Duchenne muscular dystrophy gene expression is an independent prognostic marker for IDH mutant low-grade glioma

Michael Naidoo; Leanne Jones; Benjamin Conboy; Wael Hamarneh; Darwin  D'Souza; Karen Anthony; Lee Machado

Duchenne muscular dystrophy gene expression is an independent prognostic marker for IDH mutant low-grade glioma

Michael Naidoo
, Leanne Jones
, Benjamin Conboy
, Wael Hamarneh
, Darwin D'Souza
, Karen Anthony
, Lee Machado

Research output: Contribution to Conference › Poster › peer-review

Abstract

The Duchenne muscular dystrophy (DMD) gene is the largest known human gene spanning a genomic range over 2Mb. It encodes multiple protein products of varying size and function.

Several studies have emerged showing that muscular dystrophy mouse models are prone to develop spontaneous soft tissue sarcomas (STS).

High DMD expression has been linked to several cancers, including low-grade glioma (LGG), improving prognosis in some and worsening prognosis in others.

Although literature has previously linked the DMD gene to numerous cancers, none have considered the many gene products produced by the DMD gene.

Dp71 is a ubiquitous dystrophin protein and the predominant DMD product in the brain.

Original language	English
Number of pages	1
Publication status	Published - 5 Sept 2022
Event	Cancer Research UK Brain Tumour Conference - London Duration: 5 Sept 2022 → 7 Sept 2022

Conference

Conference	Cancer Research UK Brain Tumour Conference
City	London
Period	5/09/22 → 7/09/22

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Duchenne muscular dystrophy
Dystrophin
Dp71
Glioma
low grade glioma
Brain tumour
Biomarker
Cancer

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title = "Duchenne muscular dystrophy gene expression is an independent prognostic marker for IDH mutant low-grade glioma",

abstract = "The Duchenne muscular dystrophy (DMD) gene is the largest known human gene spanning a genomic range over 2Mb. It encodes multiple protein products of varying size and function. Several studies have emerged showing that muscular dystrophy mouse models are prone to develop spontaneous soft tissue sarcomas (STS). High DMD expression has been linked to several cancers, including low-grade glioma (LGG), improving prognosis in some and worsening prognosis in others. Although literature has previously linked the DMD gene to numerous cancers, none have considered the many gene products produced by the DMD gene. Dp71 is a ubiquitous dystrophin protein and the predominant DMD product in the brain.",

keywords = "Duchenne muscular dystrophy, Dystrophin, Dp71, Glioma, low grade glioma, Brain tumour, Biomarker, Cancer",

author = "Michael Naidoo and Leanne Jones and Benjamin Conboy and Wael Hamarneh and Darwin D'Souza and Karen Anthony and Lee Machado",

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T1 - Duchenne muscular dystrophy gene expression is an independent prognostic marker for IDH mutant low-grade glioma

AU - Naidoo, Michael

AU - Jones, Leanne

AU - Conboy, Benjamin

AU - Hamarneh, Wael

AU - D'Souza, Darwin

AU - Anthony, Karen

AU - Machado, Lee

PY - 2022/9/5

Y1 - 2022/9/5

N2 - The Duchenne muscular dystrophy (DMD) gene is the largest known human gene spanning a genomic range over 2Mb. It encodes multiple protein products of varying size and function. Several studies have emerged showing that muscular dystrophy mouse models are prone to develop spontaneous soft tissue sarcomas (STS). High DMD expression has been linked to several cancers, including low-grade glioma (LGG), improving prognosis in some and worsening prognosis in others. Although literature has previously linked the DMD gene to numerous cancers, none have considered the many gene products produced by the DMD gene. Dp71 is a ubiquitous dystrophin protein and the predominant DMD product in the brain.

AB - The Duchenne muscular dystrophy (DMD) gene is the largest known human gene spanning a genomic range over 2Mb. It encodes multiple protein products of varying size and function. Several studies have emerged showing that muscular dystrophy mouse models are prone to develop spontaneous soft tissue sarcomas (STS). High DMD expression has been linked to several cancers, including low-grade glioma (LGG), improving prognosis in some and worsening prognosis in others. Although literature has previously linked the DMD gene to numerous cancers, none have considered the many gene products produced by the DMD gene. Dp71 is a ubiquitous dystrophin protein and the predominant DMD product in the brain.

KW - Duchenne muscular dystrophy

KW - Dystrophin

KW - Dp71

KW - Glioma

KW - low grade glioma

KW - Brain tumour

KW - Biomarker

KW - Cancer

M3 - Poster

T2 - Cancer Research UK Brain Tumour Conference

Y2 - 5 September 2022 through 7 September 2022

ER -

Duchenne muscular dystrophy gene expression is an independent prognostic marker for IDH mutant low-grade glioma

Abstract

Conference

UN SDGs

Keywords

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