Kidney Beam - a cost-effective digital intervention to improve mental health

Sharlene A. Greenwood; Juliet Briggs; Christy Walkin; Emmanuel Mangahis; Hannah Young; Ellen Castle; Roseanne Billany; Elham Asgari; Sunil Bhandari; Nicolette Bishop; Kate Bramham; James Burton; Jackie Campbell; Joseph Chilcot; Nicola Cooper; Vashist Deelchand; Matthew Graham-Brown; Lynda Haggis; Alexander Hamilton; Mark Jesky; Philip Kalra; Pelagia Koufaki; Kieran McCafferty; Andrew Nixon; Helen Noble; Zoe Saynor; Maarten Taal; James Tollitt; David Wheeler; Thomas Wilkinson; Hannah Worboys; Jamie Macdonald

doi:10.1016/j.ekir.2024.08.030

Kidney Beam - a cost-effective digital intervention to improve mental health

Sharlene A. Greenwood^*, Juliet Briggs, Christy Walkin, Emmanuel Mangahis, Hannah Young, Ellen Castle, Roseanne Billany, Elham Asgari, Sunil Bhandari, Nicolette Bishop, Kate Bramham, James Burton, Jackie Campbell, Joseph Chilcot, Nicola Cooper, Vashist Deelchand, Matthew Graham-Brown, Lynda Haggis, Alexander Hamilton, Mark JeskyPhilip Kalra, Pelagia Koufaki, Kieran McCafferty, Andrew Nixon, Helen Noble, Zoe Saynor, Maarten Taal, James Tollitt, David Wheeler, Thomas Wilkinson, Hannah Worboys, Jamie Macdonald

^*Corresponding author for this work

Health, Education & Society - Research

Research output: Contribution to Journal › Article › peer-review

Abstract

There is inequity in provision of physical rehabilitation services for people living with chronic kidney disease (CKD). The Kidney BEAM trial evaluated the clinical value and cost effectiveness of a physical activity digital health intervention in CKD. In a single-blind, 11 centre, randomised controlled trial, 340 adult participants with CKD were randomly assigned to either the Kidney BEAM physical activity digital health intervention or a waitlist control. The primary outcomes were the difference in the Kidney Disease Quality of Life Short Form 1.3 Mental Component Summary (KDQoL-SF1.3 MCS) between intervention and control groups at 6 months, and cost-effectiveness. At 6 months there was a significant difference in mean adjusted change in KDQoL MCS score between Kidney BEAM and waitlist control (intention-to-treat adjusted mean: 5.9 {95% confidence interval: 4.4 to 7.5} arbitrary units, p<0.0001), and a 93% and 98% chance of the intervention being cost-effective at a willingness to pay threshold of £20,000 and £30,000 per quality-adjusted life year gained. In conclusion, the Kidney BEAM physical activity digital health intervention is a clinically valuable and cost-effective means to improve mental health related quality of life in people with CKD (trial registration no. NCT04872933).

Original language	English
Number of pages	14
Journal	Kidney International Reports
Volume	9
Issue number	11
DOIs	https://doi.org/10.1016/j.ekir.2024.08.030
Publication status	Published - 2 Sept 2024

Bibliographical note

Authorship followed ICMJE guidelines. SAG, HY, REB, NB, JB, EMC, ZLS, HN, AH, KB, ACN, MPMG-B, TJW and JM were responsible for the inception and design of the project and prepared the manuscript. SAG, HY, REB, NB, JB, EMC, AH, VD, HN, ACN, TJW, JC, NC, HW, SB, JOB, PK, PAK, DCW, JT, MJ, MWT, EA, KM, ZLS, MPMG-B, and JM contributed to the design of the study, provided methodological input, and wrote the manuscript text and prepared Tables 1 to 3. All authors reviewed the manuscript.

Data Access Statement

Data collected during the study, including deidentified participant data will be made available on reasonable request, and following trial steering committee approval, by contacting corresponding author on [email protected]. The study protocol, statistical analysis plan, and other study forms can be obtained by visiting BMC Nephrology.19 The health economic analysis plan can be found in supplemental files.

Keywords

Chronic kidney disease
Digital health intervention
RCT
Cost-effectiveness
Physical activity
Quality of life

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

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Cite this

Greenwood, S. A., Briggs, J., Walkin, C., Mangahis, E., Young, H., Castle, E., Billany, R., Asgari, E., Bhandari, S., Bishop, N., Bramham, K., Burton, J., Campbell, J., Chilcot, J., Cooper, N., Deelchand, V., Graham-Brown, M., Haggis, L., Hamilton, A., ... Macdonald, J. (2024). Kidney Beam - a cost-effective digital intervention to improve mental health. Kidney International Reports, 9(11). https://doi.org/10.1016/j.ekir.2024.08.030

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title = "Kidney Beam - a cost-effective digital intervention to improve mental health",

abstract = "There is inequity in provision of physical rehabilitation services for people living with chronic kidney disease (CKD). The Kidney BEAM trial evaluated the clinical value and cost effectiveness of a physical activity digital health intervention in CKD. In a single-blind, 11 centre, randomised controlled trial, 340 adult participants with CKD were randomly assigned to either the Kidney BEAM physical activity digital health intervention or a waitlist control. The primary outcomes were the difference in the Kidney Disease Quality of Life Short Form 1.3 Mental Component Summary (KDQoL-SF1.3 MCS) between intervention and control groups at 6 months, and cost-effectiveness. At 6 months there was a significant difference in mean adjusted change in KDQoL MCS score between Kidney BEAM and waitlist control (intention-to-treat adjusted mean: 5.9 {95% confidence interval: 4.4 to 7.5} arbitrary units, p<0.0001), and a 93% and 98% chance of the intervention being cost-effective at a willingness to pay threshold of £20,000 and £30,000 per quality-adjusted life year gained. In conclusion, the Kidney BEAM physical activity digital health intervention is a clinically valuable and cost-effective means to improve mental health related quality of life in people with CKD (trial registration no. NCT04872933). ",

keywords = "Chronic kidney disease, Digital health intervention, RCT, Cost-effectiveness, Physical activity, Quality of life",

author = "Greenwood, {Sharlene A.} and Juliet Briggs and Christy Walkin and Emmanuel Mangahis and Hannah Young and Ellen Castle and Roseanne Billany and Elham Asgari and Sunil Bhandari and Nicolette Bishop and Kate Bramham and James Burton and Jackie Campbell and Joseph Chilcot and Nicola Cooper and Vashist Deelchand and Matthew Graham-Brown and Lynda Haggis and Alexander Hamilton and Mark Jesky and Philip Kalra and Pelagia Koufaki and Kieran McCafferty and Andrew Nixon and Helen Noble and Zoe Saynor and Maarten Taal and James Tollitt and David Wheeler and Thomas Wilkinson and Hannah Worboys and Jamie Macdonald",

note = "Authorship followed ICMJE guidelines. SAG, HY, REB, NB, JB, EMC, ZLS, HN, AH, KB, ACN, MPMG-B, TJW and JM were responsible for the inception and design of the project and prepared the manuscript. SAG, HY, REB, NB, JB, EMC, AH, VD, HN, ACN, TJW, JC, NC, HW, SB, JOB, PK, PAK, DCW, JT, MJ, MWT, EA, KM, ZLS, MPMG-B, and JM contributed to the design of the study, provided methodological input, and wrote the manuscript text and prepared Tables 1 to 3. All authors reviewed the manuscript.",

year = "2024",

month = sep,

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doi = "10.1016/j.ekir.2024.08.030",

language = "English",

volume = "9",

journal = "Kidney International Reports",

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Greenwood, SA, Briggs, J, Walkin, C, Mangahis, E, Young, H, Castle, E, Billany, R, Asgari, E, Bhandari, S, Bishop, N, Bramham, K, Burton, J, Campbell, J, Chilcot, J, Cooper, N, Deelchand, V, Graham-Brown, M, Haggis, L, Hamilton, A, Jesky, M, Kalra, P, Koufaki, P, McCafferty, K, Nixon, A, Noble, H, Saynor, Z, Taal, M, Tollitt, J, Wheeler, D, Wilkinson, T, Worboys, H & Macdonald, J 2024, 'Kidney Beam - a cost-effective digital intervention to improve mental health', Kidney International Reports, vol. 9, no. 11. https://doi.org/10.1016/j.ekir.2024.08.030

TY - JOUR

T1 - Kidney Beam - a cost-effective digital intervention to improve mental health

AU - Greenwood, Sharlene A.

AU - Briggs, Juliet

AU - Walkin, Christy

AU - Mangahis, Emmanuel

AU - Young, Hannah

AU - Castle, Ellen

AU - Billany, Roseanne

AU - Asgari, Elham

AU - Bhandari, Sunil

AU - Bishop, Nicolette

AU - Bramham, Kate

AU - Burton, James

AU - Campbell, Jackie

AU - Chilcot, Joseph

AU - Cooper, Nicola

AU - Deelchand, Vashist

AU - Graham-Brown, Matthew

AU - Haggis, Lynda

AU - Hamilton, Alexander

AU - Jesky, Mark

AU - Kalra, Philip

AU - Koufaki, Pelagia

AU - McCafferty, Kieran

AU - Nixon, Andrew

AU - Noble, Helen

AU - Saynor, Zoe

AU - Taal, Maarten

AU - Tollitt, James

AU - Wheeler, David

AU - Wilkinson, Thomas

AU - Worboys, Hannah

AU - Macdonald, Jamie

N1 - Authorship followed ICMJE guidelines. SAG, HY, REB, NB, JB, EMC, ZLS, HN, AH, KB, ACN, MPMG-B, TJW and JM were responsible for the inception and design of the project and prepared the manuscript. SAG, HY, REB, NB, JB, EMC, AH, VD, HN, ACN, TJW, JC, NC, HW, SB, JOB, PK, PAK, DCW, JT, MJ, MWT, EA, KM, ZLS, MPMG-B, and JM contributed to the design of the study, provided methodological input, and wrote the manuscript text and prepared Tables 1 to 3. All authors reviewed the manuscript.

PY - 2024/9/2

Y1 - 2024/9/2

N2 - There is inequity in provision of physical rehabilitation services for people living with chronic kidney disease (CKD). The Kidney BEAM trial evaluated the clinical value and cost effectiveness of a physical activity digital health intervention in CKD. In a single-blind, 11 centre, randomised controlled trial, 340 adult participants with CKD were randomly assigned to either the Kidney BEAM physical activity digital health intervention or a waitlist control. The primary outcomes were the difference in the Kidney Disease Quality of Life Short Form 1.3 Mental Component Summary (KDQoL-SF1.3 MCS) between intervention and control groups at 6 months, and cost-effectiveness. At 6 months there was a significant difference in mean adjusted change in KDQoL MCS score between Kidney BEAM and waitlist control (intention-to-treat adjusted mean: 5.9 {95% confidence interval: 4.4 to 7.5} arbitrary units, p<0.0001), and a 93% and 98% chance of the intervention being cost-effective at a willingness to pay threshold of £20,000 and £30,000 per quality-adjusted life year gained. In conclusion, the Kidney BEAM physical activity digital health intervention is a clinically valuable and cost-effective means to improve mental health related quality of life in people with CKD (trial registration no. NCT04872933).

AB - There is inequity in provision of physical rehabilitation services for people living with chronic kidney disease (CKD). The Kidney BEAM trial evaluated the clinical value and cost effectiveness of a physical activity digital health intervention in CKD. In a single-blind, 11 centre, randomised controlled trial, 340 adult participants with CKD were randomly assigned to either the Kidney BEAM physical activity digital health intervention or a waitlist control. The primary outcomes were the difference in the Kidney Disease Quality of Life Short Form 1.3 Mental Component Summary (KDQoL-SF1.3 MCS) between intervention and control groups at 6 months, and cost-effectiveness. At 6 months there was a significant difference in mean adjusted change in KDQoL MCS score between Kidney BEAM and waitlist control (intention-to-treat adjusted mean: 5.9 {95% confidence interval: 4.4 to 7.5} arbitrary units, p<0.0001), and a 93% and 98% chance of the intervention being cost-effective at a willingness to pay threshold of £20,000 and £30,000 per quality-adjusted life year gained. In conclusion, the Kidney BEAM physical activity digital health intervention is a clinically valuable and cost-effective means to improve mental health related quality of life in people with CKD (trial registration no. NCT04872933).

KW - Chronic kidney disease

KW - Digital health intervention

KW - RCT

KW - Cost-effectiveness

KW - Physical activity

KW - Quality of life

UR - https://pure.northampton.ac.uk/en/publications/db9a76db-3565-4540-be5c-18d8c8cde54f

UR - https://www.sciencedirect.com/science/article/pii/S2468024924019156

U2 - 10.1016/j.ekir.2024.08.030

DO - 10.1016/j.ekir.2024.08.030

M3 - Article

C2 - 39534205

SN - 2468-0249

VL - 9

JO - Kidney International Reports

JF - Kidney International Reports

IS - 11

ER -

Kidney Beam - a cost-effective digital intervention to improve mental health

Abstract

Bibliographical note

Data Access Statement

Keywords

UN SDGs

Access to Document

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