T cell homing to nasopharyngeal carcinoma

Greg Parsonage, Lee Machado, Jan Wai-Ying Hui, Tilo T Schmaler, Meenarani Balasothy, Andrew Van Hasselt, Lex Vlantis, Edwin Pun Hui, Anthony T C Chan, Kwok-Wai Lo, S P Lee

Research output: Contribution to conference typesAbstractResearch

Abstract

Undifferentiated nasopharyngeal carcinoma (NPC) is a very good candidate disease for treatment with adoptive T cell transfer. Uniformly Epstein-Barr virus (EBV)+, these tumours reportedly have functional antigen processing and presentation machinery and express viral proteins that contain known cytolytic T cell target epitopes. This raises the possibility that boosting relevant EBV-specific T cell immunity in NPC patients might defeat the tumour. The persistent nature of EBV infection may also encourage the long-term survival of therapeutically administered virus-specific cells. However, efficient delivery of tumour-specific T cells from the circulation to solid tumour tissue is a clear requirement for effective cellular therapy, yet the mechanisms by which T cells gain entry to NPC tumours have not yet been determined. The malignant cells of NPC are usually associated with a substantial lymphoid infiltrate mainly consisting of T cells. Using unmanipulated diagnostic biopsy samples, we have characterised chemokine receptor expression (CR) on tumour-infiltrating T cells, and established whether specific chemokine ligands are detectable at the NPC tumour site. We found that functional CXCR6 and CCR5 were expressed on tumour infiltrating T cells, consistent with the presence of specific ligands for these receptors at the tumour site. Furthermore, our data suggests that effector and regulatory cells may use shared homing mechanisms to gain entry to NPC tumours.
Original languageEnglish
Publication statusPublished - 1 Jan 2010
Event14th Biennial Conference of the International Association for Research on Epstein-Barr Virus and Associated Diseases - University of Birmingham
Duration: 1 Jan 2010 → …

Conference

Conference14th Biennial Conference of the International Association for Research on Epstein-Barr Virus and Associated Diseases
Period1/01/10 → …

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T-Lymphocytes
Neoplasms
Antigen Presentation
Human Herpesvirus 4
Nasopharyngeal carcinoma
Ligands
Epstein-Barr Virus Infections
T-Lymphocyte Epitopes
Adoptive Transfer
Chemokine Receptors
Viral Proteins
Chemokines
Immunity
Viruses
Carcinoma
Biopsy
Survival
Therapeutics

Cite this

Parsonage, G., Machado, L., Hui, J. W-Y., Schmaler, T. T., Balasothy, M., Van Hasselt, A., ... Lee, S. P. (2010). T cell homing to nasopharyngeal carcinoma. Abstract from 14th Biennial Conference of the International Association for Research on Epstein-Barr Virus and Associated Diseases, .
Parsonage, Greg ; Machado, Lee ; Hui, Jan Wai-Ying ; Schmaler, Tilo T ; Balasothy, Meenarani ; Van Hasselt, Andrew ; Vlantis, Lex ; Hui, Edwin Pun ; Chan, Anthony T C ; Lo, Kwok-Wai ; Lee, S P. / T cell homing to nasopharyngeal carcinoma. Abstract from 14th Biennial Conference of the International Association for Research on Epstein-Barr Virus and Associated Diseases, .
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title = "T cell homing to nasopharyngeal carcinoma",
abstract = "Undifferentiated nasopharyngeal carcinoma (NPC) is a very good candidate disease for treatment with adoptive T cell transfer. Uniformly Epstein-Barr virus (EBV)+, these tumours reportedly have functional antigen processing and presentation machinery and express viral proteins that contain known cytolytic T cell target epitopes. This raises the possibility that boosting relevant EBV-specific T cell immunity in NPC patients might defeat the tumour. The persistent nature of EBV infection may also encourage the long-term survival of therapeutically administered virus-specific cells. However, efficient delivery of tumour-specific T cells from the circulation to solid tumour tissue is a clear requirement for effective cellular therapy, yet the mechanisms by which T cells gain entry to NPC tumours have not yet been determined. The malignant cells of NPC are usually associated with a substantial lymphoid infiltrate mainly consisting of T cells. Using unmanipulated diagnostic biopsy samples, we have characterised chemokine receptor expression (CR) on tumour-infiltrating T cells, and established whether specific chemokine ligands are detectable at the NPC tumour site. We found that functional CXCR6 and CCR5 were expressed on tumour infiltrating T cells, consistent with the presence of specific ligands for these receptors at the tumour site. Furthermore, our data suggests that effector and regulatory cells may use shared homing mechanisms to gain entry to NPC tumours.",
author = "Greg Parsonage and Lee Machado and Hui, {Jan Wai-Ying} and Schmaler, {Tilo T} and Meenarani Balasothy and {Van Hasselt}, Andrew and Lex Vlantis and Hui, {Edwin Pun} and Chan, {Anthony T C} and Kwok-Wai Lo and Lee, {S P}",
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language = "English",
note = "14th Biennial Conference of the International Association for Research on Epstein-Barr Virus and Associated Diseases ; Conference date: 01-01-2010",

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Parsonage, G, Machado, L, Hui, JW-Y, Schmaler, TT, Balasothy, M, Van Hasselt, A, Vlantis, L, Hui, EP, Chan, ATC, Lo, K-W & Lee, SP 2010, 'T cell homing to nasopharyngeal carcinoma' 14th Biennial Conference of the International Association for Research on Epstein-Barr Virus and Associated Diseases, 1/01/10, .

T cell homing to nasopharyngeal carcinoma. / Parsonage, Greg; Machado, Lee; Hui, Jan Wai-Ying; Schmaler, Tilo T; Balasothy, Meenarani; Van Hasselt, Andrew; Vlantis, Lex; Hui, Edwin Pun; Chan, Anthony T C; Lo, Kwok-Wai; Lee, S P.

2010. Abstract from 14th Biennial Conference of the International Association for Research on Epstein-Barr Virus and Associated Diseases, .

Research output: Contribution to conference typesAbstractResearch

TY - CONF

T1 - T cell homing to nasopharyngeal carcinoma

AU - Parsonage, Greg

AU - Machado, Lee

AU - Hui, Jan Wai-Ying

AU - Schmaler, Tilo T

AU - Balasothy, Meenarani

AU - Van Hasselt, Andrew

AU - Vlantis, Lex

AU - Hui, Edwin Pun

AU - Chan, Anthony T C

AU - Lo, Kwok-Wai

AU - Lee, S P

PY - 2010/1/1

Y1 - 2010/1/1

N2 - Undifferentiated nasopharyngeal carcinoma (NPC) is a very good candidate disease for treatment with adoptive T cell transfer. Uniformly Epstein-Barr virus (EBV)+, these tumours reportedly have functional antigen processing and presentation machinery and express viral proteins that contain known cytolytic T cell target epitopes. This raises the possibility that boosting relevant EBV-specific T cell immunity in NPC patients might defeat the tumour. The persistent nature of EBV infection may also encourage the long-term survival of therapeutically administered virus-specific cells. However, efficient delivery of tumour-specific T cells from the circulation to solid tumour tissue is a clear requirement for effective cellular therapy, yet the mechanisms by which T cells gain entry to NPC tumours have not yet been determined. The malignant cells of NPC are usually associated with a substantial lymphoid infiltrate mainly consisting of T cells. Using unmanipulated diagnostic biopsy samples, we have characterised chemokine receptor expression (CR) on tumour-infiltrating T cells, and established whether specific chemokine ligands are detectable at the NPC tumour site. We found that functional CXCR6 and CCR5 were expressed on tumour infiltrating T cells, consistent with the presence of specific ligands for these receptors at the tumour site. Furthermore, our data suggests that effector and regulatory cells may use shared homing mechanisms to gain entry to NPC tumours.

AB - Undifferentiated nasopharyngeal carcinoma (NPC) is a very good candidate disease for treatment with adoptive T cell transfer. Uniformly Epstein-Barr virus (EBV)+, these tumours reportedly have functional antigen processing and presentation machinery and express viral proteins that contain known cytolytic T cell target epitopes. This raises the possibility that boosting relevant EBV-specific T cell immunity in NPC patients might defeat the tumour. The persistent nature of EBV infection may also encourage the long-term survival of therapeutically administered virus-specific cells. However, efficient delivery of tumour-specific T cells from the circulation to solid tumour tissue is a clear requirement for effective cellular therapy, yet the mechanisms by which T cells gain entry to NPC tumours have not yet been determined. The malignant cells of NPC are usually associated with a substantial lymphoid infiltrate mainly consisting of T cells. Using unmanipulated diagnostic biopsy samples, we have characterised chemokine receptor expression (CR) on tumour-infiltrating T cells, and established whether specific chemokine ligands are detectable at the NPC tumour site. We found that functional CXCR6 and CCR5 were expressed on tumour infiltrating T cells, consistent with the presence of specific ligands for these receptors at the tumour site. Furthermore, our data suggests that effector and regulatory cells may use shared homing mechanisms to gain entry to NPC tumours.

M3 - Abstract

ER -

Parsonage G, Machado L, Hui JW-Y, Schmaler TT, Balasothy M, Van Hasselt A et al. T cell homing to nasopharyngeal carcinoma. 2010. Abstract from 14th Biennial Conference of the International Association for Research on Epstein-Barr Virus and Associated Diseases, .