Abstract
The current study presents an effective and simple strategy to obtain stable porous scaffolds from gelatin via a gas foaming method. The technique exploits the intrinsic foaming ability of gelatin in the presence of CO2 to obtain a porous structure stabilised with glutaraldehyde. The produced scaffolds were characterised using physical and mechanical characterisation methods. The results showed that gas foaming may allow the tailoring of the 3-dimensional structure of the scaffolds with an interconnected porous structure. To assess the effectiveness of the preparation method in mitigating the potential cytotoxicity risk of using glutaraldehyde as a crosslinker, direct and in-direct cytotoxicity assays were performed at different concentrations of glutaraldehyde. The results indicate the potential of the gas foaming method, in the preparation of viable tissue engineering scaffolds.
Original language | English |
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Pages (from-to) | 63-70 |
Number of pages | 8 |
Journal | Materials Science and Engineering: C |
Volume | 48 |
Early online date | 11 Nov 2014 |
DOIs | |
Publication status | Published - 1 Mar 2015 |
Keywords
- Gelatin
- Gas foaming
- Crosslinking
- Tensile strength
- Denaturation temperature
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Dr Alexander Lehner
- University of Northampton, Science - Senior Lecturer in Human Nutrition
- Centre for Physical Activity and Life Sciences
Person: Academic