The murine homologues of the huntington disease gene (Hdh) and the α-adducin gene (Add1) map to mouse chromosome 5 within a region of conserved synteny with human chromosome 4p16.3

Jamal Nasir, Biaoyang Lin, Maja Bucan, Tsutomu Koizumi, Joseph H. Nadeau, Michael R. Hayden

    Research output: Contribution to JournalArticle

    Abstract

    Huntington disease (HD) is a severe autosomal dominant neurodegenerative disorder associated with a novel gene (IT15). Recently, we reported the cloning of Hdh, the murine homologue of IT 15. Here, using an interspecific backcross, we have mapped both Hdh and the mouse homologue of human α-adducin (Add1), a membrane-associated cytoskeletal protein gene. Both of these genes map in the same position on mouse chromosome 5 in a region associated with ancestral chromosomal rearrangements and show no recombination with D5H4S43, D5H4S115, and D5H4S62, the murine homologues of D4S43, D4S115, and D4S62, respectively. Further mapping studies of humans, mice, and other mammalian species should reveal the nature of the rearrangements affecting this chromosomal segment during mammalian evolution. © 1994 Academic Press Inc.
    Original languageEnglish
    Pages (from-to)198-201
    Number of pages4
    JournalBMC Genomics
    Volume22
    Issue number1
    DOIs
    Publication statusPublished - 1 Jul 1994

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