Centre for Physical Activity and Life Sciences

Research Output 2003 2019

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Abstract
2019

Effects of Isometric Resistance Training and Detraining on Ambulatory Blood Pressure and Morning Blood Pressure Surge in Young Normotensives

Baross, A., McGowan, C., Jay, G., Stoodley, L. & Swaine, I. L., 6 Jul 2019, p. 1.

Research output: Contribution to ConferenceAbstract

Resistance Training
Blood Pressure

Effects of seated isokinetic eccentric training and detraining on mobility, balance, strength, muscle size and architecture in older adults

Kay, A. D., Ashmore, L., Hill, M., Mina, M. A. & Blazevich, A. J., 4 Jul 2019.

Research output: Contribution to ConferenceAbstract

Muscle Strength
Postural Balance
Ankle
Education
Lower Extremity

The effects of stretching rate on plantar flexor neuromechanical properties and maximum ankle range of motion

Pinto, M., Wilson, C. J., Kay, A. D. & Blazevich, A. J., 6 Jul 2019.

Research output: Contribution to ConferenceAbstract

Articular Range of Motion
Ankle
Joints
Electromyography
Athletic Performance

Variable, but not free-weight, loaded countermovement jump exercise potentiates jump performance following a comprehensive task-specific warm-up

Mina, M. A., Blazevich, A. J., Tsatalas, T., Giles, D., Kalotyhos, S., Giakas, G., Hooton, A. & Kay, A. D., 14 Mar 2019, (Accepted/In press).

Research output: Contribution to ConferenceAbstract

Exercise
Weights and Measures
Quadriceps Muscle
Electromyography
Muscles
2018

Changes in postural sway and gait characteristics as a consequence of anterior load carriage

Hill, M., Roberts, M., Talbot, C., Kay, A. D. & Price, M., 4 Jul 2018.

Research output: Contribution to ConferenceAbstract

Open Access
File
Gait
Pressure
Walking
Weights and Measures
Research

Effects of unilateral isokinetic eccentric training (and detraining) on musculoskeletal characteristics in older people

Kay, A. D., Fraser, M., Hill, M. & Blazevich, A. J., 5 Jul 2018.

Research output: Contribution to ConferenceAbstract

Open Access
File
Lower Extremity
Quadriceps Muscle
Muscle Strength
Education
Exercise Tolerance

High fat diet induced obesity modulates melanoma tumour microenvironment in low density lipoprotein receptor deficient LDLR-/- mouse model.

Al-Zubaidi, R., Stover, C. & Machado, L. R., 13 Sep 2018, p. 90. 1 p.

Research output: Contribution to ConferenceAbstract

Open Access
Tumor Microenvironment
LDL Receptors
High Fat Diet
Melanoma
Obesity
Open Access
File
Dystrophin
Duchenne Muscular Dystrophy
Cell Movement
Protein Isoforms
Cell Proliferation
2017

Abstract 9035: An adjuvant clinical trial of SCIB1, a DNA vaccine that targets dendritic cells in vivo, in fully resected melanoma patients

Patel, P. M., Ottensmeier, C., Mulatero, C., Lorigan, P., Plummer, R., Hannaman, D., Cunnell, M., Metheringham, R. L., Brentville, V. A., Daniels, I., Machado, L. & Durrant, L. G., 31 Jan 2017.

Research output: Contribution to ConferenceAbstract

DNA Vaccines
Dendritic Cells
Melanoma
Clinical Trials
Epitopes

Brain involvement in Duchenne muscular dystrophy: a role for dystrophin isoform Dp71 in cell migration and proliferation

Ash, A., Booth-Wynne, L. & Anthony, K., 2 Oct 2017, In : Neuromuscular Disorders. 27, Supp 2

Research output: Contribution to JournalAbstract

Open Access
File
Dystrophin
Duchenne Muscular Dystrophy
Cell Movement
Protein Isoforms
Cell Proliferation

Effects of Isometric leg Training on Ambulatory Blood pressure and Morning Blood pressure Surge in Young Normotensive Men and Women

Baross, A., Milne, K., McGowan, C. & Swaine, I. L., 8 Sep 2017, p. 1.

Research output: Contribution to ConferenceAbstract

Leg
Blood Pressure
Resistance Training
Cardiovascular Diseases
Atherosclerotic Plaques

Stretching of active muscle evokes greater acute increases in plantarflexor range of motion than static stretching

Kay, A. D., Khan, S., Baross, A. W. & Blazevich, A. J., 7 Jul 2017.

Research output: Contribution to ConferenceAbstract

Open Access
File
Muscle Stretching Exercises
Articular Range of Motion
Muscles
Achilles Tendon
Cross-Over Studies
Open Access
File
Muscle Stretching Exercises
Articular Range of Motion
Muscles
Tendons
Muscle Tonus

The acute effects of free-weight and elastic band back squat exercise on subsequent vertical jump performance

Mina, M. A., Blazevich, A. J., Tsatalas, T., Giakas, G., Seitz, L. B., Hooton, A. & Kay, A. D., 7 Jul 2017.

Research output: Contribution to ConferenceAbstract

Open Access
File
Exercise
Weights and Measures
Electromyography
Quadriceps Muscle
Athletes
2016

Acute effects of lab- and field-based contract-relax (CR) and modified CR stretching on knee flexor muscle-tendon mechanics

Kay, A. D., Dixon, J., Bligh, L. D. & Blazevich, A. J., 6 Jul 2016.

Research output: Contribution to ConferenceAbstract

Open Access
File
Contracts
Mechanics
Tendons
Knee
Muscles

Effect of static and dynamic stretching during a full warm-up on athletic performance in athletes

Blazevich, A. J., Gill, N. D., Kvorning, T., Kay, A. D., Go, A., Hilton, B., Drinkwater, E. & Behm, D., 6 Jul 2016.

Research output: Contribution to ConferenceAbstract

Open Access
File
Muscle Stretching Exercises
Athletic Performance
Athletes
Sports
Muscles

Photographic Engagement With People With Dementia

Schack Thoft, D. & Ward, A., 22 Apr 2016, p. 1. 1 p.

Research output: Contribution to ConferenceAbstract

Open Access
File
dementia
experience
student
photography
video

Understanding the genomic structure of copy number variants of the low-affinity Fcγ receptor region allows confirmation of the association of FCGR3B deletion with rheumatoid arthritis

Rahbari, R., Zuccherato, L., Tischler, G., Chihota, B., Tarazona-Santos, E., Machado, L. & Hollox, E. J., 6 Dec 2016.

Research output: Contribution to ConferenceAbstract

Fc Receptors
Rheumatoid Arthritis
Alleles
Genomic Segmental Duplications
Immunoglobulin Fc Fragments
2015

A clinical trial of a DNA vaccine (SCIB1) that targets dendritic cells in vivo in fully resected melanoma patients; a vaccine to prevent disease recurrence?

Durrant, L. G., Ottensmeier, C. H., Mulatero, C., Lorigan, P., Plummer, R., Cunnell, M., Metheringham, R., Brentville, V., Machado, L., Daniels, I., Hannaman, D. & Patel, P. M., 6 Oct 2015.

Research output: Contribution to ConferenceAbstract

Open Access
File
DNA Vaccines
Dendritic Cells
Melanoma
Vaccines
Clinical Trials

Acute effects of contract-relax stretching, static stretching and isometric contractions on muscle-tendon mechanics

Kay, A. D., Husbands-Beasley, J. & Blazevich, A. J., 13 Jul 2015.

Research output: Contribution to ConferenceAbstract

Open Access
File
Muscle Stretching Exercises
Isometric Contraction
Contracts
Articular Range of Motion
Mechanics

Acute effects of muscle length during the contraction phase of contract-relax stretching on muscle-tendon mechanics

Kay, A. D., Dods, S. & Blazevich, A. J., 24 Jun 2015.

Research output: Contribution to ConferenceAbstract

Open Access
File
Contracts
Mechanics
Tendons
Articular Range of Motion
Muscles

Biomechanical effects of elastic bands, chains and free-weight resistance on submaximal back squat exercise

Mina, M. A., Blazevich, A. J., Giakas, G., Draper, N. & Kay, A. D., 24 Jun 2015.

Research output: Contribution to ConferenceAbstract

Open Access
File
Quadriceps Muscle
Electromyography
Exercise
Weights and Measures
Biomechanical Phenomena

G.P.147 - Outcome measures for Duchenne muscular dystrophy from ambulant to non-ambulant: implications for clinical trials

Ricotti, V., Eagle, M., Butler, J., Decostre, V., Deborah, R., Moraux, A., Anthony, K., Sleby, V., Guglieri, M., Van der Holst, M., Jansen, M., Morgan, J., de Groot, I., Niks, E., Verschuuren, J., Servais, L., Hogrel, J. Y., Voit, T., Straub, V. & Muntoni, F., 1 Oct 2015, In : Neuromuscular Disorders. 25, Supp 2

Research output: Contribution to JournalAbstract

Open Access
File
Duchenne Muscular Dystrophy
Outcome Assessment (Health Care)
Clinical Trials
Natural History
Walking

G.P.228 - Micro RNA profile associated with the dystrophin level in Becker muscular dystrophy

Zaharieva, I., Cirak, S., Anthony, K., Feng, L., Tasca, G., Ferlini, A., Morgan, J. & Muntoni, F., 1 Oct 2015, In : Neuromuscular Disorders. 25, Supp 2

Research output: Contribution to JournalAbstract

Open Access
File
Dystrophin
Duchenne Muscular Dystrophy
MicroRNAs
Frameshift Mutation
Reading Frames

Responses to an isometric leg-exercise test predicts sex-specific training-induced reductions in resting blood pressure after isometric leg training

Baross, A., Milne, K., McGowan, C. & Swaine, I. L., 26 Jul 2015, p. 1.

Research output: Contribution to ConferenceAbstract

Open Access
File
Exercise Test
Leg
Exercise
Blood Pressure

Using Bilateral and Unilateral Exercise to Better Understand the Blood Pressure Lowering Effects of Isometric Handgrip Training: Preliminary Findings

Pearl, M., Zokvic, M., Somani, Y., Badrov, M., Hanik, S-A., Baross, A., Swaine, I. L., Milne, K. & McGowan, C., 14 Oct 2015, p. 1.

Research output: Contribution to ConferenceAbstract

Open Access
File
Constriction
Dilatation
Extremities
Exercise
Blood Pressure
2014

Abstract CT331: Phase I/II trial of a novel antibody DNA immunotherapy, targeting CD64, in the treatment of Melanoma

Durrant, L. G., Ottensmeier, C., Lorigan, P., Mulatero, C., Plummer, R., Cunell, M., Metheringham, R. L., Brentville, V. A. & Machado, L., 1 Oct 2014.

Research output: Contribution to ConferenceAbstract

Immunotherapy
Melanoma
Antibodies
DNA
Epitopes

Establishing Equivalent Training Intensities for Isometric Bilateral-Leg and Handgrip Exercise Using the Category Ratio Scale

Baross, A., Silvey, W., McGowan, C., Milne, K. & Swaine, I. L., 4 Jul 2014, p. 1.

Research output: Contribution to ConferenceAbstract

Open Access
File
Leg
Exercise
Isometric Contraction
Analysis of Variance
Healthy Volunteers

Genomic dissection of the Fcγ receptor region in the context of monoclonal antibody therapy

Hargreaves, C., Iriyama, C., Rose-Zerilli, M., Lee, C., Potter, K., Ganderton, R., Hussain, K., Machado, L., Hollox, E. J., Coupland, S., Stackpole, M., Oates, M., Pettitt, A. R., Cragg, M. & Strefford, J., 6 Dec 2014.

Research output: Contribution to ConferenceAbstract

Fc Receptors
IgG Receptors
Paraffin
Formaldehyde
Single Nucleotide Polymorphism

High-mobility group protein 1 (HMGB1) is an independent predictor of poor survival in ovarian cancer

Machado, L., Moseley, P., Moss, R., Nolan, C., Rampage, J., Chan, S. & Durrant, L. G., 1 Jan 2014.

Research output: Contribution to ConferenceAbstract

High Mobility Group Proteins
HMGB1 Protein
Ovarian Neoplasms
Survival
Neoplasms

Isometric handgrip (IHG) training-induced reductions in resting blood pressure: Reactivity to a 2-minute handgrip task identifies responders and non-responders in young normotensive individuals

Somani, Y., Hanik, S-A., Malandruccalo, A., Freeman, S. R., Caruana, N., Badrov, M., Baross, A., Swaine, I. L., Milne, K. & McGowan, C., 22 Oct 2014, p. 1.

Research output: Contribution to ConferenceAbstract

Open Access
File
Blood Pressure
Pressure
Hand
Isometric Contraction
Immersion

Phase I trial of ImmunoBody in melanoma patients

Patel, P. M., Durrant, L. G., Ottensmeier, C., Mulatero, C., Lorigan, P., Plummer, R., Cunnell, M., Metheringham, R. L., Brentville, V. A., Machado, L., Daniels, I. & Hannaman, D., 1 Jun 2014.

Research output: Contribution to ConferenceAbstract

Melanoma
Epitopes
Vaccines
Survival
Clinical Trials

Six weeks of maximal eccentric knee extensor training affects muscle-tendon mechanics and muscle damage

Kay, A. D., Rubley, B., Talbot, C., Mina, M. A. & Blazevich, A. J., 1 Jul 2014.

Research output: Contribution to ConferenceAbstract

Open Access
File
Mechanics
Tendons
Knee
Muscles
Creatine Kinase

The influence of chain-loaded resistance on subsequent 1-RM free-weight squat performance

Mina, M. A., Blazevich, A. J., Giakas, G. & Kay, A. D., 1 Jul 2014.

Research output: Contribution to ConferenceAbstract

Open Access
File
Muscle
Chemical activation
2013

A national survey to evaluate current splinting practice for stroke survivors

Khatri, R., Logan, P., Kay, A. D. & Lehner, A. N., 1 Jun 2013.

Research output: Contribution to ConferenceAbstract

Survivors
Stroke
Upper Extremity
Aptitude
Muscle Spasticity

Assessing T cell-mediated immune response to dystrophin in the natural history of Duchenne muscular dystrophy

Anthony, K., Ricotti, V., Guglieri, M., Servais, L., Voit, T., Bushby, K., Straub, V., Morgan, J. & Muntoni, F., 2013, In : Neuromuscular Disorders.

Research output: Contribution to JournalAbstract

Dystrophin
Duchenne Muscular Dystrophy
T-Lymphocytes
Exons
Epitopes

Factors influencing maximum ROM at the ankle joint: different results from cross-sectional vs. longitudinal studies

Blazevich, A. J., Waugh, C., Cannavan, D., Fath, F., Miller, S. & Kay, A. D., 28 Jun 2013.

Research output: Contribution to ConferenceAbstract

File
Ankle Joint
Articular Range of Motion
Longitudinal Studies
Tendons
Torque

Recommendations for high intensity upper body exercise testing

Talbot, C., Kay, A. D., Walker, N. & Price, M., 1 Sep 2013.

Research output: Contribution to ConferenceAbstract

File
Exercise
Heart Rate
Oxygen
Sports
Anaerobiosis

The Effects of Training Involving Simultaneous Walking with Isometric Exercise on Resting Blood Pressure in Young Healthy Adults

Baross, A., Hodgson, D., Padfield, S. L. & Swaine, I. L., 26 Jul 2013, p. 1.

Research output: Contribution to ConferenceAbstract

Open Access
File
Walking
Young Adult
Exercise
Blood Pressure
Arterial Pressure

The influence of 6 weeks of maximal eccentric plantarflexor training on muscle-tendon mechanics

Kay, A. D., Richmond, D., Talbot, C., Mina, M. A. & Blazevich, A. J., 27 Jun 2013.

Research output: Contribution to ConferenceAbstract

File
Mechanics
Tendons
Muscles
Articular Range of Motion
Resistance Training

The influence of acute variable resistance loading on subsequent free-weight maximal squat performance

Mina, M. A., Giakas, G., Blazevich, A. J. & Kay, A. D., 1 Jun 2013.

Research output: Contribution to ConferenceAbstract

File
Quadriceps Muscle
Weights and Measures
Electromyography
Exercise
Lower Extremity
2012

A morpholino antisense oligonucleotide rescues type I and type III SMA mice

Zhou, H., Janghra, N., Anthony, K., Morgan, J. & Muntoni, F., 2012, In : Neuromuscular Disorders.

Research output: Contribution to JournalAbstract

Spinal Muscular Atrophies of Childhood
Spinal Muscular Atrophy
Morpholinos
Antisense Oligonucleotides
Motor Neurons

Biochemical and clinical variability of Becker muscular dystrophy: Predicting optimal target exons for exon skipping therapy in Duchenne muscular

Anthony, K., Arechavala-Gomeza, V., Ricotti, V., Torelli, S., Feng, L., Tasca, G., Guglieri, M., Barresi, R., Armaroli, A., Ferlini, A., Bushby, K., Straub, V., Ricci, E., Sewry, C., Morgan, J. & Muntoni, F., 2012, In : Neuromuscular Disorders.

Research output: Contribution to JournalAbstract

Duchenne Muscular Dystrophy
Dystrophin
Exons
Dystrophin-Associated Proteins
Therapeutics

Correlation of internally deleted dystrophin and dystrophin-associated protein expression with clinical severity in Becker muscular dystrophy

Anthony, K., Cirak, S., Torelli, S., Tasca, G., Feng, L., Arechavala-Gomeza, V., Armaroli, A., Guglieri, M., Straathof, C. S., Verschuuren, J. J., Aartsma-Rus, A., Helderman-Van Den Enden, P., Bushby, K., Straub, V., Sewry, C., Ferlini, A., Ricci, E., Morgan, J. & Muntoni, F., 2012, In : Neuromuscular Disorders.

Research output: Contribution to JournalAbstract

Dystrophin-Associated Proteins
Dystrophin
Duchenne Muscular Dystrophy
Exons
Clinical Trials

The early lung cancer detection initiative in Corby, Northamptonshire, UK

Campbell, J., Rogers, S., Pyer, M. & Reddy, R., 1 Dec 2012, In : International Journal of Tuberculosis and Lung Disease. 16 (12), Supp 1, p. S414 1 p.

Research output: Contribution to JournalAbstract

Open Access
File

The influence of hip angle on dorsiflexion range of motion, passive angle moment and neuromuscular reflex activity of the triceps surae

Kay, A. D., Warren, L. A. & Hammond, L. E., 4 Jul 2012.

Research output: Contribution to ConferenceAbstract

Articular Range of Motion
Reflex
Hip
Ankle
Stretch Reflex
2011

A systematic review of the effects of acute static stretch on maximal muscular performance

Kay, A. D. & Blazevich, A. J., 6 Jul 2011.

Research output: Contribution to ConferenceAbstract

Muscles
Muscle Stretching Exercises
Task Performance and Analysis
Muscle Contraction
Research

Exon skipping and dystrophin restoration in Duchenne muscular dystrophy patients after systemic phosphorodiamidate morpholino oligomer treatment

Cirak, S., Arechavala-Gomeza, V., Guglieri, M., Feng, L., Torelli, S., Anthony, K., Garralda, M. E., Wells, D. J., Dickson, G., Wood, M. J., Wilton, S. D., Straub, V., Shrewsbury, S. B., Sewry, C., Morgan, J., Bushby, K. & Muntoni, F., 2011, In : Neuromuscular Disorders.

Research output: Contribution to JournalAbstract

Morpholinos
Dystrophin
Duchenne Muscular Dystrophy
Exons
Biopsy

P07 The feasibility of exon skipping to restore the reading frame in DMD patients with duplications

kim, J., Anthony, K., cloke, V., yau, M., Abbs, S., Morgan, J. & Muntoni, F., 2011, In : Neuromuscular Disorders.

Research output: Contribution to JournalAbstract

Reading Frames
Duchenne Muscular Dystrophy
Exons
Antisense Oligonucleotides
Frameshift Mutation

Quantification of exon skipping in Duchenne muscular dystrophy by qRT-PCR

Anthony, K., Morgan, J. & Muntoni, F., 2011, In : Neuromuscular Disorders.

Research output: Contribution to JournalAbstract

Duchenne Muscular Dystrophy
Antisense Oligonucleotides
Dystrophin
Exons
Polymerase Chain Reaction