Cost-effectiveness of cryotherapy versus salicylic acid for the treatment of plantar warts: economic evaluation alongside a randomised controlled trial (EVerT trial)

Eugena Stamuli, Sarah Cockayne, Catherine Hewitt, Kate Hicks, Shalmini Jayakody, Arthur Ricky Kang'ombe, Gwen Turner, Kim Thomas, Mike Curran, Farina Hashmi, Caroline McIntosh, Nichola McLarnon, David J Torgerson, Ian Watt

Research output: Contribution to journalArticle

Abstract

BACKGROUND: Plantar warts (verrucae) are extremely common. Although many will spontaneously disappear without treatment, treatment may be sought for a variety of reasons such as discomfort. There are a number of different treatments for cutaneous warts, with salicylic acid and cryotherapy using liquid nitrogen being two of the most common forms of treatment. To date, no full economic evaluation of either salicylic acid or cryotherapy has been conducted based on the use of primary data in a pragmatic setting. This paper describes the cost-effectiveness analysis which was conducted alongside a pragmatic multicentre, randomised trial evaluating the clinical effectiveness of cryotherapy versus 50% salicylic acid of the treatment of plantar warts. METHODS: A cost-effectiveness analysis was undertaken alongside a pragmatic multicentre, randomised controlled trial assessing the clinical effectiveness of 50% salicylic acid and cryotherapy using liquid nitrogen at 12 weeks after randomisation of patients. Cost-effectiveness outcomes were expressed as the additional cost required to completely cure the plantar warts of one additional patient. A NHS perspective was taken for the analysis. RESULTS: Cryotherapy costs on average £101.17 (bias corrected and accelerated (BCA) 95% CI: 85.09-117.26) more per participant over the 12 week time-frame, while there is no additional benefit, in terms of proportion of patients healed compared with salicylic acid. CONCLUSIONS: Cryotherapy is more costly and no more effective than salicylic acid
Original languageEnglish
JournalJournal of Foot and Ankle Research
Volume5
Issue number1:4
DOIs
Publication statusPublished - 27 Feb 2012

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Warts
Cryotherapy
Salicylic Acid
Cost-Benefit Analysis
Randomized Controlled Trials
Nitrogen
Therapeutics
Costs and Cost Analysis
Random Allocation
Multicenter Studies
Skin

Keywords

  • Plantar warts
  • verrucae
  • Cost-effectiveness analysis
  • salicylic acid
  • cryotherapy using liquid nitrogen

Cite this

Stamuli, Eugena ; Cockayne, Sarah ; Hewitt, Catherine ; Hicks, Kate ; Jayakody, Shalmini ; Kang'ombe, Arthur Ricky ; Turner, Gwen ; Thomas, Kim ; Curran, Mike ; Hashmi, Farina ; McIntosh, Caroline ; McLarnon, Nichola ; Torgerson, David J ; Watt, Ian. / Cost-effectiveness of cryotherapy versus salicylic acid for the treatment of plantar warts: economic evaluation alongside a randomised controlled trial (EVerT trial). In: Journal of Foot and Ankle Research. 2012 ; Vol. 5, No. 1:4.
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abstract = "BACKGROUND: Plantar warts (verrucae) are extremely common. Although many will spontaneously disappear without treatment, treatment may be sought for a variety of reasons such as discomfort. There are a number of different treatments for cutaneous warts, with salicylic acid and cryotherapy using liquid nitrogen being two of the most common forms of treatment. To date, no full economic evaluation of either salicylic acid or cryotherapy has been conducted based on the use of primary data in a pragmatic setting. This paper describes the cost-effectiveness analysis which was conducted alongside a pragmatic multicentre, randomised trial evaluating the clinical effectiveness of cryotherapy versus 50{\%} salicylic acid of the treatment of plantar warts. METHODS: A cost-effectiveness analysis was undertaken alongside a pragmatic multicentre, randomised controlled trial assessing the clinical effectiveness of 50{\%} salicylic acid and cryotherapy using liquid nitrogen at 12 weeks after randomisation of patients. Cost-effectiveness outcomes were expressed as the additional cost required to completely cure the plantar warts of one additional patient. A NHS perspective was taken for the analysis. RESULTS: Cryotherapy costs on average £101.17 (bias corrected and accelerated (BCA) 95{\%} CI: 85.09-117.26) more per participant over the 12 week time-frame, while there is no additional benefit, in terms of proportion of patients healed compared with salicylic acid. CONCLUSIONS: Cryotherapy is more costly and no more effective than salicylic acid",
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Stamuli, E, Cockayne, S, Hewitt, C, Hicks, K, Jayakody, S, Kang'ombe, AR, Turner, G, Thomas, K, Curran, M, Hashmi, F, McIntosh, C, McLarnon, N, Torgerson, DJ & Watt, I 2012, 'Cost-effectiveness of cryotherapy versus salicylic acid for the treatment of plantar warts: economic evaluation alongside a randomised controlled trial (EVerT trial)', Journal of Foot and Ankle Research, vol. 5, no. 1:4. https://doi.org/10.1186/1757-1146-5-4

Cost-effectiveness of cryotherapy versus salicylic acid for the treatment of plantar warts: economic evaluation alongside a randomised controlled trial (EVerT trial). / Stamuli, Eugena; Cockayne, Sarah; Hewitt, Catherine; Hicks, Kate; Jayakody, Shalmini; Kang'ombe, Arthur Ricky; Turner, Gwen; Thomas, Kim; Curran, Mike; Hashmi, Farina; McIntosh, Caroline; McLarnon, Nichola; Torgerson, David J; Watt, Ian.

In: Journal of Foot and Ankle Research, Vol. 5, No. 1:4, 27.02.2012.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Cost-effectiveness of cryotherapy versus salicylic acid for the treatment of plantar warts: economic evaluation alongside a randomised controlled trial (EVerT trial)

AU - Stamuli, Eugena

AU - Cockayne, Sarah

AU - Hewitt, Catherine

AU - Hicks, Kate

AU - Jayakody, Shalmini

AU - Kang'ombe, Arthur Ricky

AU - Turner, Gwen

AU - Thomas, Kim

AU - Curran, Mike

AU - Hashmi, Farina

AU - McIntosh, Caroline

AU - McLarnon, Nichola

AU - Torgerson, David J

AU - Watt, Ian

PY - 2012/2/27

Y1 - 2012/2/27

N2 - BACKGROUND: Plantar warts (verrucae) are extremely common. Although many will spontaneously disappear without treatment, treatment may be sought for a variety of reasons such as discomfort. There are a number of different treatments for cutaneous warts, with salicylic acid and cryotherapy using liquid nitrogen being two of the most common forms of treatment. To date, no full economic evaluation of either salicylic acid or cryotherapy has been conducted based on the use of primary data in a pragmatic setting. This paper describes the cost-effectiveness analysis which was conducted alongside a pragmatic multicentre, randomised trial evaluating the clinical effectiveness of cryotherapy versus 50% salicylic acid of the treatment of plantar warts. METHODS: A cost-effectiveness analysis was undertaken alongside a pragmatic multicentre, randomised controlled trial assessing the clinical effectiveness of 50% salicylic acid and cryotherapy using liquid nitrogen at 12 weeks after randomisation of patients. Cost-effectiveness outcomes were expressed as the additional cost required to completely cure the plantar warts of one additional patient. A NHS perspective was taken for the analysis. RESULTS: Cryotherapy costs on average £101.17 (bias corrected and accelerated (BCA) 95% CI: 85.09-117.26) more per participant over the 12 week time-frame, while there is no additional benefit, in terms of proportion of patients healed compared with salicylic acid. CONCLUSIONS: Cryotherapy is more costly and no more effective than salicylic acid

AB - BACKGROUND: Plantar warts (verrucae) are extremely common. Although many will spontaneously disappear without treatment, treatment may be sought for a variety of reasons such as discomfort. There are a number of different treatments for cutaneous warts, with salicylic acid and cryotherapy using liquid nitrogen being two of the most common forms of treatment. To date, no full economic evaluation of either salicylic acid or cryotherapy has been conducted based on the use of primary data in a pragmatic setting. This paper describes the cost-effectiveness analysis which was conducted alongside a pragmatic multicentre, randomised trial evaluating the clinical effectiveness of cryotherapy versus 50% salicylic acid of the treatment of plantar warts. METHODS: A cost-effectiveness analysis was undertaken alongside a pragmatic multicentre, randomised controlled trial assessing the clinical effectiveness of 50% salicylic acid and cryotherapy using liquid nitrogen at 12 weeks after randomisation of patients. Cost-effectiveness outcomes were expressed as the additional cost required to completely cure the plantar warts of one additional patient. A NHS perspective was taken for the analysis. RESULTS: Cryotherapy costs on average £101.17 (bias corrected and accelerated (BCA) 95% CI: 85.09-117.26) more per participant over the 12 week time-frame, while there is no additional benefit, in terms of proportion of patients healed compared with salicylic acid. CONCLUSIONS: Cryotherapy is more costly and no more effective than salicylic acid

KW - Plantar warts

KW - verrucae

KW - Cost-effectiveness analysis

KW - salicylic acid

KW - cryotherapy using liquid nitrogen

U2 - 10.1186/1757-1146-5-4

DO - 10.1186/1757-1146-5-4

M3 - Article

VL - 5

JO - Journal of Foot and Ankle Research

JF - Journal of Foot and Ankle Research

SN - 1757-1146

IS - 1:4

ER -