Young onset dementia: A scoping review of key pointers to diagnostic accuracy

Jacqueline Parkes, Janet Carter*, Mary O'Malley, Jan Oyebode, Vasileios Stamou, Jenny La Fontaine

*Corresponding author for this work

Research output: Contribution to conference typesPaperResearchpeer-review

32 Downloads (Pure)

Abstract

Background
Routine psychiatric assessments tailored to older patients are often insufficient to identify the complexity of presentation in younger patients with dementia. Significant overlap between psychiatric disorders and neurodegenerative disease means that high rates of prior incorrect psychiatric diagnosis are common. Long delays to diagnosis, misdiagnosis and lack of knowledge from professionals are key concerns. No specific practice guidelines exist for diagnosis of young onset dementia (YOD).

Aim
The review evaluates the current evidence about best practice in diagnosis to guide thorough assessment of the complex presentations of YOD with a view to upskilling professionals in the field.

Method
A comprehensive search of the literature adopting a scoping review methodology was conducted regarding essential elements of diagnosis in YOD, over and above those in current diagnostic criteria for disease subtypes. This methodology was chosen because research in this area is sparse and not amenable to a traditional systematic review.

Results
The quality of evidence identified is variable with the majority provided from expert opinion and evidence is lacking on some topics. Evidence appears weighted towards diagnosis in fronto-temporal dementia (FTD) and its subtypes and young onset Alzheimer’s disease (AD).

Conclusion
The literature demonstrates that a clinically rigorous and systematic approach is necessary in order to avoid mis- or under-diagnosis for younger people. The advent of new disease modifying treatments necessitates clinicians in the field to improve knowledge of new imaging techniques and genetics, with the goal of improving training and practice, and highlights the need for quality indicators and alignment of diagnostic procedures across clinical settings.
Original languageEnglish
DOIs
Publication statusE-pub ahead of print - 4 Jun 2019

Fingerprint

Dementia
Practice Guidelines
Psychiatry
Genetic Techniques
Expert Testimony
Diagnostic Errors
Mental Disorders
Neurodegenerative Diseases
Alzheimer Disease
Research

Keywords

  • Young Onset Dementia
  • Diagnostic accuracy
  • Assessment
  • Review
  • Accuracy

Cite this

Parkes, Jacqueline ; Carter, Janet ; O'Malley, Mary ; Oyebode, Jan ; Stamou, Vasileios ; La Fontaine, Jenny. / Young onset dementia: A scoping review of key pointers to diagnostic accuracy.
@conference{2f69b16b079d4a9598c07e7df6717f20,
title = "Young onset dementia: A scoping review of key pointers to diagnostic accuracy",
abstract = "BackgroundRoutine psychiatric assessments tailored to older patients are often insufficient to identify the complexity of presentation in younger patients with dementia. Significant overlap between psychiatric disorders and neurodegenerative disease means that high rates of prior incorrect psychiatric diagnosis are common. Long delays to diagnosis, misdiagnosis and lack of knowledge from professionals are key concerns. No specific practice guidelines exist for diagnosis of young onset dementia (YOD). Aim The review evaluates the current evidence about best practice in diagnosis to guide thorough assessment of the complex presentations of YOD with a view to upskilling professionals in the field.Method A comprehensive search of the literature adopting a scoping review methodology was conducted regarding essential elements of diagnosis in YOD, over and above those in current diagnostic criteria for disease subtypes. This methodology was chosen because research in this area is sparse and not amenable to a traditional systematic review.Results The quality of evidence identified is variable with the majority provided from expert opinion and evidence is lacking on some topics. Evidence appears weighted towards diagnosis in fronto-temporal dementia (FTD) and its subtypes and young onset Alzheimer’s disease (AD). ConclusionThe literature demonstrates that a clinically rigorous and systematic approach is necessary in order to avoid mis- or under-diagnosis for younger people. The advent of new disease modifying treatments necessitates clinicians in the field to improve knowledge of new imaging techniques and genetics, with the goal of improving training and practice, and highlights the need for quality indicators and alignment of diagnostic procedures across clinical settings.",
keywords = "Young Onset Dementia, Diagnostic accuracy, Assessment, Review, Accuracy",
author = "Jacqueline Parkes and Janet Carter and Mary O'Malley and Jan Oyebode and Vasileios Stamou and {La Fontaine}, Jenny",
year = "2019",
month = "6",
day = "4",
doi = "10.1192/bjo.2019.36",
language = "English",

}

Young onset dementia: A scoping review of key pointers to diagnostic accuracy. / Parkes, Jacqueline; Carter, Janet; O'Malley, Mary; Oyebode, Jan; Stamou, Vasileios; La Fontaine, Jenny.

2019.

Research output: Contribution to conference typesPaperResearchpeer-review

TY - CONF

T1 - Young onset dementia: A scoping review of key pointers to diagnostic accuracy

AU - Parkes, Jacqueline

AU - Carter, Janet

AU - O'Malley, Mary

AU - Oyebode, Jan

AU - Stamou, Vasileios

AU - La Fontaine, Jenny

PY - 2019/6/4

Y1 - 2019/6/4

N2 - BackgroundRoutine psychiatric assessments tailored to older patients are often insufficient to identify the complexity of presentation in younger patients with dementia. Significant overlap between psychiatric disorders and neurodegenerative disease means that high rates of prior incorrect psychiatric diagnosis are common. Long delays to diagnosis, misdiagnosis and lack of knowledge from professionals are key concerns. No specific practice guidelines exist for diagnosis of young onset dementia (YOD). Aim The review evaluates the current evidence about best practice in diagnosis to guide thorough assessment of the complex presentations of YOD with a view to upskilling professionals in the field.Method A comprehensive search of the literature adopting a scoping review methodology was conducted regarding essential elements of diagnosis in YOD, over and above those in current diagnostic criteria for disease subtypes. This methodology was chosen because research in this area is sparse and not amenable to a traditional systematic review.Results The quality of evidence identified is variable with the majority provided from expert opinion and evidence is lacking on some topics. Evidence appears weighted towards diagnosis in fronto-temporal dementia (FTD) and its subtypes and young onset Alzheimer’s disease (AD). ConclusionThe literature demonstrates that a clinically rigorous and systematic approach is necessary in order to avoid mis- or under-diagnosis for younger people. The advent of new disease modifying treatments necessitates clinicians in the field to improve knowledge of new imaging techniques and genetics, with the goal of improving training and practice, and highlights the need for quality indicators and alignment of diagnostic procedures across clinical settings.

AB - BackgroundRoutine psychiatric assessments tailored to older patients are often insufficient to identify the complexity of presentation in younger patients with dementia. Significant overlap between psychiatric disorders and neurodegenerative disease means that high rates of prior incorrect psychiatric diagnosis are common. Long delays to diagnosis, misdiagnosis and lack of knowledge from professionals are key concerns. No specific practice guidelines exist for diagnosis of young onset dementia (YOD). Aim The review evaluates the current evidence about best practice in diagnosis to guide thorough assessment of the complex presentations of YOD with a view to upskilling professionals in the field.Method A comprehensive search of the literature adopting a scoping review methodology was conducted regarding essential elements of diagnosis in YOD, over and above those in current diagnostic criteria for disease subtypes. This methodology was chosen because research in this area is sparse and not amenable to a traditional systematic review.Results The quality of evidence identified is variable with the majority provided from expert opinion and evidence is lacking on some topics. Evidence appears weighted towards diagnosis in fronto-temporal dementia (FTD) and its subtypes and young onset Alzheimer’s disease (AD). ConclusionThe literature demonstrates that a clinically rigorous and systematic approach is necessary in order to avoid mis- or under-diagnosis for younger people. The advent of new disease modifying treatments necessitates clinicians in the field to improve knowledge of new imaging techniques and genetics, with the goal of improving training and practice, and highlights the need for quality indicators and alignment of diagnostic procedures across clinical settings.

KW - Young Onset Dementia

KW - Diagnostic accuracy

KW - Assessment

KW - Review

KW - Accuracy

UR - http://www.mendeley.com/research/youngonset-dementia-scoping-review-key-pointers-diagnostic-accuracy

U2 - 10.1192/bjo.2019.36

DO - 10.1192/bjo.2019.36

M3 - Paper

ER -