A yeast artificial chromosome-based physical map of the juvenile amyotrophic lateral sclerosis (ALS2) critical region on human chromosome 2q33-q34

Shinji Hadano, Kerrie Nichol, Ryan R. Brinkman, Jamal Nasir, Duane Martindale, Ben F. Koop, Donald W. Nicholson, Stephen W. Scherer, Joh E. Ikeda, Michael R. Hayden

    Research output: Contribution to JournalArticlepeer-review

    Abstract

    The autosomal recessive form of juvenile amyotrophic lateral sclerosis (ALS2; RFALS Type 3) has previously been mapped to the 8-cM interval flanked by D2S115 and D2S155 on human chromosome 2q33-q34. We have established a yeast artificial chromosome (YAC) contig spanning an approximately 8-Mb region of the ALS2 candidate region and mapped 52 transcribed DNA sequences including 13 known genes and 39 expressed sequenced tags within this YAC contig. The establishment of a YAC contig and transcript map that spans the region containing the ALS2 mutation is an essential step in the identification of the ALS2 gene.
    Original languageEnglish
    Pages (from-to)106-112
    Number of pages7
    JournalBMC Genomics
    Volume55
    Issue number1
    DOIs
    Publication statusPublished - 1 Jan 1999

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