TY - JOUR
T1 - H2O2 Self-Supplied MoS2/CaO2 Nanozyme Hydrogel with Near-Infrared Photothermal Synergetic Cascade Peroxidase-Like Activity for Wound Disinfection
AU - Huang, Jinyi
AU - Ullah, Ihsan
AU - Chen, Linjie
AU - Peng, Ke
AU - Ou, Yujie
AU - Gong, Zehua
AU - Wu, Aimin
AU - He, Zhimin
AU - Yin, Wenyan
AU - Li, Huaqiong
PY - 2024/10/6
Y1 - 2024/10/6
N2 - AbstractIn wound healing and clinical anti‐infection therapy, the current feasibility of nanocatalysts is extremely limited because of inadequate reactive oxygen species (ROS) generation. Herein, a novel H2O2 self‐supplying nanocomposite (M/C/AEK) consists of molybdenum disulfide (MoS2) decorated with calcium peroxide (CaO2) prepared at ambient temperature and encapsulated in AEK hydrogel. In the presence of H2O2 and poly(vinyl pyrrolidone) (PVP), CaO2 nanoclusters, ≈30 nm, are anchored on the MoS2 surface. MoS2/CaO2 can induce both a cascaded peroxidase (POD)‐like and catalase (CAT)‐like catalytic activity to produce toxic hydroxyl radicals through self‐supplied H2O2 and O2 responsive to the faintly acidic environment of acute wounds. The POD‐like activity is increased under acidic compared with neutral conditions, allowing selective treatment of acute, slightly acidic wounds while avoiding the side effects of high‐concentration antibacterial agents on normal tissues. The high near‐infrared photothermal effect synergistically with POD‐like/CAT‐like activity of MoS2/CaO2 boosts the production of more ROS to eradicate Staphylococcus aureus and Escherichia coli bacteria (98.6% and 98.9%) effectively and selectively stimulate wound healing. The porous M/C/AEK hydrogel in the wound microenvironment can efficiently capture bacteria, and its Ca2+ ions and keratin stimulate healing, revealing excellent potential in advanced wound care and infection control therapies.
AB - AbstractIn wound healing and clinical anti‐infection therapy, the current feasibility of nanocatalysts is extremely limited because of inadequate reactive oxygen species (ROS) generation. Herein, a novel H2O2 self‐supplying nanocomposite (M/C/AEK) consists of molybdenum disulfide (MoS2) decorated with calcium peroxide (CaO2) prepared at ambient temperature and encapsulated in AEK hydrogel. In the presence of H2O2 and poly(vinyl pyrrolidone) (PVP), CaO2 nanoclusters, ≈30 nm, are anchored on the MoS2 surface. MoS2/CaO2 can induce both a cascaded peroxidase (POD)‐like and catalase (CAT)‐like catalytic activity to produce toxic hydroxyl radicals through self‐supplied H2O2 and O2 responsive to the faintly acidic environment of acute wounds. The POD‐like activity is increased under acidic compared with neutral conditions, allowing selective treatment of acute, slightly acidic wounds while avoiding the side effects of high‐concentration antibacterial agents on normal tissues. The high near‐infrared photothermal effect synergistically with POD‐like/CAT‐like activity of MoS2/CaO2 boosts the production of more ROS to eradicate Staphylococcus aureus and Escherichia coli bacteria (98.6% and 98.9%) effectively and selectively stimulate wound healing. The porous M/C/AEK hydrogel in the wound microenvironment can efficiently capture bacteria, and its Ca2+ ions and keratin stimulate healing, revealing excellent potential in advanced wound care and infection control therapies.
KW - clinical anti-infection therapy
KW - self-supplying nanocomposite
KW - stimulate wound healing
KW - MoS2/CaO2
KW - peroxidase-like activity,
KW - photothermal effect
UR - https://www.x-mol.net/paper/article/1843457990731948032
U2 - 10.1002/adhm.202402393
DO - 10.1002/adhm.202402393
M3 - Article
SN - 2192-2640
VL - 13
JO - Advanced healthcare materials
JF - Advanced healthcare materials
IS - 10
M1 - 2402393
ER -