Abnormal vibration-induced illusion of movement in idiopathic focal dystonia: An endophenotypic marker?

Nafsika Frima, Jamal Nasir, Richard A. Grünewald

    Research output: Contribution to journalArticleResearchpeer-review

    Abstract

    The frequency of symptomatic dystonia in relatives of patients with idiopathic focal dystonia (IFD) is higher than expected from epidemiologic studies implying that genetic factors may be involved. Perception of the vibration-induced illusion of movement (VIIM) is subnormal in patients with IFD compared with healthy volunteers and the abnormality corrects with volitional fatigue of the vibrated arm. The aim of the study was to establish the heritability of the abnormality of VIIM. The perception of illusion of movement elicited by vibration of the biceps brachii tendon before and after fatigue of the muscles was investigated in 30 patients with torticollis, 57 of their first degree relatives, and 19 healthy volunteers. VIIM did not change after fatigue in healthy controls. Before fatiguing the muscles, patients' perception of VIIM was less than healthy controls, (P <0.01, unpaired t-test). After fatigue, the illusion of movement perceived by patients increased, so that it did not differ any more from that of the healthy control subjects (P <0.05, repeated measures ANOVA). First degree relatives' response to vibration varied; 45% of parents, 60.7% of siblings, and 63.6% of children had an "abnormal" response to vibration compared with 21% of healthy volunteers. In contrast to patients' response, the "abnormality" did not correct after volitional fatigue of the vibrated arm. The results suggest that abnormal VIIM may represent an endophenotypic marker for IFD, which interacts with other factors including central motor learning and compensation mechanisms in the expression of the dystonic phenotype.
    Original languageEnglish
    Pages (from-to)373-377
    Number of pages5
    JournalMovement Disorders
    Volume23
    Issue number3
    DOIs
    Publication statusPublished - 15 Feb 2008

    Fingerprint

    Dystonic Disorders
    Vibration
    Fatigue
    Healthy Volunteers
    Torticollis
    Muscle Fatigue
    Dystonia
    Tendons
    Siblings
    Epidemiologic Studies
    Analysis of Variance
    Parents
    Learning
    Phenotype
    Muscles

    Keywords

    • Dystonia
    • Endophenotypic marker
    • Inheritance
    • Vibration-induced illusion of movement

    Cite this

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    title = "Abnormal vibration-induced illusion of movement in idiopathic focal dystonia: An endophenotypic marker?",
    abstract = "The frequency of symptomatic dystonia in relatives of patients with idiopathic focal dystonia (IFD) is higher than expected from epidemiologic studies implying that genetic factors may be involved. Perception of the vibration-induced illusion of movement (VIIM) is subnormal in patients with IFD compared with healthy volunteers and the abnormality corrects with volitional fatigue of the vibrated arm. The aim of the study was to establish the heritability of the abnormality of VIIM. The perception of illusion of movement elicited by vibration of the biceps brachii tendon before and after fatigue of the muscles was investigated in 30 patients with torticollis, 57 of their first degree relatives, and 19 healthy volunteers. VIIM did not change after fatigue in healthy controls. Before fatiguing the muscles, patients' perception of VIIM was less than healthy controls, (P <0.01, unpaired t-test). After fatigue, the illusion of movement perceived by patients increased, so that it did not differ any more from that of the healthy control subjects (P <0.05, repeated measures ANOVA). First degree relatives' response to vibration varied; 45{\%} of parents, 60.7{\%} of siblings, and 63.6{\%} of children had an {"}abnormal{"} response to vibration compared with 21{\%} of healthy volunteers. In contrast to patients' response, the {"}abnormality{"} did not correct after volitional fatigue of the vibrated arm. The results suggest that abnormal VIIM may represent an endophenotypic marker for IFD, which interacts with other factors including central motor learning and compensation mechanisms in the expression of the dystonic phenotype.",
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    doi = "10.1002/mds.21838",
    language = "English",
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    Abnormal vibration-induced illusion of movement in idiopathic focal dystonia: An endophenotypic marker? / Frima, Nafsika; Nasir, Jamal; Grünewald, Richard A.

    In: Movement Disorders, Vol. 23, No. 3, 15.02.2008, p. 373-377.

    Research output: Contribution to journalArticleResearchpeer-review

    TY - JOUR

    T1 - Abnormal vibration-induced illusion of movement in idiopathic focal dystonia: An endophenotypic marker?

    AU - Frima, Nafsika

    AU - Nasir, Jamal

    AU - Grünewald, Richard A.

    PY - 2008/2/15

    Y1 - 2008/2/15

    N2 - The frequency of symptomatic dystonia in relatives of patients with idiopathic focal dystonia (IFD) is higher than expected from epidemiologic studies implying that genetic factors may be involved. Perception of the vibration-induced illusion of movement (VIIM) is subnormal in patients with IFD compared with healthy volunteers and the abnormality corrects with volitional fatigue of the vibrated arm. The aim of the study was to establish the heritability of the abnormality of VIIM. The perception of illusion of movement elicited by vibration of the biceps brachii tendon before and after fatigue of the muscles was investigated in 30 patients with torticollis, 57 of their first degree relatives, and 19 healthy volunteers. VIIM did not change after fatigue in healthy controls. Before fatiguing the muscles, patients' perception of VIIM was less than healthy controls, (P <0.01, unpaired t-test). After fatigue, the illusion of movement perceived by patients increased, so that it did not differ any more from that of the healthy control subjects (P <0.05, repeated measures ANOVA). First degree relatives' response to vibration varied; 45% of parents, 60.7% of siblings, and 63.6% of children had an "abnormal" response to vibration compared with 21% of healthy volunteers. In contrast to patients' response, the "abnormality" did not correct after volitional fatigue of the vibrated arm. The results suggest that abnormal VIIM may represent an endophenotypic marker for IFD, which interacts with other factors including central motor learning and compensation mechanisms in the expression of the dystonic phenotype.

    AB - The frequency of symptomatic dystonia in relatives of patients with idiopathic focal dystonia (IFD) is higher than expected from epidemiologic studies implying that genetic factors may be involved. Perception of the vibration-induced illusion of movement (VIIM) is subnormal in patients with IFD compared with healthy volunteers and the abnormality corrects with volitional fatigue of the vibrated arm. The aim of the study was to establish the heritability of the abnormality of VIIM. The perception of illusion of movement elicited by vibration of the biceps brachii tendon before and after fatigue of the muscles was investigated in 30 patients with torticollis, 57 of their first degree relatives, and 19 healthy volunteers. VIIM did not change after fatigue in healthy controls. Before fatiguing the muscles, patients' perception of VIIM was less than healthy controls, (P <0.01, unpaired t-test). After fatigue, the illusion of movement perceived by patients increased, so that it did not differ any more from that of the healthy control subjects (P <0.05, repeated measures ANOVA). First degree relatives' response to vibration varied; 45% of parents, 60.7% of siblings, and 63.6% of children had an "abnormal" response to vibration compared with 21% of healthy volunteers. In contrast to patients' response, the "abnormality" did not correct after volitional fatigue of the vibrated arm. The results suggest that abnormal VIIM may represent an endophenotypic marker for IFD, which interacts with other factors including central motor learning and compensation mechanisms in the expression of the dystonic phenotype.

    KW - Dystonia

    KW - Endophenotypic marker

    KW - Inheritance

    KW - Vibration-induced illusion of movement

    UR - http://www.mendeley.com/research/abnormal-vibrationinduced-illusion-movement-idiopathic-focal-dystonia-endophenotypic-marker

    U2 - 10.1002/mds.21838

    DO - 10.1002/mds.21838

    M3 - Article

    VL - 23

    SP - 373

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    JO - Movement Disorders

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    ER -