Elevation of mitochondrial Ca2+ concentration by calcium-induced calcium release in A10 rat aortic smooth muscle cell line

Aman Nassar; Alec W. M. Simpson

doi:10.1111/j.1469-7793.2000.tb00255.x

Elevation of mitochondrial Ca2+ concentration by calcium-induced calcium release in A10 rat aortic smooth muscle cell line

Aman Nassar, Alec W. M. Simpson

Psychology & Sociology

Research output: Contribution to Conference › Paper › peer-review

Abstract

We conclude that tight coupling in the form of Ca²⁺ microdomains may also exist between ryanodine-sensitive Ca²⁺ stores and mitochondria. These data indicate Ca²⁺ - induced Ca²⁺ release (CICR) involving the ryanodine receptor leads to large elevations of [Ca²⁺]_m. CICR may therefore be important for the efficient elevation of [Ca²⁺]_m in cells that contain RyRs.

Original language	English
Pages	84P
Number of pages	85
DOIs	https://doi.org/10.1111/j.1469-7793.2000.tb00255.x
Publication status	Published - 1 Jun 2000
Event	Scientific Meeting of The Physiological Society - Imperial College, London, United Kingdom Duration: 12 Apr 2000 → 14 Apr 2000

Conference

Conference	Scientific Meeting of The Physiological Society
Country/Territory	United Kingdom
City	London
Period	12/04/00 → 14/04/00

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title = "Elevation of mitochondrial Ca2+ concentration by calcium-induced calcium release in A10 rat aortic smooth muscle cell line",

abstract = "We conclude that tight coupling in the form of Ca2+ microdomains may also exist between ryanodine-sensitive Ca2+ stores and mitochondria. These data indicate Ca2+ - induced Ca2+ release (CICR) involving the ryanodine receptor leads to large elevations of [Ca2+]m. CICR may therefore be important for the efficient elevation of [Ca2+]m in cells that contain RyRs.",

author = "Aman Nassar and Simpson, {Alec W. M.}",

year = "2000",

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doi = "10.1111/j.1469-7793.2000.tb00255.x",

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T1 - Elevation of mitochondrial Ca2+ concentration by calcium-induced calcium release in A10 rat aortic smooth muscle cell line

AU - Nassar, Aman

AU - Simpson, Alec W. M.

PY - 2000/6/1

Y1 - 2000/6/1

N2 - We conclude that tight coupling in the form of Ca2+ microdomains may also exist between ryanodine-sensitive Ca2+ stores and mitochondria. These data indicate Ca2+ - induced Ca2+ release (CICR) involving the ryanodine receptor leads to large elevations of [Ca2+]m. CICR may therefore be important for the efficient elevation of [Ca2+]m in cells that contain RyRs.

AB - We conclude that tight coupling in the form of Ca2+ microdomains may also exist between ryanodine-sensitive Ca2+ stores and mitochondria. These data indicate Ca2+ - induced Ca2+ release (CICR) involving the ryanodine receptor leads to large elevations of [Ca2+]m. CICR may therefore be important for the efficient elevation of [Ca2+]m in cells that contain RyRs.

U2 - 10.1111/j.1469-7793.2000.tb00255.x

DO - 10.1111/j.1469-7793.2000.tb00255.x

M3 - Paper

SP - 84P

T2 - Scientific Meeting of The Physiological Society

Y2 - 12 April 2000 through 14 April 2000

ER -

Elevation of mitochondrial Ca2+ concentration by calcium-induced calcium release in A10 rat aortic smooth muscle cell line

Abstract

Conference

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