Mentally disordered offenders in prison: A tale of neglect?

Laura Knight, Mike Stephens

Research output: Contribution to Book/Report typesChapterResearchpeer-review

Abstract

Endothelial dysfunction underlies the pathogenesis of preeclampsia, but its mechanism has not yet been completely understood. Elevated oxygen free radicals may partially explain the endothelial cell damage. In this study, we have aimed to measure homocysteine (Hcy) and nitric oxide (NO) levels as endothelial dysfunction markers in preeclamptic women. Nineteen preeclamptic (33.9 +/- 1.4 weeks) and 15 gestational-age-matched normal pregnant women (35.5 +/- 0.7 weeks) were included in the study. Mean NO level was significantly lower (p <0.001) and mean Hcy level was significantly higher (p <0.001) in the preeclamptic group. Elevated Hcy and oxygen free radical levels could decrease NO levels due to the reaction with each other and reduced NO may increase blood pressure and ischemia in preeclamptic patients. We have concluded that increased Hcy and oxygen free radical levels, and decreased NO levels are closely associated with preeclampsia-related endothelial dysfunction.
Original languageEnglish
Title of host publicationInternet Journal of Criminology
Pages1-16
Number of pages16
DOIs
Publication statusPublished - 2009

Publication series

NameInternet Journal of Criminology

Fingerprint

Prisons
Homocysteine
Nitric Oxide
Free Radicals
Reactive Oxygen Species
Pre-Eclampsia
Gestational Age
Pregnant Women
Ischemia
Endothelial Cells
Blood Pressure

Cite this

Knight, L., & Stephens, M. (2009). Mentally disordered offenders in prison: A tale of neglect? In Internet Journal of Criminology (pp. 1-16). (Internet Journal of Criminology). https://doi.org/74824\r74824 [pii]
Knight, Laura ; Stephens, Mike. / Mentally disordered offenders in prison: A tale of neglect?. Internet Journal of Criminology. 2009. pp. 1-16 (Internet Journal of Criminology).
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abstract = "Endothelial dysfunction underlies the pathogenesis of preeclampsia, but its mechanism has not yet been completely understood. Elevated oxygen free radicals may partially explain the endothelial cell damage. In this study, we have aimed to measure homocysteine (Hcy) and nitric oxide (NO) levels as endothelial dysfunction markers in preeclamptic women. Nineteen preeclamptic (33.9 +/- 1.4 weeks) and 15 gestational-age-matched normal pregnant women (35.5 +/- 0.7 weeks) were included in the study. Mean NO level was significantly lower (p <0.001) and mean Hcy level was significantly higher (p <0.001) in the preeclamptic group. Elevated Hcy and oxygen free radical levels could decrease NO levels due to the reaction with each other and reduced NO may increase blood pressure and ischemia in preeclamptic patients. We have concluded that increased Hcy and oxygen free radical levels, and decreased NO levels are closely associated with preeclampsia-related endothelial dysfunction.",
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Knight, L & Stephens, M 2009, Mentally disordered offenders in prison: A tale of neglect? in Internet Journal of Criminology. Internet Journal of Criminology, pp. 1-16. https://doi.org/74824\r74824 [pii]

Mentally disordered offenders in prison: A tale of neglect? / Knight, Laura; Stephens, Mike.

Internet Journal of Criminology. 2009. p. 1-16 (Internet Journal of Criminology).

Research output: Contribution to Book/Report typesChapterResearchpeer-review

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T1 - Mentally disordered offenders in prison: A tale of neglect?

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AU - Stephens, Mike

PY - 2009

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AB - Endothelial dysfunction underlies the pathogenesis of preeclampsia, but its mechanism has not yet been completely understood. Elevated oxygen free radicals may partially explain the endothelial cell damage. In this study, we have aimed to measure homocysteine (Hcy) and nitric oxide (NO) levels as endothelial dysfunction markers in preeclamptic women. Nineteen preeclamptic (33.9 +/- 1.4 weeks) and 15 gestational-age-matched normal pregnant women (35.5 +/- 0.7 weeks) were included in the study. Mean NO level was significantly lower (p <0.001) and mean Hcy level was significantly higher (p <0.001) in the preeclamptic group. Elevated Hcy and oxygen free radical levels could decrease NO levels due to the reaction with each other and reduced NO may increase blood pressure and ischemia in preeclamptic patients. We have concluded that increased Hcy and oxygen free radical levels, and decreased NO levels are closely associated with preeclampsia-related endothelial dysfunction.

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M3 - Chapter

SN - 0378-7346 (Print)\r0378-7346 (Linking)

T3 - Internet Journal of Criminology

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BT - Internet Journal of Criminology

ER -

Knight L, Stephens M. Mentally disordered offenders in prison: A tale of neglect? In Internet Journal of Criminology. 2009. p. 1-16. (Internet Journal of Criminology). https://doi.org/74824\r74824 [pii]