Mentally disordered offenders in prison: A tale of neglect?

Laura Knight, Mike Stephens

Research output: Contribution to Book/ReportChapterpeer-review

Abstract

Endothelial dysfunction underlies the pathogenesis of preeclampsia, but its mechanism has not yet been completely understood. Elevated oxygen free radicals may partially explain the endothelial cell damage. In this study, we have aimed to measure homocysteine (Hcy) and nitric oxide (NO) levels as endothelial dysfunction markers in preeclamptic women. Nineteen preeclamptic (33.9 +/- 1.4 weeks) and 15 gestational-age-matched normal pregnant women (35.5 +/- 0.7 weeks) were included in the study. Mean NO level was significantly lower (p <0.001) and mean Hcy level was significantly higher (p <0.001) in the preeclamptic group. Elevated Hcy and oxygen free radical levels could decrease NO levels due to the reaction with each other and reduced NO may increase blood pressure and ischemia in preeclamptic patients. We have concluded that increased Hcy and oxygen free radical levels, and decreased NO levels are closely associated with preeclampsia-related endothelial dysfunction.
Original languageEnglish
Title of host publicationInternet Journal of Criminology
Pages1-16
Number of pages16
DOIs
Publication statusPublished - 2009

Publication series

NameInternet Journal of Criminology

Fingerprint Dive into the research topics of 'Mentally disordered offenders in prison: A tale of neglect?'. Together they form a unique fingerprint.

Cite this