A yeast artificial chromosome-based physical map of the juvenile amyotrophic lateral sclerosis (ALS2) critical region on human chromosome 2q33-q34

Shinji Hadano; Kerrie Nichol; Ryan R. Brinkman; Jamal Nasir; Duane Martindale; Ben F. Koop; Donald W. Nicholson; Stephen W. Scherer; Joh E. Ikeda; Michael R. Hayden

doi:10.1006/geno.1998.5637

A yeast artificial chromosome-based physical map of the juvenile amyotrophic lateral sclerosis (ALS2) critical region on human chromosome 2q33-q34

Shinji Hadano, Kerrie Nichol, Ryan R. Brinkman, Jamal Nasir, Duane Martindale, Ben F. Koop, Donald W. Nicholson, Stephen W. Scherer, Joh E. Ikeda, Michael R. Hayden

Research output: Contribution to Journal › Article › peer-review

Abstract

The autosomal recessive form of juvenile amyotrophic lateral sclerosis (ALS2; RFALS Type 3) has previously been mapped to the 8-cM interval flanked by D2S115 and D2S155 on human chromosome 2q33-q34. We have established a yeast artificial chromosome (YAC) contig spanning an approximately 8-Mb region of the ALS2 candidate region and mapped 52 transcribed DNA sequences including 13 known genes and 39 expressed sequenced tags within this YAC contig. The establishment of a YAC contig and transcript map that spans the region containing the ALS2 mutation is an essential step in the identification of the ALS2 gene.

Original language	English
Pages (from-to)	106-112
Number of pages	7
Journal	BMC Genomics
Volume	55
Issue number	1
DOIs	https://doi.org/10.1006/geno.1998.5637
Publication status	Published - 1 Jan 1999

Access to Document

10.1006/geno.1998.5637

Cite this

@article{854487dc893e4cefa760ef33d0333ee7,

title = "A yeast artificial chromosome-based physical map of the juvenile amyotrophic lateral sclerosis (ALS2) critical region on human chromosome 2q33-q34",

abstract = "The autosomal recessive form of juvenile amyotrophic lateral sclerosis (ALS2; RFALS Type 3) has previously been mapped to the 8-cM interval flanked by D2S115 and D2S155 on human chromosome 2q33-q34. We have established a yeast artificial chromosome (YAC) contig spanning an approximately 8-Mb region of the ALS2 candidate region and mapped 52 transcribed DNA sequences including 13 known genes and 39 expressed sequenced tags within this YAC contig. The establishment of a YAC contig and transcript map that spans the region containing the ALS2 mutation is an essential step in the identification of the ALS2 gene.",

author = "Shinji Hadano and Kerrie Nichol and Brinkman, {Ryan R.} and Jamal Nasir and Duane Martindale and Koop, {Ben F.} and Nicholson, {Donald W.} and Scherer, {Stephen W.} and Ikeda, {Joh E.} and Hayden, {Michael R.}",

year = "1999",

month = jan,

day = "1",

doi = "10.1006/geno.1998.5637",

language = "English",

volume = "55",

pages = "106--112",

journal = "BMC Genomics",

issn = "1471-2164",

publisher = "Springer Verlag",

number = "1",

}

TY - JOUR

T1 - A yeast artificial chromosome-based physical map of the juvenile amyotrophic lateral sclerosis (ALS2) critical region on human chromosome 2q33-q34

AU - Hadano, Shinji

AU - Nichol, Kerrie

AU - Brinkman, Ryan R.

AU - Nasir, Jamal

AU - Martindale, Duane

AU - Koop, Ben F.

AU - Nicholson, Donald W.

AU - Scherer, Stephen W.

AU - Ikeda, Joh E.

AU - Hayden, Michael R.

PY - 1999/1/1

Y1 - 1999/1/1

N2 - The autosomal recessive form of juvenile amyotrophic lateral sclerosis (ALS2; RFALS Type 3) has previously been mapped to the 8-cM interval flanked by D2S115 and D2S155 on human chromosome 2q33-q34. We have established a yeast artificial chromosome (YAC) contig spanning an approximately 8-Mb region of the ALS2 candidate region and mapped 52 transcribed DNA sequences including 13 known genes and 39 expressed sequenced tags within this YAC contig. The establishment of a YAC contig and transcript map that spans the region containing the ALS2 mutation is an essential step in the identification of the ALS2 gene.

AB - The autosomal recessive form of juvenile amyotrophic lateral sclerosis (ALS2; RFALS Type 3) has previously been mapped to the 8-cM interval flanked by D2S115 and D2S155 on human chromosome 2q33-q34. We have established a yeast artificial chromosome (YAC) contig spanning an approximately 8-Mb region of the ALS2 candidate region and mapped 52 transcribed DNA sequences including 13 known genes and 39 expressed sequenced tags within this YAC contig. The establishment of a YAC contig and transcript map that spans the region containing the ALS2 mutation is an essential step in the identification of the ALS2 gene.

UR - http://www.mendeley.com/research/yeast-artificial-chromosomebased-physical-map-juvenile-amyotrophic-lateral-sclerosis-als2-critical-r

U2 - 10.1006/geno.1998.5637

DO - 10.1006/geno.1998.5637

M3 - Article

C2 - 9889004

SN - 1471-2164

VL - 55

SP - 106

EP - 112

JO - BMC Genomics

JF - BMC Genomics

IS - 1

ER -

A yeast artificial chromosome-based physical map of the juvenile amyotrophic lateral sclerosis (ALS2) critical region on human chromosome 2q33-q34

Abstract

Access to Document

Other files and links

Fingerprint

Cite this