Centre for Physical Activity and Life Sciences

Organization profile

Organisation profile

The Centre focuses on physiological, psychological and biomechanical aspects of physical activity interventions in sedentary, active and clinical populations, and the microbiological, genetic and molecular aspects of disease progression to target national and global challenges to health.

The Research Centre aims to:

  • Bring together researchers examining physiological, psychological and biomechanical aspects of physical activity interventions in sedentary, active and clinical populations, and the microbiological, genetic and molecular aspects of disease progression.
  • Develop research capacity by providing training for undergraduate to postdoctoral researchers and supporting early career researchers to become independent research leaders targeting national and global challenges to health.

The Centre for Physical Activity and Life Sciences is a multidisciplinary Centre including expertise in Biosciences, Sport & Exercise Sciences, Podiatry, and Occupational Therapy.  The Centre includes two main Research Groups (Molecular Biosciences Research Group, Neuromuscular and Musculoskeletal Research Group) with the main interests of researchers in these Groups outlined below:

  • Molecular Biosciences Research Group
    • Immunogenetics
    • Clinical genetics and genomics
    • RNA-based gene therapy
    • Cancer biology
    • Neuromuscular and neurodegenerative disorders
    • Monozygotic twin studies
    • Bioethics
    • Antimicrobial resistance
    • Molecular Mechanisms of Bacterial Pathogenesis
    • Infection control
  • Neuromuscular and Musculoskeletal Research Group
    • Functional decline during ageing and fall risk
    • Sarcopenia and osteoporosis
    • Eccentric exercise in healthy and ageing populations
    • Cognitive impairment, pain and balance in ageing
    • Muscle stretching techniques and strain injury
    • Isometric resistance training and hypertension
    • Exercise-induced muscle damage
    • Heat- and cryo-based therapy
    • Stroke rehabilitation
    • Concussion in impact sports

Fingerprint Dive into the research topics where Centre for Physical Activity and Life Sciences is active. These topic labels come from the works of this organisation's members. Together they form a unique fingerprint.

Muscles Medicine & Life Sciences
Duchenne Muscular Dystrophy Medicine & Life Sciences
Articular Range of Motion Medicine & Life Sciences
Dystrophin Medicine & Life Sciences
Muscle Stretching Exercises Medicine & Life Sciences
Exons Medicine & Life Sciences
Exercise Medicine & Life Sciences
Tendons Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects 2018 2018

RDS EM Public Involvement Fund

Kay, T.

National Institute for Health Research (NIHR)

1/10/181/11/18

Project: EnterpriseConsultancy Charity

Research Output 2003 2019

A mutation in the major autophagy gene, WIPI2, associated with global developmental abnormalities

Nasir, J., 10 Apr 2019, In : Brain. 142, 5, p. 1242-1254 13 p.

Research output: Contribution to JournalArticle

Open Access
Autophagy
Phosphatidylinositols
Mutation
Pedigree
Genes

Arterial stiffness is a predictor for acute kidney injury following coronary artery bypass graft surgery

Greenwood, S. A., Mangahis, E., Castle, E. M., Wang, J., Campbell, J., Deshpande, R. & Jayawardene, S., 7 Mar 2019, In : Journal of Cardiothoracic Surgery. 14, 1, p. 51 5 p.

Research output: Contribution to JournalArticle

Open Access
File
Vascular Stiffness
Acute Kidney Injury
Coronary Artery Bypass
Thoracic Surgery
Transplants

De novo single-nucleotide and copy number variation in discordant monozygotic twins reveals disease-related genes

Vadgama, N., Pittman, A., Simpson, M., Nirmalananthan, N., Murray, R., Yoshikawa, T., De Rijk, P., Rees, E., Kirov, G., Hughes, D., Fitzgerald, T., Kristiansen, M., Pearce, K., Cerveira, E., Zhu, Q., Zhang, C., Lee, C., Hardy, J. & Nasir, J., 18 Mar 2019, In : European journal of human genetics : EJHG. 27, p. 1121-1133 13 p.

Research output: Contribution to JournalArticle

Open Access
File
Monozygotic Twins
Nucleotides
Genes
Amyotrophic Lateral Sclerosis
Schizotypal Personality Disorder

Activities 2007 2019

Access Microbiology (Journal)

Alexandra Woodacre (Reviewer)
25 Mar 2019

Activity: Publication Peer-review and Editorial WorkPublication Peer-reviewResearch

Induction of inflammasome-dependent signalling in the human monocytic cell line THP-1 by Campylobacter lipooligosaccharides

Alexandra Woodacre (Speaker)
11 Apr 2019

Activity: Academic Talks or PresentationsOral presentationResearch

Feeding the nation's dogs: best friends and diet fads

Wanda McCormick (Speaker)
17 Sep 2019

Activity: Academic Talks or PresentationsOral presentationResearch

File

Impacts

FDA approves first drug to treat Duchenne muscular dystrophy (DMD)

Karen Anthony (Co-Investigator)

Impact: Public policy impacts, Health and Well-Being impacts, Quality of life impacts, 03: Good Health and Well-Being (UN SDG)

Student theses

Characterisation of the Lipooligosaccharide biosynthesis gene cluster in Campylobacter species.

Author: Hameed, A., 30 Oct 2019

Supervisor: Machado, L. (Supervisor), Marsden, G. L. (External person) (Supervisor) & Woodacre, A. (Supervisor)

Student thesis: Doctoral Thesis