Tau mRNA is present in axonal RNA granules and is associated with elongation factor 1A

Tony Malmqvist, Karen Anthony, Jean-Marc Gallo

Research output: Contribution to journalArticleResearchpeer-review

Abstract

The microtubule-associated protein tau is predominantly localized in the axonal compartment over the entire length of the axon in neurons. The mechanisms responsible for the localization of tau in axons at long distance from the cell body are not properly understood. Using fluorescence in situ hybridization, we show that tau mRNA is present in the central and distal parts of the axons of cultured rat cortical neurons. Axonal tau mRNA is associated with granules which are distributed throughout the entire length of the axon, including the growth cone. We also show that tau mRNA-containing axonal particles are associated with elongation factor 1A, a component of the protein translation machinery. The presence of tau mRNA in axons might be at least part of the process by which tau is localized to distal axons.
Original languageEnglish
Pages (from-to)22-27
Number of pages6
JournalBrain Research
Volume1584
Early online date2 Jan 2014
DOIs
Publication statusPublished - 10 Oct 2014

Fingerprint

Peptide Elongation Factors
Axons
RNA
Messenger RNA
Neurons
Growth Cones
Microtubule-Associated Proteins
Protein Biosynthesis
Fluorescence In Situ Hybridization

Keywords

  • Axon
  • Tau
  • eEF1A
  • mRNA

Cite this

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abstract = "The microtubule-associated protein tau is predominantly localized in the axonal compartment over the entire length of the axon in neurons. The mechanisms responsible for the localization of tau in axons at long distance from the cell body are not properly understood. Using fluorescence in situ hybridization, we show that tau mRNA is present in the central and distal parts of the axons of cultured rat cortical neurons. Axonal tau mRNA is associated with granules which are distributed throughout the entire length of the axon, including the growth cone. We also show that tau mRNA-containing axonal particles are associated with elongation factor 1A, a component of the protein translation machinery. The presence of tau mRNA in axons might be at least part of the process by which tau is localized to distal axons.",
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Tau mRNA is present in axonal RNA granules and is associated with elongation factor 1A. / Malmqvist, Tony; Anthony, Karen; Gallo, Jean-Marc.

In: Brain Research, Vol. 1584, 10.10.2014, p. 22-27.

Research output: Contribution to journalArticleResearchpeer-review

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