Abstract
The Duchenne muscular dystrophy (DMD) gene is the largest known human gene spanning a genomic range over 2Mb. It encodes multiple protein products of varying size and function.
Several studies have emerged showing that muscular dystrophy mouse models are prone to develop spontaneous soft tissue sarcomas (STS).
High DMD expression has been linked to several cancers, including low-grade glioma (LGG), improving prognosis in some and worsening prognosis in others.
Although literature has previously linked the DMD gene to numerous cancers, none have considered the many gene products produced by the DMD gene.
Dp71 is a ubiquitous dystrophin protein and the predominant DMD product in the brain.
Several studies have emerged showing that muscular dystrophy mouse models are prone to develop spontaneous soft tissue sarcomas (STS).
High DMD expression has been linked to several cancers, including low-grade glioma (LGG), improving prognosis in some and worsening prognosis in others.
Although literature has previously linked the DMD gene to numerous cancers, none have considered the many gene products produced by the DMD gene.
Dp71 is a ubiquitous dystrophin protein and the predominant DMD product in the brain.
| Original language | English |
|---|---|
| Number of pages | 1 |
| Publication status | Published - 5 Sept 2022 |
| Event | Cancer Research UK Brain Tumour Conference - London Duration: 5 Sept 2022 → 7 Sept 2022 |
Conference
| Conference | Cancer Research UK Brain Tumour Conference |
|---|---|
| City | London |
| Period | 5/09/22 → 7/09/22 |
Keywords
- Duchenne muscular dystrophy
- Dystrophin
- Dp71
- Glioma
- low grade glioma
- Brain tumour
- Biomarker
- Cancer
