A functional variant within the MMP3 gene does not associate with human range of motion

Michael Posthumus, Stuart M Raleigh, William J Ribbans, M P Schwellnus, M Collins

Research output: Contribution to journalArticleResearchpeer-review

Abstract

A recent heritability study has demonstrated that human range of motion (ROM) has a substantial genetic component. Furthermore, the COL5A1BstUI RFLP has now been identified as the first gene variant to be associated with human ROM. Interestingly, this variant is known to interact with a functional variant within the MMP3 gene (rs679620) to increase risk of Achilles tendinopathy. We sought to determine whether the MMP3 rs679620 variant was associated with ROM both as a single marker and as an interacting marker with the COL5A1 BstUI RFLP. One hundred and twenty one participants were included in this study. All participants were genotyped for the MMP3 rs679620 variant, and performed passive straight leg raise (SLR) and sit and reach (SR) measurements. There were no significant differences in left leg SLR (L-SLR), right leg SLR (R-SLR), or SR measurements between the genotype groups (L-SLR, P=0.494; R-SLR, P=0.435; SR, P=0.266). Furthermore, there was no evidence of an interaction between the COL5A1 BstUI RFLP and the MMP3 rs679620 variant. Our study suggests that the MMP3 rs679620 variant does not associate with passive ROM.
Original languageEnglish
Pages (from-to)630-632
Number of pages2
JournalJournal of Science and Medicine in Sport
Volume13
Issue number6
Early online date1 Apr 2010
DOIs
Publication statusPublished - 1 Nov 2010

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Articular Range of Motion
Leg
Genes
Restriction Fragment Length Polymorphisms
Tendinopathy
Genotype

Cite this

Posthumus, Michael ; Raleigh, Stuart M ; Ribbans, William J ; Schwellnus, M P ; Collins, M. / A functional variant within the MMP3 gene does not associate with human range of motion. In: Journal of Science and Medicine in Sport. 2010 ; Vol. 13, No. 6. pp. 630-632.
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abstract = "A recent heritability study has demonstrated that human range of motion (ROM) has a substantial genetic component. Furthermore, the COL5A1BstUI RFLP has now been identified as the first gene variant to be associated with human ROM. Interestingly, this variant is known to interact with a functional variant within the MMP3 gene (rs679620) to increase risk of Achilles tendinopathy. We sought to determine whether the MMP3 rs679620 variant was associated with ROM both as a single marker and as an interacting marker with the COL5A1 BstUI RFLP. One hundred and twenty one participants were included in this study. All participants were genotyped for the MMP3 rs679620 variant, and performed passive straight leg raise (SLR) and sit and reach (SR) measurements. There were no significant differences in left leg SLR (L-SLR), right leg SLR (R-SLR), or SR measurements between the genotype groups (L-SLR, P=0.494; R-SLR, P=0.435; SR, P=0.266). Furthermore, there was no evidence of an interaction between the COL5A1 BstUI RFLP and the MMP3 rs679620 variant. Our study suggests that the MMP3 rs679620 variant does not associate with passive ROM.",
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A functional variant within the MMP3 gene does not associate with human range of motion. / Posthumus, Michael; Raleigh, Stuart M; Ribbans, William J; Schwellnus, M P; Collins, M.

In: Journal of Science and Medicine in Sport, Vol. 13, No. 6, 01.11.2010, p. 630-632.

Research output: Contribution to journalArticleResearchpeer-review

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