier, C., Mulatero, C., Lorigan, P., Plummer, R., Hannaman, D., Cunnell, M., Metheringham, R. L., Brentville, V. A., Daniels, I., Machado, L. & Durrant, L. G., 31 Jan 2017.

Research output: Contribution to ConferenceAbstract

DNA Vaccines
Dendritic Cells
Melanoma
Clinical Trials
Epitopes

Health and wellbeing amongst older people research in Northamptonshire

Poole, H., Sixsmith, J., Parkes, J., Ward, A., Pyer, M., Campbell, J., Machado, L., Rehling, T., Youell, J., Carter, J., Oyebode, J., O’Malley, M., Anthony, K., Rogers, S., Jones, J., Siddons, L., Smith, L-A., Kay, T., Fraser, M., Score, J. & 8 others, El Khoury, L., Hameed, A., Albalbeisi, N., Durrant, L. G., Al-Zubaidi, R., Al-Rayahi, I., da Silva, K. & Taylor, J., 1 Aug 2017, In : East Midlands Research into Ageing Network (EMRAN) Discussion Paper Series. 15

Research output: Contribution to JournalArticle

Open Access
File
health
research practice
commitment
Values

High mobility group protein B1 is a predictor of poor survival in ovarian cancer

Machado, L., Moseley, P. M., Moss, R., Deen, S., Nolan, C., Spendlove, I. & Ramage, J., 24 Nov 2017, In : Oncotarget. 8, 60

Research output: Contribution to JournalArticle

Open Access
File
High Mobility Group Proteins
Ovarian Neoplasms
Survival
Neoplasms
Kaplan-Meier Estimate

Population genetics of immune-related multilocus CNV in Native Americans

Zuccherato, L., Schneider, S., Tarazona-Santos, E., Hardwick, R. J., Berg, D., Bogle, H., Gouveia, M., Machado, L., Machado, M., Rodrigues-Soares, F., Soares-Souza, G., Togni, D., Zamudio, R., Gilman, R., Duarte, D., Hollox, E. J. & Rodrigues, M. R., 29 Mar 2017, In : Journal of the Royal Society Interface. 14, 128

Research output: Contribution to JournalArticle

Open Access
File
American Indians
population genetics
loci
population structure
assortative mating
2016

Downregulation of the citrullinating enzyme Peptidyl-arginine deiminase type-2 in ovarian cancer indicates poor prognosis

Machado, L., Moseley, P. M., Moss, R., Deen, S., Nolan, C., Spendlove, I., Ramage, J., Chan, S. & Durrant, L. G., 6 Nov 2016.

Research output: Contribution to ConferencePoster

File
Ovarian Neoplasms
Down-Regulation
Enzymes
HMGB1 Protein
Neoplasms

Understanding the genomic structure of copy number variants of the low-affinity Fcγ receptor region allows confirmation of the association of FCGR3B deletion with rheumatoid arthritis

Rahbari, R., Zuccherato, L., Tischler, G., Chihota, B., Tarazona-Santos, E., Machado, L. & Hollox, E. J., 6 Dec 2016.

Research output: Contribution to ConferenceAbstract

Fc Receptors
Rheumatoid Arthritis
Alleles
Genomic Segmental Duplications
Immunoglobulin Fc Fragments

Understanding the genomic structure of copy number variants of the low-affinity Fcγ receptor region allows confirmation of the association of FCGR3B deletion with rheumatoid arthritis

Rahbari, R., Zuccherato, L. W., Tischler, G., Chihota, B., Ozturk, H., Saleem, S., Tarazona-Santos, E., Machado, L. & Hollox, E. J., 20 Dec 2016, In : Human Mutation.

Research output: Contribution to JournalArticle

Open Access
File
Fc Receptors
Rheumatoid Arthritis
Alleles
Genomic Segmental Duplications
Immunoglobulin Fc Fragments
2015

A clinical trial of a DNA vaccine (SCIB1) that targets dendritic cells in vivo in fully resected melanoma patients; a vaccine to prevent disease recurrence?

Durrant, L. G., Ottensmeier, C. H., Mulatero, C., Lorigan, P., Plummer, R., Cunnell, M., Metheringham, R., Brentville, V., Machado, L., Daniels, I., Hannaman, D. & Patel, P. M., 6 Oct 2015.

Research output: Contribution to ConferenceAbstract

Open Access
File
DNA Vaccines
Dendritic Cells
Melanoma
Vaccines
Clinical Trials

A comparison of assays for accurate copy number measurement of the low-affinity Fc gamma receptor genes FCGR3A and FCGR3B

Haridan, U. S., Mokhtar, U., Machado, L., Abdul Aziz, A. T., Shueb, R. H., Zaid, M., Sim, B., Mustafa, M., Nik Yusof, N. K., Lee, C. K. C., Abu Bakar, S., AbuBakar, S., Hollox, E. J. & Boon Peng, H., 16 Jan 2015, In : PLoS ONE. 10, 1

Research output: Contribution to JournalArticle

IgG Receptors
Genetic Association Studies
Genes
Gene Dosage
Cellular Immunity
Open Access
File
Defensins
Adaptive Immunity
Innate Immunity
Peptides
Psoriasis

Evaluation of high-throughput genomic assays for the Fc gamma receptor locus

Hargreaves, C. E., Iriyama, C., Rose-Zerilli, M. J. J., Nagelkerke, S. Q., Hussain, K., Ganderton, R., Lee, C., Machado, L., Hollox, E. J., Parker, H., Latham, K. V., Kuijpers, T. W., Potter, K. N., Coupland, S. E., Davies, A., Stackpole, M., Oates, M., Pettitt, A. R., Glennie, M. J., Cragg, M. S. & 1 others, Strefford, J. C., 6 Nov 2015, In : PLoS ONE. 10, 11

Research output: Contribution to JournalArticle

Open Access
IgG Receptors
Single Nucleotide Polymorphism
Multiplex Polymerase Chain Reaction
Paraffin
Formaldehyde

Fcγ receptors: genetic variation, function, and disease

Hargreaves, C. E., Rose-Zerilli, M. J. J., Machado, L., Iriyama, C., Hollox, E. J., Cragg, M. S. & Strefford, J. C., 26 Oct 2015, In : Immunological Reviews. 268, 1, p. 1-19 19 p.

Research output: Contribution to JournalArticle

Inborn Genetic Diseases
Fc Receptors
Autoimmunity
Humoral Immunity
Infection

Human Leukocyte Antigen (HLA) A*1101-restricted Epstein-Barr virus-specific T-cell receptor gene transfer to target Nasopharyngeal carcinoma

Zheng, Y., Parsonage, G., Zhuang, X., Machado, L., James, C., Salman, A., Searle, P., Hui, E. P., Chan, A. T. C. & Lee, S. P., 1 Oct 2015, In : Cancer Immunology Research. 3, 10

Research output: Contribution to JournalArticle

Open Access
File
T-Cell Receptor Genes
HLA Antigens
Human Herpesvirus 4
T-Lymphocytes
T-Cell Antigen Receptor