Centre for Physical Activity and Life Sciences

Research Output 2003 2019

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2019

A mutation in the major autophagy gene, WIPI2, associated with global developmental abnormalities

Nasir, J., 10 Apr 2019, In : Brain. 142, 5, p. 1242-1254 13 p.

Research output: Contribution to JournalArticle

Open Access
Autophagy
Phosphatidylinositols
Mutation
Pedigree
Genes

Arterial stiffness is a predictor for acute kidney injury following coronary artery bypass graft surgery

Greenwood, S. A., Mangahis, E., Castle, E. M., Wang, J., Campbell, J., Deshpande, R. & Jayawardene, S., 7 Mar 2019, In : Journal of Cardiothoracic Surgery. 14, 1, p. 51 5 p.

Research output: Contribution to JournalArticle

Open Access
File
Vascular Stiffness
Acute Kidney Injury
Coronary Artery Bypass
Thoracic Surgery
Transplants

De novo single-nucleotide and copy number variation in discordant monozygotic twins reveals disease-related genes

Vadgama, N., Pittman, A., Simpson, M., Nirmalananthan, N., Murray, R., Yoshikawa, T., De Rijk, P., Rees, E., Kirov, G., Hughes, D., Fitzgerald, T., Kristiansen, M., Pearce, K., Cerveira, E., Zhu, Q., Zhang, C., Lee, C., Hardy, J. & Nasir, J., 18 Mar 2019, In : European journal of human genetics : EJHG. 27, p. 1121-1133 13 p.

Research output: Contribution to JournalArticle

Open Access
File
Monozygotic Twins
Nucleotides
Genes
Amyotrophic Lateral Sclerosis
Schizotypal Personality Disorder

Distinct proteomic profiles in monozygotic twins discordant for ischaemic stroke

Vadgama, N., Lamont, D., Hardy, J., Nasir, J. & Lovering, R. C., 15 Jun 2019, In : Molecular and Cellular Biochemistry. 456, 1-2, p. 157-165 9 p.

Research output: Contribution to JournalArticle

Monozygotic Twins
Proteomics
Stroke
Gene Ontology
Atopic Dermatitis

Dystrophin Dp71 and the Neuropathophysiology of Duchenne Muscular Dystrophy

Naidoo, M. & Anthony, K., 13 Dec 2019, In : Molecular Neurobiology. p. 1-20 21 p.

Research output: Contribution to JournalArticle

Open Access
Dystrophin
Duchenne Muscular Dystrophy
Brain
Muscle
Genes

Estimating actual foot size from a static bare foot print in a White British Population

Curran, M. J., Campbell, J. A., Gillespie, L., Melville, S. & Kagan, B., 21 Jan 2019, In : Science & Justice. 59, p. 317-321 5 p.

Research output: Contribution to JournalArticle

Open Access
File
regression
intelligence
offense
evidence
student

Influence of Habitual Physical Behavior – Sleeping, Sedentarism, Physical Activity – On Bone Health in Community-Dwelling Older People

Degens, H., Doody, C., Wullems, J., Ryan, D. J., Morse, C. & Onambele-Pearson, G., 15 Apr 2019, In : Frontiers in Physiology. 10, 408, p. 1-15 15 p., 408.

Research output: Contribution to JournalArticle

Open Access
File
Independent Living
Bone Density
Exercise
Bone and Bones
Health
Cell death
N-Methylaspartate
N-Methyl-D-Aspartate Receptors
Dopamine
Cell Death

Perception of the ethical acceptability of live prey feeding to aquatic species kept in captivity.

Marshall, L., McCormick, W. & Cooke, G., 22 Aug 2019, In : PLoS ONE. 14, 8, p. 1-17 17 p.

Research output: Contribution to JournalArticle

Open Access
File
Animals
aquariums
animals
zoos
Zoo Animals
Open Access
File
Sleep
Lipoprotein Lipase
Glycosylated Hemoglobin A
Glucose
Interleukin-6

The effect of isokinetic dynamometer deceleration phase on maximum ankle joint range of motion and plantar flexor mechanical properties tested at different angular velocities

Pinto, M., Wilson, C., Kay, A. D., Cochrane, J. & Blazevich, A. J., 19 Jul 2019, In : Journal of Biomechanics. 92, p. 169-174 6 p.

Research output: Contribution to JournalArticle

ROM
Ankle Joint
Deceleration
Dynamometers
Angular velocity

The External Validity of a Novel Contract-Relax Stretching Technique on Knee Flexor Range of Motion

Kay, A. D., Dixon, J., Bligh, L. D. & Blazevich, A. J., 23 Sep 2019, In : Scandinavian Journal Of Medicine & Science in Sports. 30, 1, p. 74-82 9 p.

Research output: Contribution to JournalArticle

Open Access
Contracts
Articular Range of Motion
Knee
Activities of Daily Living
Prescriptions

Using isotemporal substitution to predict the effects of changing physical behaviour on older adults’ cardio-metabolic profiles

Ryan, D., Wullems, J., Stebbings, G., Morse, C., Stewart, C. & Onambele-Pearson, G., 23 Oct 2019, In : PLoS ONE. 14, 10, p. 1-14

Research output: Contribution to JournalArticle

Open Access
File
Metabolome
Triglycerides
Substitution reactions
Procollagen
Lipoprotein Lipase

Variable, but not free-weight, resistance back squat exercise potentiates jump performance following a comprehensive task-specific warm-up

Mina, M. A., Blazevich, A. J., Tsatalas, T., Giakas, G., Seitz, L. B. & Kay, A. D., 1 Mar 2019, In : Scandinavian Journal of Medicine & Science in Sports. 29, 3, p. 380-392 13 p.

Research output: Contribution to JournalArticle

Open Access
File
Quadriceps Muscle
Electromyography
Exercise
Weights and Measures
Warm-Up Exercise
2018

Acute response to a 2-minute isometric exercise test predicts the blood pressure lowering efficacy of isometric resistance training in young adults

Baross, A., Somani, Y., Milne, K., McGowan, C. & Swaine, I. L., 1 Mar 2018, In : American Journal of Hypertention . 31, 3, p. 362–368 7 p.

Research output: Contribution to JournalArticle

Open Access
Resistance Training
Exercise Test
Young Adult
Exercise
Blood Pressure

A missense mutation in TRAPPC6A leads to build-up of the protein, in patients with a neurodevelopmental syndrome and dysmorphic features

Mohamoud, H. S., Ahmed, S., Jelani, M., Alrayes, N., Childs, K., Vadgama, N., Almramhi, M. M., Al-Aama, J. Y., Goodbourn, S. & Nasir, J., 1 Dec 2018, In : Scientific Reports. 8, 1, 2053.

Research output: Contribution to JournalArticle

Open Access
File
Missense Mutation
Intellectual Disability
Polydactyly
Exome
Language Development Disorders

A multicenter comparison of quantification methods for antisense oligonucleotide-induced DMD exon 51 skipping in Duchenne muscular dystrophy cell cultures

Hiller, M., Falzarano, M. S., Garcia-Jimenez, I., Sardone, V., Verheul, R. C., Popplewell, L., Anthony, K., Ruiz-Del-Yerro, E., Osman, H., Goeman, J. J., Mamchaoui, K., Dickson, G., Ferlini, A., Muntoni, F., Aartsma-Rus, A., Arechavala-Gomeza, V., Datson, N. A. & Spitali, P., 2 Oct 2018, In : PLoS ONE. 13, 10, p. 1-15 15 p.

Research output: Contribution to JournalArticle

Open Access
File
Duchenne Muscular Dystrophy
Antisense Oligonucleotides
Exons
Cell Culture Techniques
Polymerase Chain Reaction

A survey of rabbit handling methods within the United Kingdom and the Republic of Ireland

Oxley, J. A., Ellis, C., McBride, E. A. & McCormick, W. D., 25 Apr 2018, In : Journal of Applied Animal Welfare Science. p. 1-12 12 p.

Research output: Contribution to JournalArticle

Open Access
File
Ireland
Rabbits
Pets
Laboratory Personnel
Animal Hospitals
Open Access
File
Macropus parma
zoos
foraging
urination
agonistic behavior

Cardiorespiratory and perceptual responses to self-regulated and imposed submaximal arm-leg ergometry

Hill, M., Talbot, C. & Puddiford, M., 1 May 2018, In : European Journal of Applied Physiology. 118, 5, p. 1011-1019 9 p.

Research output: Contribution to JournalArticle

Ergometry
Leg
Arm
Heart Rate
Pulmonary Ventilation

Changes in postural sway and gait characteristics as a consequence of anterior load carriage

Roberts, M., Talbot, C., Kay, A. D., Price, M. & Hill, M., 1 Oct 2018, In : Gait & Posture. 66, p. 139-145 7 p.

Research output: Contribution to JournalArticle

Open Access
File
Gait
Pressure
Walking
Weights and Measures
Wounds and Injuries

Details of canine hydrotherapy pools and treadmills in 22 hydrotherapy centres in the United Kingdom

McCormick, W., Oxley, J. A. & Spencer, N., 28 Jul 2018, In : Veterinary Record. 183, 4, p. 128-129 2 p.

Research output: Contribution to JournalArticle

Open Access
File
Physical therapy
Exercise equipment
Industry

Effects of external loads on postural sway during quiet stance in adults aged 20–80 years

Hill, M. W., Duncan, M. J., Oxford, S. W., Kay, A. D. & Price, M. J., 1 Jan 2018, In : Applied Ergonomics. 66, p. 64-69 6 p.

Research output: Contribution to JournalArticle

Open Access
File
Hand
Pressure
Activities of Daily Living
Age Groups

No Effect of Muscle Stretching within a Full, Dynamic Warm-up on Athletic Performance

Blazevich, A. J., Gill, N. D., Kvorning, T., Kay, A. D., Goh, A. M., Hilton, B., Drinkwater, E. J. & Behm, D. G., 1 Jun 2018, In : Medicine & Science in Sports & Exercise. 50, 6, p. 1258-1266 9 p., 6.

Research output: Contribution to JournalArticle

Open Access
File
Muscle Stretching Exercises
Athletic Performance
Running
Muscles
Athletes
Open Access
File
Primary Health Care
General Practitioners
Control Groups
Neoplasms
General Practice

Reliability and validity of the international physical activity questionnaire compared to calibrated accelerometer cut-off points in the quantification of sedentary behaviour and physical activity in older-old adults.

Ryan, D. J., Wullems, J., Stebbings, G., Morse, C., Stewart, C. & Onambele-Pearson, G., 19 Apr 2018, In : PLoS ONE. 13, 4, p. 1-17 17 p.

Research output: Contribution to JournalArticle

Open Access
File
Reproducibility of Results
Sex Characteristics
Thigh
Surveys and Questionnaires

Segregating the distinct effects of sedentary behaviour and physical activity on older adults’ cardiovascular profile: Part 1- Regression model approach.

Ryan, D. J., Wullems, J., Stebbings, G., Morse, C., Stewart, C. & Onambele-Pearson, G., 1 Jul 2018, In : Journal of Physical Activity and Health. 15, 7, p. 499-509 11 p.

Research output: Contribution to JournalArticle

Open Access
File
Light
Popliteal Artery
Brachial Artery
Insurance Benefits
Thigh

Segregating the distinct effects of sedentary behaviour and physical activity on older adults’ cardiovascular profile: Part 2- Isotemporal substitution approach.

Ryan, D. J., Wullems, J., Stebbings, G., Morse, C., Stewart, C. & Onambele-Pearson, G., 1 Jul 2018, In : Journal of Physical Activity and Health. 15, 7, p. 537-542 6 p., 7.

Research output: Contribution to JournalArticle

Open Access
File
Popliteal Artery
Carotid Arteries
Brachial Artery
Thigh
Life Style

Stretch imposed on active muscle elicits positive adaptations in strain risk factors and exercise-induced muscle damage

Kay, A. D., Rubley, B., Talbot, C., Mina, M. A., Baross, A. W. & Blazevich, A. J., 1 Nov 2018, In : Scandinavian Journal Of Medicine & Science in Sports. 28, 11, p. 2299–2309 11 p.

Research output: Contribution to JournalArticle

Open Access
File
Exercise
Muscles
Myalgia
Knee
Creatine Kinase

Targeting gp100 and TRP-2 with a DNA vaccine: incorporating T cell epitopes with a human IgG1 antibody induces potent T cell responses that are associated with favourable clinical outcome in a phase I/II trial

Patel, P. M., Ottensmeier, C., Mulatero, C., Lorigan, P., Plummer, R., Pandha, H., Elsheik, S., Hadjimichael, E., Villasanti, N., Adams, S. E., Cunnell, M., Metheringham, R. L., Brentville, V. A., Machado, L., Daniels, I., Gijon, M., Hannaman, D. & Durrant, L. G., 2018, In : OncoImmunology. 7, 6, p. e1433516

Research output: Contribution to JournalArticle

Open Access
File
DNA Vaccines
T-Lymphocyte Epitopes
Immunoglobulin G
T-Lymphocytes
Antibodies
2017

Ageing, urban environments and place: moving towards a transdisciplinary research agenda

Woolrych, R. & Sixsmith, J., 25 Feb 2017, In : Bulletin of People-Environmental Studies. 44

Research output: Contribution to JournalArticle

Open Access
File

Ageing well in the right place: partnership working with older people

Sixsmith, J., Fang, M. L., Woolrych, R., Canham, S., Battersby, L. & Sixsmith, A., 25 Jan 2017, In : Working with Older People. 21, 1

Research output: Contribution to JournalArticle

Open Access
File
housing
service provider
community
decision making process
expertise

Analysis of Factors Relating to Companion Rabbits Relinquished to Two United Kingdom Rehoming Centers

Ellis, C. F., McCormick, W. & Tinarwo, A., 21 Apr 2017, In : Journal of Applied Animal Welfare Science. 20, 3, p. 230-239 10 p.

Research output: Contribution to JournalArticle

Open Access
File
Statistical Factor Analysis
Rabbits
United Kingdom
Ownership
Pets
Open Access
File
Singing
Learning Disorders
Dementia
Brain
Communication

A UV cross-linking method combined with infrared imaging to analyse RNA–protein interactions

Malmqvist, T., Spickett, C., Gallo, J-M. & Anthony, K., 5 Jun 2017, In : Biology Methods & Protocols. 2, 1, p. 1-4 4 p., 1.

Research output: Contribution to JournalArticle

Open Access
File
Infrared imaging
Labeling
RNA
Untranslated Regions
RNA Probes

Development of a cancer risk prediction tool for use in the UK Primary Care and community settings

Lophatananon, A., Usher-Smith, J., Campbell, J., Warcaba, J., Silarova, B., Waters, E. A., Colditz, G. A. & Muir, K. R., 1 Jul 2017, In : Cancer Prevention Research. 10, 7

Research output: Contribution to JournalArticle

Open Access
File
Primary Health Care
Neoplasms
Population
Life Style
Equidae

From familiar faces to family: staff and resident relationships in long-term care

Canham, S. L., Battersby, L., Fang, M. L., Sixsmith, J., Woolrych, R. & Sixsmith, A., 1 Aug 2017, In : Journal of Aging and Health. 29, 5

Research output: Contribution to JournalArticle

resident
staff
second home
evidence
experience

Health and wellbeing amongst older people research in Northamptonshire

Poole, H., Sixsmith, J., Parkes, J., Ward, A., Pyer, M., Campbell, J., Machado, L., Rehling, T., Youell, J., Carter, J., Oyebode, J., O’Malley, M., Anthony, K., Rogers, S., Jones, J., Siddons, L., Smith, L-A., Kay, T., Fraser, M., Score, J. & 8 others, El Khoury, L., Hameed, A., Albalbeisi, N., Durrant, L. G., Al-Zubaidi, R., Al-Rayahi, I., da Silva, K. & Taylor, J., 1 Aug 2017, In : East Midlands Research into Ageing Network (EMRAN) Discussion Paper Series. 15

Research output: Contribution to JournalArticle

Open Access
File
health
research practice
commitment
Values

High mobility group protein B1 is a predictor of poor survival in ovarian cancer

Machado, L., Moseley, P. M., Moss, R., Deen, S., Nolan, C., Spendlove, I. & Ramage, J., 24 Nov 2017, In : Oncotarget. 8, 60

Research output: Contribution to JournalArticle

Open Access
File
High Mobility Group Proteins
Ovarian Neoplasms
Survival
Neoplasms
Kaplan-Meier Estimate

Incorporating cancer risk information into general practice: a qualitative study using focus groups with healthcare professionals

Usher-Smith, J., Silarova, B., Ward, A., Youell, J., Muir, K., Campbell, J. & Warcaba, J., 23 Feb 2017, In : British Journal of General Practice. 67, 656

Research output: Contribution to JournalArticle

Open Access
File
Focus Groups
General Practice
Delivery of Health Care
Life Style
Neoplasms

Individualising the exposure of −110°C whole body cryotherapy: the effects of sex and body composition

Cuttell, S., Hammond, L., Langdon, D. & Costello, J., 27 Jan 2017, In : Journal of Thermal Biology. 65

Research output: Contribution to JournalArticle

Open Access
File
Cryotherapy
Body Composition
Skin Temperature
Thigh
Sex Characteristics

Population genetics of immune-related multilocus CNV in Native Americans

Zuccherato, L., Schneider, S., Tarazona-Santos, E., Hardwick, R. J., Berg, D., Bogle, H., Gouveia, M., Machado, L., Machado, M., Rodrigues-Soares, F., Soares-Souza, G., Togni, D., Zamudio, R., Gilman, R., Duarte, D., Hollox, E. J. & Rodrigues, M. R., 29 Mar 2017, In : Journal of the Royal Society Interface. 14, 128

Research output: Contribution to JournalArticle

Open Access
File
American Indians
population genetics
loci
population structure
assortative mating

Reductions in ambulatory blood pressure in young normotensive men and women after isometric resistance training and its relationship with cardiovascular reactivity

Somani, Y., Baross, A. W., Levy, P., Zinszer, K., Milne, K., Swaine, I. & McGowan, C., 1 Feb 2017, In : Blood Pressure Monitoring. 22, 1, p. 1-7 7 p.

Research output: Contribution to JournalArticle

Open Access
File
Resistance Training
Blood Pressure
Primary Prevention
Hypertension
Isometric Contraction

Reductions in resting blood pressure in young adults when isometric exercise is performed whilst walking

Baross, A. W., Hodgson, D. A., Padfield, S. L. & Swaine, I. L., 7 May 2017, In : Journal of Sports Medicine. 2017, p. 1-6 6 p., 7123834.

Research output: Contribution to JournalArticle

Open Access
Walking
Young Adult
Exercise
Blood Pressure
Arterial Pressure

Responses to provision of personalised cancer risk information: a qualitative interview study with members of the public

Usher-Smith, J. A., Silarova, B., Lophatananon, A., Duschinsky, R., Campbell, J., Warcaba, J. & Muir, K., 22 Dec 2017, In : BMC Public Health. 17, 1

Research output: Contribution to JournalArticle

Open Access
File
Interviews
Neoplasms
Health Behavior
Risk Reduction Behavior
Life Style
2016

A comparison of 2 practical cooling methods on cycling capacity in the heat

Cuttell, S. & Tyler, C. P., 1 Jul 2016, In : Journal of athletic training. 51, 7, p. 525-532 8 p.

Research output: Contribution to JournalArticle

Open Access
Torso
Neck
Hot Temperature
Skin Temperature
Temperature

Acute effects of contract-relax (CR) stretch versus a modified CR technique

Kay, A. D., Dods, S. & Blazevich, A. J., 1 Mar 2016, In : European Journal of Applied Physiology. 116, 3, p. 611-621 11 p.

Research output: Contribution to JournalArticle

Open Access
File
Contracts
Articular Range of Motion
Sports
Muscles
Achilles Tendon

Aging gracefully across environments using technology to support wellness, engagement and long life (AGE-WELL): a national research network in technology and aging

Sixsmith, A., Mihailidis, A., Sixsmith, J., Fang, M. L. & Battersby, L., 28 Sep 2016, In : Gerontechnology. 15, supp

Research output: Contribution to JournalArticle

Open Access
File

A knowledge synthesis of culturally- and spiritually-sensitive end-of-life care: findings from a scoping review

Fang, M. L., Sixsmith, J., Sinclair, S. & Horst, G., 18 May 2016, In : BMC Geriatrics. 16, 107, p. 1-14 14 p.

Research output: Contribution to JournalArticle

Open Access
File
Terminal Care
Decision Making
Hospices
Communication Barriers
Literature

Chain-loaded variable resistance warm-up improves free-weight maximal back squat performance

Mina, M. A., Blazevich, A. J., Giannis, G., Seitz, L. B. & Kay, A. D., 1 Nov 2016, In : European Journal of Sport Science. 16, 8, p. 932-939 8 p.

Research output: Contribution to JournalArticle

Open Access
File
Knee
Weights and Measures
Electromyography
Knee Joint
Mechanics