Abstract
There is inequity in provision of physical rehabilitation services for people living with chronic kidney disease (CKD). The Kidney BEAM trial evaluated the clinical value and cost effectiveness of a physical activity digital health intervention in CKD. In a single-blind, 11 centre, randomised controlled trial, 340 adult participants with CKD were randomly assigned to either the Kidney BEAM physical activity digital health intervention or a waitlist control. The primary outcomes were the difference in the Kidney Disease Quality of Life Short Form 1.3 Mental Component Summary (KDQoL-SF1.3 MCS) between intervention and control groups at 6 months, and cost-effectiveness. At 6 months there was a significant difference in mean adjusted change in KDQoL MCS score between Kidney BEAM and waitlist control (intention-to-treat adjusted mean: 5.9 {95% confidence interval: 4.4 to 7.5} arbitrary units, p<0.0001), and a 93% and 98% chance of the intervention being cost-effective at a willingness to pay threshold of £20,000 and £30,000 per quality-adjusted life year gained. In conclusion, the Kidney BEAM physical activity digital health intervention is a clinically valuable and cost-effective means to improve mental health related quality of life in people with CKD (trial registration no. NCT04872933).
Original language | English |
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Number of pages | 14 |
Journal | Kidney International Reports |
DOIs | |
Publication status | Published - 2 Sept 2024 |
Bibliographical note
Authorship followed ICMJE guidelines. SAG, HY, REB, NB, JB, EMC, ZLS, HN, AH, KB, ACN, MPMG-B, TJW and JM were responsible for the inception and design of the project and prepared the manuscript. SAG, HY, REB, NB, JB, EMC, AH, VD, HN, ACN, TJW, JC, NC, HW, SB, JOB, PK, PAK, DCW, JT, MJ, MWT, EA, KM, ZLS, MPMG-B, and JM contributed to the design of the study, provided methodological input, and wrote the manuscript text and prepared Tables 1 to 3. All authors reviewed the manuscript.Data Access Statement
Data collected during the study, including deidentified participant data will be made available on reasonable request, and following trial steering committee approval, by contacting corresponding author on [email protected]. The study protocol, statistical analysis plan, and other study forms can be obtained by visiting BMC Nephrology.19 The health economic analysis plan can be found in supplemental files.Keywords
- Chronic kidney disease
- Digital health intervention
- RCT
- Cost-effectiveness
- Physical activity
- Quality of life