Outcomes of treatment of synovial sarcoma

Bill Robertson-Smith, Thomas McCulloch, Jackie Campbell, Karen Anthony, Robert Ashford

Research output: Contribution to ConferenceAbstractpeer-review

Abstract

Introduction
Synovial sarcoma accounts for 5% to 10% of malignant soft-tissue tumours. It occurs more commonly in males. Treatment options include surgery, radiotherapy and chemotherapy with the latter two being used in either an induction or adjuvant fashion.
We review the 15-year experience of management of synovial sarcoma patients (2000-2015) referred to the East Midlands Sarcoma Service to allow for 5-year follow-up

Methods
Patients were identified from histopathology data held at Leicester and Nottingham. Data were stored in a secure Microsoft Excel spreadsheet.

Results
97 patients (49 male) were identified, mean age 42 years (range 8 – 83 years); data were incomplete on 3 patients. 51 (53%) arose in the lower limb. Size at presentation was 38 <5cm, 29 5-10cm and 28 >10cm. 50 patients developed metastatic disease (7 presented with metastases) and 15 patients local recurrence over the course of treatment. The majority of patients were treated with surgery as the primary treatment modality although larger tumours received radiotherapy either as induction or adjuvant. Chemotherapy as a curative treatment was only used for small numbers of patients, although was more commonly used palliatively.

Discussion
Multi-modality treatment for synovial sarcomas is increasingly commonly used with a view to improving oncologic outcomes. In this unselected series of synovial sarcomas over 50% of patients relapse from the disease and appropriate targeting of those at high risk of relapse may offer a therapeutic advantage. Further work on the dataset continues to identify particular risk factors for relapse.
Original languageEnglish
Publication statusPublished - 8 Oct 2021
EventBritish Orthopaedic Oncology Society 2021 - Bristol, United Kingdom
Duration: 8 Oct 2021 → …

Conference

ConferenceBritish Orthopaedic Oncology Society 2021
Country/TerritoryUnited Kingdom
CityBristol
Period8/10/21 → …

Keywords

  • Sarcoma
  • Synovial sarcoma
  • Cancer

Cite this