Sex chromosome complement regulates habit formation

Jennifer J Quinn; Paul K Hitchcott; Elizabeth A Umeda; Arthur P Arnold; Jane Taylor

doi:10.1038/nn1994

Sex chromosome complement regulates habit formation

Jennifer J Quinn, Paul K Hitchcott, Elizabeth A Umeda, Arthur P Arnold, Jane Taylor

Research output: Contribution to Journal › Article › peer-review

Abstract

Sex differences in brain function and behavior are regularly attributed to gonadal hormones. Some brain sexual dimorphisms, however, are direct actions of sex chromosome genes that are not mediated by gonadal hormones. We used mice in which sex chromosome complement (XX versus XY) and gonadal sex (ovaries versus testes) were independent, and found that XX mice showed faster food-reinforced instrumental habit formation than XY mice, regardless of gonadal phenotype.

Original language	English
Pages (from-to)	1398-1400
Number of pages	3
Journal	Nature Neuroscience
Volume	10
Issue number	11
Early online date	21 Oct 2007
DOIs	https://doi.org/10.1038/nn1994
Publication status	Published - Nov 2007
Externally published	Yes

Keywords

Animals
Antimanic Agents/pharmacology
Avoidance Learning/drug effects
Behavior, Animal
Disorders of Sex Development
Female
Genes, sry/genetics
Habits
Lithium Chloride/pharmacology
Male
Mice
Mice, Transgenic
Sex Characteristics
Sex Chromosomes/genetics
Sex Determination Processes
X Chromosome
Y Chromosome

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10.1038/nn1994

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title = "Sex chromosome complement regulates habit formation",

abstract = "Sex differences in brain function and behavior are regularly attributed to gonadal hormones. Some brain sexual dimorphisms, however, are direct actions of sex chromosome genes that are not mediated by gonadal hormones. We used mice in which sex chromosome complement (XX versus XY) and gonadal sex (ovaries versus testes) were independent, and found that XX mice showed faster food-reinforced instrumental habit formation than XY mice, regardless of gonadal phenotype.",

keywords = "Animals, Antimanic Agents/pharmacology, Avoidance Learning/drug effects, Behavior, Animal, Disorders of Sex Development, Female, Genes, sry/genetics, Habits, Lithium Chloride/pharmacology, Male, Mice, Mice, Transgenic, Sex Characteristics, Sex Chromosomes/genetics, Sex Determination Processes, X Chromosome, Y Chromosome",

author = "Quinn, {Jennifer J} and Hitchcott, {Paul K} and Umeda, {Elizabeth A} and Arnold, {Arthur P} and Jane Taylor",

year = "2007",

month = nov,

doi = "10.1038/nn1994",

language = "English",

volume = "10",

pages = "1398--1400",

journal = "Nature Neuroscience",

issn = "1097-6256",

publisher = "Nature Publishing Group",

number = "11",

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AU - Quinn, Jennifer J

AU - Hitchcott, Paul K

AU - Umeda, Elizabeth A

AU - Arnold, Arthur P

AU - Taylor, Jane

PY - 2007/11

Y1 - 2007/11

N2 - Sex differences in brain function and behavior are regularly attributed to gonadal hormones. Some brain sexual dimorphisms, however, are direct actions of sex chromosome genes that are not mediated by gonadal hormones. We used mice in which sex chromosome complement (XX versus XY) and gonadal sex (ovaries versus testes) were independent, and found that XX mice showed faster food-reinforced instrumental habit formation than XY mice, regardless of gonadal phenotype.

AB - Sex differences in brain function and behavior are regularly attributed to gonadal hormones. Some brain sexual dimorphisms, however, are direct actions of sex chromosome genes that are not mediated by gonadal hormones. We used mice in which sex chromosome complement (XX versus XY) and gonadal sex (ovaries versus testes) were independent, and found that XX mice showed faster food-reinforced instrumental habit formation than XY mice, regardless of gonadal phenotype.

KW - Animals

KW - Antimanic Agents/pharmacology

KW - Avoidance Learning/drug effects

KW - Behavior, Animal

KW - Disorders of Sex Development

KW - Female

KW - Genes, sry/genetics

KW - Habits

KW - Lithium Chloride/pharmacology

KW - Male

KW - Mice

KW - Mice, Transgenic

KW - Sex Characteristics

KW - Sex Chromosomes/genetics

KW - Sex Determination Processes

KW - X Chromosome

KW - Y Chromosome

U2 - 10.1038/nn1994

DO - 10.1038/nn1994

M3 - Article

C2 - 17952068

SN - 1097-6256

VL - 10

SP - 1398

EP - 1400

JO - Nature Neuroscience

JF - Nature Neuroscience

IS - 11

ER -

Sex chromosome complement regulates habit formation

Abstract

Keywords

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