Construction of Lumped-parameter Cardiovascular Models Using the CellML Language

Yubing Shi, P.V. Lawford, D.R. Hose

Research output: Contribution to JournalArticlepeer-review


Lumped-parameter models are widely used by cardiovascular researchers in the analysis of the circulatory dynamics. However, portability and model exchange have always been a problem, with different researchers implement the model differently. To improve the situation, in this study, a group of lumped-parameter cardiovascular system models with different levels of complexity have been implemented using the CellML mark-up language. The models have been curated and made publicly available in the CellML model repository, and the purpose of this paper is to provide further technical details to support the usage of these models by the research community. The developed models are validated and tested under the OpenCell environment as part of the curation process. Simulation results agree well with typical published data on cardiovascular system response.
Original languageEnglish
Article number7
Pages (from-to)525-531
Number of pages7
JournalJournal of medical engineering & technology
Issue number7
Early online date18 Feb 2019
Publication statusE-pub ahead of print - 18 Feb 2019


  • Lumped-parameter model
  • Cardiovascular system
  • Numerical simulation
  • CellML


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