Population genetics of immune-related multilocus copy number variation in Native Americans

Luciana Zuccherato, Silvana Schneider, Eduardo Tarazona-Santos, Robert J Hardwick, Douglas Berg, Helen Bogle, Mateus Gouveia, Lee Machado, Moara Machado, Fernanda Rodrigues-Soares, Giordano Soares-Souza, Diego Togni, Roxana Zamudio, Robert Gilman, Denise Duarte, Edward J Hollox, Maira R Rodrigues

Research output: Contribution to JournalArticlepeer-review


While multiallelic copy number variation (mCNV) loci are a major component of genomic variation, quantifying the individual copy number of a locus and defining genotypes is challenging. Few methods exist to study how mCNV genetic diversity is apportioned within and between populations (i.e., to define the population genetic structure of mCNV). These inferences are critical in populations with a small effective size, such as Amerindians, that may not fit the Hardy-Weinberg model due to inbreeding, assortative mating, population subdivision, natural selection or a combination of these evolutionary factors. We propose a likelihood-based method that simultaneously infers mCNV allele frequencies and the population structure parameter , which quantifies the departure of homozygosity from the Hardy-Weinberg expectation. This method is implemented in the freely available software CNVice, which also infers individual genotypes using information from both the population and from trios, if available. We studied the population genetics of five immune-related mCNV loci associated with complex diseases (beta-defensins, CCL3L1/CCL4L1, FCGR3A, FCGR3B, and FCGR2C) in 12 traditional Native American populations and found that the population structure parameters inferred for these mCNVs are comparable to but lower than those for SNPs studied in the same populations.
Original languageEnglish
JournalJournal of the Royal Society Interface
Issue number128
Publication statusPublished - 29 Mar 2017


  • Amerindians
  • Immunity
  • genomic structural variation
  • population structure
  • profiled likelihood


Dive into the research topics of 'Population genetics of immune-related multilocus copy number variation in Native Americans'. Together they form a unique fingerprint.

Cite this