In Brazil, since 2009, there has been an ever increasing widespread of the blaKPC-2 gene, mainly in Klebsiella pneumoniae. This study aims to assess the molecular epidemiology and genetic background of this gene in Enterobacteriaceae (non-K. pneumoniae) species from 9 Brazilian states between 2009 and 2011. Three hundred eighty-seven isolates were analyzed exhibiting nonsusceptibility to carbapenems, in which the blaKPC-2 gene was detected in 21.4%. By disk diffusion and E-test, these isolates exhibited high rates of resistance to most of the antimicrobials tested, including tigecycline (45.6% nonsusceptible) and polymyxin B (16.5%), the most resistant species being Enterobacter aerogenes and Enterobacter cloacae. We found great clonal diversity and a variety of blaKPC-2-carrying plasmids, all of them exhibiting a partial Tn4401 structure. Therefore, this study demonstrates the dissemination of KPC-2 in 9 Enterobacteriaceae species, including species that were not previously described such as Pantoea agglomerans and Providencia stuartii.
|Title of host publication||Taxon|
|Number of pages||12|
|Publication status||Published - 2007|
- pollination biology
- species interactions
Ollerton, J., Killick, A., Lamborn, E., Watts, S., & Whiston, M. (2007). Multiple Meanings and Modes : On the Many Ways to Be a Generalist Flower Linked references are available on JSTOR for this article : | INTRODUCTION. In Taxon (pp. 717-728). (Taxon; Vol. 56). https://doi.org/10.1016/j.diagmicrobio.2015.04.002