GA4GH: International policies and standards for data sharing across genomic research and healthcare

Heidi L. Rehm; Angela J.H. Page; Lindsay Smith; Jeremy B. Adams; Gil Alterovitz; Lawrence J. Babb; Maxmillian P. Barkley; Michael Baudis; Michael J.S. Beauvais; Tim Beck; Jacques S. Beckmann; Sergi Beltran; David Bernick; Alexander Bernier; James K. Bonfield; Tiffany F. Boughtwood; Guillaume Bourque; Sarion R. Bowers; Anthony J. Brookes; Michael Brudno; Matthew H. Brush; David Bujold; Tony Burdett; Orion J. Buske; Moran N. Cabili; Daniel L. Cameron; Robert J. Carroll; Esmeralda Casas-Silva; Debyani Chakravarty; Bimal P. Chaudhari; Shu Hui Chen; J. Michael Cherry; Justina Chung; Melissa Cline; Hayley L. Clissold; Robert M. Cook-Deegan; Mélanie Courtot; Fiona Cunningham; Miro Cupak; Robert M. Davies; Danielle Denisko; Megan J. Doerr; Lena I. Dolman; Edward S. Dove; L. Jonathan Dursi; Stephanie O.M. Dyke; James A. Eddy; Karen Eilbeck; Kyle P. Ellrott; Susan Fairley; Khalid A. Fakhro; Helen V. Firth; Michael S. Fitzsimons; Marc Fiume; Paul Flicek; Ian M. Fore; Mallory A. Freeberg; Robert R. Freimuth; Lauren A. Fromont; Jonathan Fuerth; Clara L. Gaff; Weiniu Gan; Elena M. Ghanaim; David Glazer; Robert C. Green; Malachi Griffith; Obi L. Griffith; Robert L. Grossman; Tudor Groza; Jaime M. Guidry Auvil; Roderic Guigó; Dipayan Gupta; Melissa A. Haendel; Ada Hamosh; David P. Hansen; Reece K. Hart; Dean Mitchell Hartley; David Haussler; Rachele M. Hendricks-Sturrup; Calvin W.L. Ho; Ashley E. Hobb; Michael M. Hoffman; Oliver M. Hofmann; Petr Holub; Jacob Shujui Hsu; Jean-Pierre Hubaux; Sarah E. Hunt; Ammar Husami; Julius O. Jacobsen; Saumya S. Jamuar; Elizabeth L. Janes; Francis Jeanson; Aina Jené; Amber L. Johns; Yann Joly; Steven J.M. Jones; Alexander Kanitz; Kazuto Kato; Thomas M. Keane; Kristina Kekesi-Lafrance; Jerome Kelleher; Giselle Kerry; Seik-Soon Khor; Bartha M. Knoppers; Melissa A. Konopko; Kenjiro Kosaki; Martin Kuba; Jonathan Lawson; Rasko Leinonen; Stephanie Li; Michael F. Lin; Mikael Linden; Xianglin Liu; Isuru Udara Liyanage; Javier Lopez; Anneke M. Lucassen; Michael Lukowski; Alice L. Mann; John Marshall; Michele Mattioni; Alejandro Metke-Jimenez; Anna Middleton; Richard J. Milne; Fruzsina Molnár-Gábor; Nicola Mulder; Monica C. Munoz-Torres; Rishi Nag; Hidewaki Nakagawa; Jamal Nasir; Arcadi Navarro; Tristan H. Nelson; Ania Niewielska; Amy Nisselle; Jeffrey Niu; Tommi H. Nyrönen; Brian D. O’Connor; Sabine Oesterle; Soichi Ogishima; Vivian Ota Wang; Laura A.D. Paglione; Emilio Palumbo; Helen E. Parkinson; Anthony A. Philippakis; Angel D. Pizarro; Andreas Prlic; Jordi Rambla; Augusto Rendon; Renee A. Rider; Peter N. Robinson; Kurt W. Rodarmer; Laura Lyman Rodriguez; Alan F. Rubin; Manuel Rueda; Gregory A. Rushton; Rosalyn S. Ryan; Gary I. Saunders; Helen Schuilenburg; Torsten Schwede; Serena Scollen; Alexander Senf; Nathan C. Sheffield; Neerjah Skantharajah; Albert V. Smith; Heidi J. Sofia; Dylan Spalding; Amanda B. Spurdle; Zornitza Stark; Lincoln D. Stein; Makoto Suematsu; Patrick Tan; Jonathan A. Tedds; Alastair A. Thomson; Adrian Thorogood; Timothy L. Tickle; Katsushi Tokunaga; Juha Törnroos; David Torrents; Sean Upchurch; Alfonso Valencia; Roman Valls Guimera; Jessica Vamathevan; Susheel Varma; Danya F. Vears; Coby Viner; Craig Voisin; Alex H. Wagner; Susan E. Wallace; Brian P. Walsh; Marc S. Williams; Eva C. Winkler; Barbara J. Wold; Grant M. Wood; J. Patrick Woolley; Chisato Yamasaki; Andrew D. Yates; Christina K. Yung; Lyndon J. Zass; Ksenia Zaytseva; Junjun Zhang; Peter Goodhand; Kathryn North; Ewan Birney

doi:https://doi.org/10.1016/j.xgen.2021.100029

GA4GH: International policies and standards for data sharing across genomic research and healthcare

Heidi L. Rehm, Angela J.H. Page, Lindsay Smith, Jeremy B. Adams, Gil Alterovitz, Lawrence J. Babb, Maxmillian P. Barkley, Michael Baudis, Michael J.S. Beauvais, Tim Beck, Jacques S. Beckmann, Sergi Beltran, David Bernick, Alexander Bernier, James K. Bonfield, Tiffany F. Boughtwood, Guillaume Bourque, Sarion R. Bowers, Anthony J. Brookes, Michael BrudnoMatthew H. Brush, David Bujold, Tony Burdett, Orion J. Buske, Moran N. Cabili, Daniel L. Cameron, Robert J. Carroll, Esmeralda Casas-Silva, Debyani Chakravarty, Bimal P. Chaudhari, Shu Hui Chen, J. Michael Cherry, Justina Chung, Melissa Cline, Hayley L. Clissold, Robert M. Cook-Deegan, Mélanie Courtot, Fiona Cunningham, Miro Cupak, Robert M. Davies, Danielle Denisko, Megan J. Doerr, Lena I. Dolman, Edward S. Dove, L. Jonathan Dursi, Stephanie O.M. Dyke, James A. Eddy, Karen Eilbeck, Kyle P. Ellrott, Susan Fairley, Khalid A. Fakhro, Helen V. Firth, Michael S. Fitzsimons, Marc Fiume, Paul Flicek, Ian M. Fore, Mallory A. Freeberg, Robert R. Freimuth, Lauren A. Fromont, Jonathan Fuerth, Clara L. Gaff, Weiniu Gan, Elena M. Ghanaim, David Glazer, Robert C. Green, Malachi Griffith, Obi L. Griffith, Robert L. Grossman, Tudor Groza, Jaime M. Guidry Auvil, Roderic Guigó, Dipayan Gupta, Melissa A. Haendel, Ada Hamosh, David P. Hansen, Reece K. Hart, Dean Mitchell Hartley, David Haussler, Rachele M. Hendricks-Sturrup, Calvin W.L. Ho, Ashley E. Hobb, Michael M. Hoffman, Oliver M. Hofmann, Petr Holub, Jacob Shujui Hsu, Jean-Pierre Hubaux, Sarah E. Hunt, Ammar Husami, Julius O. Jacobsen, Saumya S. Jamuar, Elizabeth L. Janes, Francis Jeanson, Aina Jené, Amber L. Johns, Yann Joly, Steven J.M. Jones, Alexander Kanitz, Kazuto Kato, Thomas M. Keane, Kristina Kekesi-Lafrance, Jerome Kelleher, Giselle Kerry, Seik-Soon Khor, Bartha M. Knoppers, Melissa A. Konopko, Kenjiro Kosaki, Martin Kuba, Jonathan Lawson, Rasko Leinonen, Stephanie Li, Michael F. Lin, Mikael Linden, Xianglin Liu, Isuru Udara Liyanage, Javier Lopez, Anneke M. Lucassen, Michael Lukowski, Alice L. Mann, John Marshall, Michele Mattioni, Alejandro Metke-Jimenez, Anna Middleton, Richard J. Milne, Fruzsina Molnár-Gábor, Nicola Mulder, Monica C. Munoz-Torres, Rishi Nag, Hidewaki Nakagawa, Jamal Nasir, Arcadi Navarro, Tristan H. Nelson, Ania Niewielska, Amy Nisselle, Jeffrey Niu, Tommi H. Nyrönen, Brian D. O’Connor, Sabine Oesterle, Soichi Ogishima, Vivian Ota Wang, Laura A.D. Paglione, Emilio Palumbo, Helen E. Parkinson, Anthony A. Philippakis, Angel D. Pizarro, Andreas Prlic, Jordi Rambla, Augusto Rendon, Renee A. Rider, Peter N. Robinson, Kurt W. Rodarmer, Laura Lyman Rodriguez, Alan F. Rubin, Manuel Rueda, Gregory A. Rushton, Rosalyn S. Ryan, Gary I. Saunders, Helen Schuilenburg, Torsten Schwede, Serena Scollen, Alexander Senf, Nathan C. Sheffield, Neerjah Skantharajah, Albert V. Smith, Heidi J. Sofia, Dylan Spalding, Amanda B. Spurdle, Zornitza Stark, Lincoln D. Stein, Makoto Suematsu, Patrick Tan, Jonathan A. Tedds, Alastair A. Thomson, Adrian Thorogood, Timothy L. Tickle, Katsushi Tokunaga, Juha Törnroos, David Torrents, Sean Upchurch, Alfonso Valencia, Roman Valls Guimera, Jessica Vamathevan, Susheel Varma, Danya F. Vears, Coby Viner, Craig Voisin, Alex H. Wagner, Susan E. Wallace, Brian P. Walsh, Marc S. Williams, Eva C. Winkler, Barbara J. Wold, Grant M. Wood, J. Patrick Woolley, Chisato Yamasaki, Andrew D. Yates, Christina K. Yung, Lyndon J. Zass, Ksenia Zaytseva, Junjun Zhang, Peter Goodhand, Kathryn North, Ewan Birney

Science

Research output: Contribution to Journal › Article › peer-review

Abstract

The Global Alliance for Genomics and Health (GA4GH) aims to accelerate biomedical advances by enabling the responsible sharing of clinical and genomic data through both harmonized data aggregation and federated approaches. The decreasing cost of genomic sequencing (along with other genome-wide molecular assays) and increasing evidence of its clinical utility will soon drive the generation of sequence data from tens of millions of humans, with increasing levels of diversity. In this perspective, we present the GA4GH strategies for addressing the major challenges of this data revolution. We describe the GA4GH organization, which is fueled by the development efforts of eight Work Streams and informed by the needs of 24 Driver Projects and other key stakeholders. We present the GA4GH suite of secure, interoperable technical standards and policy frameworks and review the current status of standards, their relevance to key domains of research and clinical care, and future plans of GA4GH. Broad international participation in building, adopting, and deploying GA4GH standards and frameworks will catalyze an unprecedented effort in data sharing that will be critical to advancing genomic medicine and ensuring that all populations can access its benefits.

Original language	English
Article number	100029
Journal	Cell Genomics
Volume	1
Issue number	2
Early online date	10 Nov 2021
DOIs	https://doi.org/10.1016/j.xgen.2021.100029 https://doi.org/10.1016/j.xgen.2021.100029
Publication status	Published - 10 Nov 2021

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Rehm, H. L., Page, A. J. H., Smith, L., Adams, J. B., Alterovitz, G., Babb, L. J., Barkley, M. P., Baudis, M., Beauvais, M. J. S., Beck, T., Beckmann, J. S., Beltran, S., Bernick, D., Bernier, A., Bonfield, J. K., Boughtwood, T. F., Bourque, G., Bowers, S. R., Brookes, A. J., ... Birney, E. (2021). GA4GH: International policies and standards for data sharing across genomic research and healthcare. Cell Genomics, 1(2), [100029]. https://doi.org/10.1016/j.xgen.2021.100029, https://doi.org/10.1016/j.xgen.2021.100029

@article{1341db4d29fa4792b1f99864db2218ad,

title = "GA4GH: International policies and standards for data sharing across genomic research and healthcare",

abstract = "The Global Alliance for Genomics and Health (GA4GH) aims to accelerate biomedical advances by enabling the responsible sharing of clinical and genomic data through both harmonized data aggregation and federated approaches. The decreasing cost of genomic sequencing (along with other genome-wide molecular assays) and increasing evidence of its clinical utility will soon drive the generation of sequence data from tens of millions of humans, with increasing levels of diversity. In this perspective, we present the GA4GH strategies for addressing the major challenges of this data revolution. We describe the GA4GH organization, which is fueled by the development efforts of eight Work Streams and informed by the needs of 24 Driver Projects and other key stakeholders. We present the GA4GH suite of secure, interoperable technical standards and policy frameworks and review the current status of standards, their relevance to key domains of research and clinical care, and future plans of GA4GH. Broad international participation in building, adopting, and deploying GA4GH standards and frameworks will catalyze an unprecedented effort in data sharing that will be critical to advancing genomic medicine and ensuring that all populations can access its benefits.",

author = "Rehm, {Heidi L.} and Page, {Angela J.H.} and Lindsay Smith and Adams, {Jeremy B.} and Gil Alterovitz and Babb, {Lawrence J.} and Barkley, {Maxmillian P.} and Michael Baudis and Beauvais, {Michael J.S.} and Tim Beck and Beckmann, {Jacques S.} and Sergi Beltran and David Bernick and Alexander Bernier and Bonfield, {James K.} and Boughtwood, {Tiffany F.} and Guillaume Bourque and Bowers, {Sarion R.} and Brookes, {Anthony J.} and Michael Brudno and Brush, {Matthew H.} and David Bujold and Tony Burdett and Buske, {Orion J.} and Cabili, {Moran N.} and Cameron, {Daniel L.} and Carroll, {Robert J.} and Esmeralda Casas-Silva and Debyani Chakravarty and Chaudhari, {Bimal P.} and Chen, {Shu Hui} and Cherry, {J. Michael} and Justina Chung and Melissa Cline and Clissold, {Hayley L.} and Cook-Deegan, {Robert M.} and M{\'e}lanie Courtot and Fiona Cunningham and Miro Cupak and Davies, {Robert M.} and Danielle Denisko and Doerr, {Megan J.} and Dolman, {Lena I.} and Dove, {Edward S.} and Dursi, {L. Jonathan} and Dyke, {Stephanie O.M.} and Eddy, {James A.} and Karen Eilbeck and Ellrott, {Kyle P.} and Susan Fairley and Fakhro, {Khalid A.} and Firth, {Helen V.} and Fitzsimons, {Michael S.} and Marc Fiume and Paul Flicek and Fore, {Ian M.} and Freeberg, {Mallory A.} and Freimuth, {Robert R.} and Fromont, {Lauren A.} and Jonathan Fuerth and Gaff, {Clara L.} and Weiniu Gan and Ghanaim, {Elena M.} and David Glazer and Green, {Robert C.} and Malachi Griffith and Griffith, {Obi L.} and Grossman, {Robert L.} and Tudor Groza and {Guidry Auvil}, {Jaime M.} and Roderic Guig{\'o} and Dipayan Gupta and Haendel, {Melissa A.} and Ada Hamosh and Hansen, {David P.} and Hart, {Reece K.} and Hartley, {Dean Mitchell} and David Haussler and Hendricks-Sturrup, {Rachele M.} and Ho, {Calvin W.L.} and Hobb, {Ashley E.} and Hoffman, {Michael M.} and Hofmann, {Oliver M.} and Petr Holub and Hsu, {Jacob Shujui} and Jean-Pierre Hubaux and Hunt, {Sarah E.} and Ammar Husami and Jacobsen, {Julius O.} and Jamuar, {Saumya S.} and Janes, {Elizabeth L.} and Francis Jeanson and Aina Jen{\'e} and Johns, {Amber L.} and Yann Joly and Jones, {Steven J.M.} and Alexander Kanitz and Kazuto Kato and Keane, {Thomas M.} and Kristina Kekesi-Lafrance and Jerome Kelleher and Giselle Kerry and Seik-Soon Khor and Knoppers, {Bartha M.} and Konopko, {Melissa A.} and Kenjiro Kosaki and Martin Kuba and Jonathan Lawson and Rasko Leinonen and Stephanie Li and Lin, {Michael F.} and Mikael Linden and Xianglin Liu and Liyanage, {Isuru Udara} and Javier Lopez and Lucassen, {Anneke M.} and Michael Lukowski and Mann, {Alice L.} and John Marshall and Michele Mattioni and Alejandro Metke-Jimenez and Anna Middleton and Milne, {Richard J.} and Fruzsina Moln{\'a}r-G{\'a}bor and Nicola Mulder and Munoz-Torres, {Monica C.} and Rishi Nag and Hidewaki Nakagawa and Jamal Nasir and Arcadi Navarro and Nelson, {Tristan H.} and Ania Niewielska and Amy Nisselle and Jeffrey Niu and Nyr{\"o}nen, {Tommi H.} and O{\textquoteright}Connor, {Brian D.} and Sabine Oesterle and Soichi Ogishima and {Ota Wang}, Vivian and Paglione, {Laura A.D.} and Emilio Palumbo and Parkinson, {Helen E.} and Philippakis, {Anthony A.} and Pizarro, {Angel D.} and Andreas Prlic and Jordi Rambla and Augusto Rendon and Rider, {Renee A.} and Robinson, {Peter N.} and Rodarmer, {Kurt W.} and Rodriguez, {Laura Lyman} and Rubin, {Alan F.} and Manuel Rueda and Rushton, {Gregory A.} and Ryan, {Rosalyn S.} and Saunders, {Gary I.} and Helen Schuilenburg and Torsten Schwede and Serena Scollen and Alexander Senf and Sheffield, {Nathan C.} and Neerjah Skantharajah and Smith, {Albert V.} and Sofia, {Heidi J.} and Dylan Spalding and Spurdle, {Amanda B.} and Zornitza Stark and Stein, {Lincoln D.} and Makoto Suematsu and Patrick Tan and Tedds, {Jonathan A.} and Thomson, {Alastair A.} and Adrian Thorogood and Tickle, {Timothy L.} and Katsushi Tokunaga and Juha T{\"o}rnroos and David Torrents and Sean Upchurch and Alfonso Valencia and Guimera, {Roman Valls} and Jessica Vamathevan and Susheel Varma and Vears, {Danya F.} and Coby Viner and Craig Voisin and Wagner, {Alex H.} and Wallace, {Susan E.} and Walsh, {Brian P.} and Williams, {Marc S.} and Winkler, {Eva C.} and Wold, {Barbara J.} and Wood, {Grant M.} and Woolley, {J. Patrick} and Chisato Yamasaki and Yates, {Andrew D.} and Yung, {Christina K.} and Zass, {Lyndon J.} and Ksenia Zaytseva and Junjun Zhang and Peter Goodhand and Kathryn North and Ewan Birney",

year = "2021",

month = nov,

day = "10",

doi = "https://doi.org/10.1016/j.xgen.2021.100029",

language = "English",

volume = "1",

journal = "Cell Genomics",

issn = "2666-979X",

publisher = "Cell Press",

number = "2",

}

Rehm, HL, Page, AJH, Smith, L, Adams, JB, Alterovitz, G, Babb, LJ, Barkley, MP, Baudis, M, Beauvais, MJS, Beck, T, Beckmann, JS, Beltran, S, Bernick, D, Bernier, A, Bonfield, JK, Boughtwood, TF, Bourque, G, Bowers, SR, Brookes, AJ, Brudno, M, Brush, MH, Bujold, D, Burdett, T, Buske, OJ, Cabili, MN, Cameron, DL, Carroll, RJ, Casas-Silva, E, Chakravarty, D, Chaudhari, BP, Chen, SH, Cherry, JM, Chung, J, Cline, M, Clissold, HL, Cook-Deegan, RM, Courtot, M, Cunningham, F, Cupak, M, Davies, RM, Denisko, D, Doerr, MJ, Dolman, LI, Dove, ES, Dursi, LJ, Dyke, SOM, Eddy, JA, Eilbeck, K, Ellrott, KP, Fairley, S, Fakhro, KA, Firth, HV, Fitzsimons, MS, Fiume, M, Flicek, P, Fore, IM, Freeberg, MA, Freimuth, RR, Fromont, LA, Fuerth, J, Gaff, CL, Gan, W, Ghanaim, EM, Glazer, D, Green, RC, Griffith, M, Griffith, OL, Grossman, RL, Groza, T, Guidry Auvil, JM, Guigó, R, Gupta, D, Haendel, MA, Hamosh, A, Hansen, DP, Hart, RK, Hartley, DM, Haussler, D, Hendricks-Sturrup, RM, Ho, CWL, Hobb, AE, Hoffman, MM, Hofmann, OM, Holub, P, Hsu, JS, Hubaux, J-P, Hunt, SE, Husami, A, Jacobsen, JO, Jamuar, SS, Janes, EL, Jeanson, F, Jené, A, Johns, AL, Joly, Y, Jones, SJM, Kanitz, A, Kato, K, Keane, TM, Kekesi-Lafrance, K, Kelleher, J, Kerry, G, Khor, S-S, Knoppers, BM, Konopko, MA, Kosaki, K, Kuba, M, Lawson, J, Leinonen, R, Li, S, Lin, MF, Linden, M, Liu, X, Liyanage, IU, Lopez, J, Lucassen, AM, Lukowski, M, Mann, AL, Marshall, J, Mattioni, M, Metke-Jimenez, A, Middleton, A, Milne, RJ, Molnár-Gábor, F, Mulder, N, Munoz-Torres, MC, Nag, R, Nakagawa, H, Nasir, J, Navarro, A, Nelson, TH, Niewielska, A, Nisselle, A, Niu, J, Nyrönen, TH, O’Connor, BD, Oesterle, S, Ogishima, S, Ota Wang, V, Paglione, LAD, Palumbo, E, Parkinson, HE, Philippakis, AA, Pizarro, AD, Prlic, A, Rambla, J, Rendon, A, Rider, RA, Robinson, PN, Rodarmer, KW, Rodriguez, LL, Rubin, AF, Rueda, M, Rushton, GA, Ryan, RS, Saunders, GI, Schuilenburg, H, Schwede, T, Scollen, S, Senf, A, Sheffield, NC, Skantharajah, N, Smith, AV, Sofia, HJ, Spalding, D, Spurdle, AB, Stark, Z, Stein, LD, Suematsu, M, Tan, P, Tedds, JA, Thomson, AA, Thorogood, A, Tickle, TL, Tokunaga, K, Törnroos, J, Torrents, D, Upchurch, S, Valencia, A, Guimera, RV, Vamathevan, J, Varma, S, Vears, DF, Viner, C, Voisin, C, Wagner, AH, Wallace, SE, Walsh, BP, Williams, MS, Winkler, EC, Wold, BJ, Wood, GM, Woolley, JP, Yamasaki, C, Yates, AD, Yung, CK, Zass, LJ, Zaytseva, K, Zhang, J, Goodhand, P, North, K & Birney, E 2021, 'GA4GH: International policies and standards for data sharing across genomic research and healthcare', Cell Genomics, vol. 1, no. 2, 100029. https://doi.org/10.1016/j.xgen.2021.100029, https://doi.org/10.1016/j.xgen.2021.100029

TY - JOUR

T1 - GA4GH: International policies and standards for data sharing across genomic research and healthcare

AU - Rehm, Heidi L.

AU - Page, Angela J.H.

AU - Smith, Lindsay

AU - Adams, Jeremy B.

AU - Alterovitz, Gil

AU - Babb, Lawrence J.

AU - Barkley, Maxmillian P.

AU - Baudis, Michael

AU - Beauvais, Michael J.S.

AU - Beck, Tim

AU - Beckmann, Jacques S.

AU - Beltran, Sergi

AU - Bernick, David

AU - Bernier, Alexander

AU - Bonfield, James K.

AU - Boughtwood, Tiffany F.

AU - Bourque, Guillaume

AU - Bowers, Sarion R.

AU - Brookes, Anthony J.

AU - Brudno, Michael

AU - Brush, Matthew H.

AU - Bujold, David

AU - Burdett, Tony

AU - Buske, Orion J.

AU - Cabili, Moran N.

AU - Cameron, Daniel L.

AU - Carroll, Robert J.

AU - Casas-Silva, Esmeralda

AU - Chakravarty, Debyani

AU - Chaudhari, Bimal P.

AU - Chen, Shu Hui

AU - Cherry, J. Michael

AU - Chung, Justina

AU - Cline, Melissa

AU - Clissold, Hayley L.

AU - Cook-Deegan, Robert M.

AU - Courtot, Mélanie

AU - Cunningham, Fiona

AU - Cupak, Miro

AU - Davies, Robert M.

AU - Denisko, Danielle

AU - Doerr, Megan J.

AU - Dolman, Lena I.

AU - Dove, Edward S.

AU - Dursi, L. Jonathan

AU - Dyke, Stephanie O.M.

AU - Eddy, James A.

AU - Eilbeck, Karen

AU - Ellrott, Kyle P.

AU - Fairley, Susan

AU - Fakhro, Khalid A.

AU - Firth, Helen V.

AU - Fitzsimons, Michael S.

AU - Fiume, Marc

AU - Flicek, Paul

AU - Fore, Ian M.

AU - Freeberg, Mallory A.

AU - Freimuth, Robert R.

AU - Fromont, Lauren A.

AU - Fuerth, Jonathan

AU - Gaff, Clara L.

AU - Gan, Weiniu

AU - Ghanaim, Elena M.

AU - Glazer, David

AU - Green, Robert C.

AU - Griffith, Malachi

AU - Griffith, Obi L.

AU - Grossman, Robert L.

AU - Groza, Tudor

AU - Guidry Auvil, Jaime M.

AU - Guigó, Roderic

AU - Gupta, Dipayan

AU - Haendel, Melissa A.

AU - Hamosh, Ada

AU - Hansen, David P.

AU - Hart, Reece K.

AU - Hartley, Dean Mitchell

AU - Haussler, David

AU - Hendricks-Sturrup, Rachele M.

AU - Ho, Calvin W.L.

AU - Hobb, Ashley E.

AU - Hoffman, Michael M.

AU - Hofmann, Oliver M.

AU - Holub, Petr

AU - Hsu, Jacob Shujui

AU - Hubaux, Jean-Pierre

AU - Hunt, Sarah E.

AU - Husami, Ammar

AU - Jacobsen, Julius O.

AU - Jamuar, Saumya S.

AU - Janes, Elizabeth L.

AU - Jeanson, Francis

AU - Jené, Aina

AU - Johns, Amber L.

AU - Joly, Yann

AU - Jones, Steven J.M.

AU - Kanitz, Alexander

AU - Kato, Kazuto

AU - Keane, Thomas M.

AU - Kekesi-Lafrance, Kristina

AU - Kelleher, Jerome

AU - Kerry, Giselle

AU - Khor, Seik-Soon

AU - Knoppers, Bartha M.

AU - Konopko, Melissa A.

AU - Kosaki, Kenjiro

AU - Kuba, Martin

AU - Lawson, Jonathan

AU - Leinonen, Rasko

AU - Li, Stephanie

AU - Lin, Michael F.

AU - Linden, Mikael

AU - Liu, Xianglin

AU - Liyanage, Isuru Udara

AU - Lopez, Javier

AU - Lucassen, Anneke M.

AU - Lukowski, Michael

AU - Mann, Alice L.

AU - Marshall, John

AU - Mattioni, Michele

AU - Metke-Jimenez, Alejandro

AU - Middleton, Anna

AU - Milne, Richard J.

AU - Molnár-Gábor, Fruzsina

AU - Mulder, Nicola

AU - Munoz-Torres, Monica C.

AU - Nag, Rishi

AU - Nakagawa, Hidewaki

AU - Nasir, Jamal

AU - Navarro, Arcadi

AU - Nelson, Tristan H.

AU - Niewielska, Ania

AU - Nisselle, Amy

AU - Niu, Jeffrey

AU - Nyrönen, Tommi H.

AU - O’Connor, Brian D.

AU - Oesterle, Sabine

AU - Ogishima, Soichi

AU - Ota Wang, Vivian

AU - Paglione, Laura A.D.

AU - Palumbo, Emilio

AU - Parkinson, Helen E.

AU - Philippakis, Anthony A.

AU - Pizarro, Angel D.

AU - Prlic, Andreas

AU - Rambla, Jordi

AU - Rendon, Augusto

AU - Rider, Renee A.

AU - Robinson, Peter N.

AU - Rodarmer, Kurt W.

AU - Rodriguez, Laura Lyman

AU - Rubin, Alan F.

AU - Rueda, Manuel

AU - Rushton, Gregory A.

AU - Ryan, Rosalyn S.

AU - Saunders, Gary I.

AU - Schuilenburg, Helen

AU - Schwede, Torsten

AU - Scollen, Serena

AU - Senf, Alexander

AU - Sheffield, Nathan C.

AU - Skantharajah, Neerjah

AU - Smith, Albert V.

AU - Sofia, Heidi J.

AU - Spalding, Dylan

AU - Spurdle, Amanda B.

AU - Stark, Zornitza

AU - Stein, Lincoln D.

AU - Suematsu, Makoto

AU - Tan, Patrick

AU - Tedds, Jonathan A.

AU - Thomson, Alastair A.

AU - Thorogood, Adrian

AU - Tickle, Timothy L.

AU - Tokunaga, Katsushi

AU - Törnroos, Juha

AU - Torrents, David

AU - Upchurch, Sean

AU - Valencia, Alfonso

AU - Guimera, Roman Valls

AU - Vamathevan, Jessica

AU - Varma, Susheel

AU - Vears, Danya F.

AU - Viner, Coby

AU - Voisin, Craig

AU - Wagner, Alex H.

AU - Wallace, Susan E.

AU - Walsh, Brian P.

AU - Williams, Marc S.

AU - Winkler, Eva C.

AU - Wold, Barbara J.

AU - Wood, Grant M.

AU - Woolley, J. Patrick

AU - Yamasaki, Chisato

AU - Yates, Andrew D.

AU - Yung, Christina K.

AU - Zass, Lyndon J.

AU - Zaytseva, Ksenia

AU - Zhang, Junjun

AU - Goodhand, Peter

AU - North, Kathryn

AU - Birney, Ewan

PY - 2021/11/10

Y1 - 2021/11/10

N2 - The Global Alliance for Genomics and Health (GA4GH) aims to accelerate biomedical advances by enabling the responsible sharing of clinical and genomic data through both harmonized data aggregation and federated approaches. The decreasing cost of genomic sequencing (along with other genome-wide molecular assays) and increasing evidence of its clinical utility will soon drive the generation of sequence data from tens of millions of humans, with increasing levels of diversity. In this perspective, we present the GA4GH strategies for addressing the major challenges of this data revolution. We describe the GA4GH organization, which is fueled by the development efforts of eight Work Streams and informed by the needs of 24 Driver Projects and other key stakeholders. We present the GA4GH suite of secure, interoperable technical standards and policy frameworks and review the current status of standards, their relevance to key domains of research and clinical care, and future plans of GA4GH. Broad international participation in building, adopting, and deploying GA4GH standards and frameworks will catalyze an unprecedented effort in data sharing that will be critical to advancing genomic medicine and ensuring that all populations can access its benefits.

AB - The Global Alliance for Genomics and Health (GA4GH) aims to accelerate biomedical advances by enabling the responsible sharing of clinical and genomic data through both harmonized data aggregation and federated approaches. The decreasing cost of genomic sequencing (along with other genome-wide molecular assays) and increasing evidence of its clinical utility will soon drive the generation of sequence data from tens of millions of humans, with increasing levels of diversity. In this perspective, we present the GA4GH strategies for addressing the major challenges of this data revolution. We describe the GA4GH organization, which is fueled by the development efforts of eight Work Streams and informed by the needs of 24 Driver Projects and other key stakeholders. We present the GA4GH suite of secure, interoperable technical standards and policy frameworks and review the current status of standards, their relevance to key domains of research and clinical care, and future plans of GA4GH. Broad international participation in building, adopting, and deploying GA4GH standards and frameworks will catalyze an unprecedented effort in data sharing that will be critical to advancing genomic medicine and ensuring that all populations can access its benefits.

U2 - https://doi.org/10.1016/j.xgen.2021.100029

DO - https://doi.org/10.1016/j.xgen.2021.100029

M3 - Article

VL - 1

JO - Cell Genomics

JF - Cell Genomics

SN - 2666-979X

IS - 2

M1 - 100029

ER -

GA4GH: International policies and standards for data sharing across genomic research and healthcare

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