Lee Machado

Personal profile

Biography

Lee is an Associate professor (Biochemistry) and Senior Fellow of the Higher Education Academy in the Faculty of Health, co-leader of the Molecular Biosciences Research group in the Physical Activity And Life Sciences Centre at the University of Northampton and Honorary Fellow in the Department of Genetics at the University of Leicester.

Lee completed an undergraduate degree at the University of Warwick and a PhD in cancer studies at the University of Birmingham. He did postdoctoral research at the Institute for Cancer Studies (Birmingham), the MRC toxicology unit (Leicester) and the Department of Genetics (Leicester) before working as a senior scientist for the cancer vaccine company, Scancell (Nottingham); Lee came to the University of Northampton as a Lecturer in 2013.

Research Interests

Lee’s research is focused on employing cellular and molecular genetic strategies to address how the host immune system responds to pathogens and cancer. The aim of this work is to increase our understanding of human health and disease and develop rational therapeutic approaches to harness the exquisite specificity and sensitivity of the immune system.

Key areas of research are:

Copy number variation of immunity genes
Tumour immunology and the development of cancer immunotherapy

Lee collaborates locally, nationally and internationally to advance his research agenda and has worked on Cancer Research UK, Medical Research Council and Wellcome Trust funded projects. He is a regular reviewer for a number of academic journals including Human Immunology, Blood, PLOSone and PLOS Genetics. He has published in high impact journals including Blood, American Journal of Human Genetics and the American Journal of Pathology and is an occasional reviewer for major funding bodies.

Supervision

Nermin Albalbeisi; Sports, Exercise and Life Science

Potential role of PAD2 in Ovarian Cancer.

Adam Gregory; Sports, Exercise and Life Science

The prevalence and persistence of antimicrobial resistance markers in anaerobic digestion plants.

Amber Hameed; Sports, Exercise and Life Science

Characterisation of the lipooligosaccharide (LOS) biosynthesis gene clusters in Campylobacter species.

Michael Naidoo; Sports, Exercise and Life Science

Doctoral Research Project.

David Young; Sports, Exercise and Life Science

Evolutionary genetic dissection of Fc receptors for IgG antibodies.

Guido Di Martino; Sports, Exercise and Life Science

Welfare issues in Italian heavy pig production.

Teaching Interests

Lee teaches and leads on the following Bioscience modules:

SLS1013 Biochemistry and Cell Biology (Teaching)
SLS1019 Introduction to Microbiology (Teaching)
SLS1020 Genetics and Molecular Biology (Module lead)
SLS2010 Health and Disease (Module lead)
SLS3003 Immunology and Health (Module Lead)
SLS3001 Health, Risk and Environment (Teaching)

Education/Academic qualification

PhD, University of Birmingham

Bachelor, University of Warwick

External positions

Visiting Fellow, The Open University

Visiting Fellow, University of Leicester

Keywords

QR180 Immunology
RC0254 Neoplasms. Tumors. Oncology (including Cancer)

Fingerprint Dive into the research topics where Lee Machado is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

T-Lymphocytes Medicine & Life Sciences

IgG Receptors Medicine & Life Sciences

Neoplasms Medicine & Life Sciences

Fc Receptors Medicine & Life Sciences

Human Herpesvirus 4 Medicine & Life Sciences

DNA Vaccines Medicine & Life Sciences

Melanoma Medicine & Life Sciences

Defensins Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Research Output 2003 2018

19 Article
19 Abstract
2 Chapter
1 Poster

High fat diet induced obesity modulates melanoma tumour microenvironment in low density lipoprotein receptor deficient LDLR-/- mouse model.

Al-Zubaidi, R., Stover, C. & Machado, L. R., 13 Sep 2018, p. 90. 1 p.

Research output: Contribution to conference types › Abstract › Research

Open Access

Tumor Microenvironment

LDL Receptors

High Fat Diet

Melanoma

Obesity

3 Downloads (Pure)

Neuropathophysiology of Duchenne muscular dystrophy: involvement of the dystrophin isoform Dp71 in cell migration and proliferation

Ash, A., Machado, L., Raleigh, S. M. & Anthony, K., 1 Apr 2018, In : Neuromuscular Disorders. 28, Sup. 1

Research output: Contribution to journal › Abstract › Research › peer-review

Open Access

File

Dystrophin

Duchenne Muscular Dystrophy

Cell Movement

Protein Isoforms

Cell Proliferation

Targeting gp100 and TRP-2 with a DNA vaccine: incorporating T cell epitopes with a human IgG1 antibody induces potent T cell responses that are associated with favourable clinical outcome in a phase I/II trial

Patel, P. M., Ottensmeier, C., Mulatero, C., Lorigan, P., Plummer, R., Pandha, H., Elsheik, S., Hadjimichael, E., Villasanti, N., Adams, S. E., Cunnell, M., Metheringham, R. L., Brentville, V. A., Machado, L., Daniels, I., Gijon, M., Hannaman, D. & Durrant, L. G., 2018, In : OncoImmunology. 7, 6, p. e1433516

Research output: Contribution to journal › Article › Research › peer-review

Open Access

File

DNA Vaccines

T-Lymphocyte Epitopes

Immunoglobulin G

T-Lymphocytes

Antibodies

Abstract 9035: An adjuvant clinical trial of SCIB1, a DNA vaccine that targets dendritic cells in vivo, in fully resected melanoma patients

Patel, P. M., Ottensmeier, C., Mulatero, C., Lorigan, P., Plummer, R., Hannaman, D., Cunnell, M., Metheringham, R. L., Brentville, V. A., Daniels, I., Machado, L. & Durrant, L. G., 31 Jan 2017.

Research output: Contribution to conference types › Abstract › Research

DNA Vaccines

Dendritic Cells

Melanoma

Clinical Trials

Epitopes

Health and wellbeing amongst older people research in Northamptonshire

Poole, H., Sixsmith, J., Parkes, J., Ward, A., Pyer, M., Campbell, J., Machado, L., Rehling, T., Youell, J., Carter, J., Oyebode, J., O’Malley, M., Anthony, K., Rogers, S., Jones, J., Siddons, L., Smith, L-A., Kay, T., Fraser, M., Score, J. & 8 others, El Khoury, L., Hameed, A., Albalbeisi, N., Durrant, L. G., Al-Zubaidi, R., Al-Rayahi, I., da Silva, K. & Taylor, J., 1 Aug 2017, In : East Midlands Research into Ageing Network (EMRAN) Discussion Paper Series. 15

Research output: Contribution to journal › Article › Research

Open Access

File

health

research practice

commitment

Values