Projects per year
Personal profile
Biography
Lee is a Professor of Molecular Medicine at the University of Northampton, where he also serves as Faculty Research & Enterprise Lead and is a Senior Fellow of the Higher Education Academy. He is a member of the Centre for Physical Activity And Life Sciences and Centre for Smart and Advanced Technologies at the University of Northampton, and is also an Honorary Fellow in the Department of Genetics and Genome Biology at the University of Leicester.
Lee received his Biochemistry undergraduate degree from the University of Warwick, MRes in Bioinformatics from the University Nottingham and completed a PhD in cancer studies at the University of Birmingham. He has done postdoctoral research at the Institute for Cancer Studies in Birmingham, the MRC toxicology unit in Leicester, and the Department of Genetics at the University of Leicester. Prior to joining the University of Northampton as a Lecturer in 2013, Lee worked as a senior scientist for the cancer vaccine company Scancell in Nottingham. He has also served as Interim Head of Sport, Exercise and Life Sciences at the University of Northampton, and has three years of experience serving on the University's Board.
Research Interests
Lee’s research is focused on employing cellular and molecular genetic strategies to address how the host immune system responds to pathogens and cancer. The aim of this work is to increase our understanding of human health and disease and develop rational therapeutic approaches to harness the exquisite specificity and sensitivity of the immune system.
Key areas of research are:
- Copy number variation of immunity genes (Fc receptors)
- Tumour immunology and the development of cancer immunotherapy
- The role of Dystrophin in cancer
Lee collaborates locally, nationally and internationally to advance his research agenda and has worked on Cancer Research UK, Medical Research Council and Wellcome Trust funded projects. He is a regular reviewer for a number of academic journals including Human Immunology, Blood, PLOSone and PLOS Genetics. He has published in high impact journals including Blood, American Journal of Human Genetics and the American Journal of Pathology and is an occasional reviewer for major funding bodies.
Supervision
- Nermin Albalbeisi; Characterising the Role of the Calcium-dependent Citrullinating Enzyme Peptidyl Arginine Deiminase 2 in Ovarian Cancer (completed)
- Amber Hameed; Characterisation of the lipooligosaccharide (LOS) biosynthesis gene clusters in Campylobacter species. (completed)
- Guido Di Martino; Welfare issues in Italian heavy pig production. (completed)
- Izzat Al- Rayahi; Role of Properdin in Tumour Growth and Cell Recruitment (completed)
- Rafah-al-Zubeidi; Obesity as a modulator of tumour microenvironment and anti- tumour responses in a mouse model (completed)
- Michael Naidoo; The role of Dystophin in Low grade glioma
- David Young; Evolutionary genetic dissection of Fc receptors for IgG antibodies.
- Mett Smart; Bacterial Growth within Endoscope Channels between Reprocessing and Use: a scientific approach
- Faz Sultana; Rapid Analysis of non-tubercular mycobacteria species (NTM) using PCR and End-Point analysis
- Lewis Waterfield; Response of Streptococcus pneumoniae to metal and oxidative stresses.
- Leanne Jones; Investigating a role for dystrophin in the tumourigenesis of head and neck cancer.
- Saul Cuttell; Effects of different forms of eccentric exercise and cryotherapy on exercise induced muscle damage and the repeat bout effect
- Sonika Divakar; Exploring the link between Duchenne muscular dystrophy and sarcoma
Teaching Interests
Lee has led or currently leads the following Bioscience modules:
- SLS1021 Fundamentals in Immunology
- SLS3003 Immunology and Health (Current)
- SLSM012 Molecular Medicine
- SLS2041 Cellular Pathology
- SLS1008 Research Skills
- SLS1013 Biochemistry and Cell Biology
- SLS1020 Genetics and Molecular Biology
- SLS2014 Techniques in Molecular Biology
- SLS2016 Biochemistry Processes of Life
- SLS2010 Health and Disease
External Roles
- Visiting fellow at the University of Leicester
- Chair of the local Governing Body (Beauchamp City Sixth Form)
Other Responsibilities
- Faculty Research & Enterprise lead
- Member of Senate
- Chair of Faculty Research & Enterprise committee
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
PhD, PhD in Cancer Studies, University of Birmingham
Bachelor, University of Warwick
External positions
Visiting Fellow, The Open University
2017 → 2018
Visiting Fellow, University of Leicester
1 Oct 2013 → …
Keywords
- QR180 Immunology
- RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Fingerprint
- 1 Similar Profiles
Collaborations and top research areas from the last five years
Projects
- 1 Active
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Investigate the value of plasma galectin-3 and RANKL measurements in predicting disease progression and skeletal complications in Multiple Myeloma
Farahani, M., Machado, L., SIVAKUMARAN, M. & Yu, L.
2/10/23 → 2/10/24
Project: Research › Charitable Funding
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A bioinformatic analysis of the Duchenne muscular dystrophy gene and associated gene variants across human cancers
Machado, L., 7 Mar 2023, 142 p.Research output: Types of Thesis › Master's Thesis
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A Survey of Machine Learning Approaches Applied to Gene Expression Analysis for Cancer Prediction
Khalsan, M., Machado, L., SALIH AL-SHAMERY, EMAN., Ajit, S., Anthony, K., Mu, M. & Opoku Agyeman, M., 18 Mar 2022, In: IEEE Access.Research output: Contribution to Journal › Article › peer-review
Open AccessFile -
Duchenne muscular dystrophy gene expression is an independent prognostic marker for IDH mutant low-grade glioma
Naidoo, M., Jones, L., Conboy, B., Hamarneh, W., D'Souza, D., Anthony, K. & Machado, L., 25 Feb 2022, In: Scientific Reports. 12, 1, 3200.Research output: Contribution to Journal › Article › peer-review
Open AccessFile -
Duchenne muscular dystrophy gene expression is an independent prognostic marker for IDH mutant low-grade glioma
Naidoo, M., Jones, L., Conboy, B., Hamarneh, W., D'Souza, D., Anthony, K. & Machado, L., 5 Sept 2022. 1 p.Research output: Contribution to Conference › Poster › peer-review
Open AccessFile -
Molecular and In Silico typing of the lipooligosaccharide biosynthesis gene cluster in Campylobacter jejuni and Campylobacter coli
Hameed, A., Ketley, J., Woodacre, A., Machado, L. & Marsden, G. L., 31 Mar 2022, In: PLoS ONE. 17, 3, e0265585.Research output: Contribution to Journal › Article › peer-review
Open AccessFile -
The effects of three different eccentric exercise modes on temporal symptoms of exercise-induced muscle damage
Cuttell, S., Baross, A., Costello, J., Machado, L. & Kay, A. D., 2 Sept 2022.Research output: Contribution to Conference › Abstract › peer-review
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Epigenetics, Exercise and the immune system
Antrobus, M., Cuttell, S. & Machado, L., 13 Jul 2021, Epigenetics of Exercise and Sports: Concepts, Methods, and Current Research : Translational Epigenetics. Raleigh, S. (ed.). Elsevier, p. 183-199 (Translational Epigenetic; vol. 25).Research output: Contribution to Book/Report › Chapter › peer-review
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Properdin is a modulator of tumour immunity in a syngeneic mouse melanoma model
Machado, L., Al-Rayahi, I. A. M. & Stover, C., 21 Jan 2021, In: Medicina. 57, 2, 8 p., 85.Research output: Contribution to Journal › Article › peer-review
Open AccessFile
Datasets
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Dataset for - 'Duchenne muscular dystrophy gene expression is an independent prognostic marker for low-grade glioma'
Anthony, K. (Creator) & Machado, L. (Creator), University of Northampton, Jul 2021
DOI: 10.24339/ae20690c-1bdf-48b0-8c5d-c88fbc40ad4a
Dataset
File -
Dataset for PLoS ONE (Campylobacter)
Machado, L. (Creator), Woodacre, A. (Contributor) & Hameed, A. (Contributor), University of Northampton, 2021
DOI: 10.24339/4685036f-6122-4e76-8b70-6110bb0ba382
Dataset
File
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Pan-cancer vaccines: breaking tolerance by targeting stress-induced post-translational modifications in tumours
Lee Machado (Examiner)
29 Jun 2023Activity: Examinations › Examination › Research
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Investigating the role of DMD in head and neck cancer
Lee Machado (Author)
25 Jan 2023Activity: Academic Talks or Presentations › Invited talk › Research
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Epigenetic regulation of CD70-CD27 pathway post allogeneic stem cell transplant in haematological malignancies
Lee Machado (Examiner)
14 Sept 2023Activity: Examinations › Examination › Research
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The Molecular Basis of Human Tendon Pathologies: Studying both Epigenetic and Global Gene Expression Profiles
Lee Machado (Examiner)
24 Oct 2023Activity: Examinations › Examination › Research
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INVESTIGATION OF THE POTENTIAL OF NATURAL PRODUCTS TO PROMOTE THE PHAGOCYTOSIS OF TUMOUR CELLS BY MACROPHAGES
Lee Machado (Examiner)
6 Nov 2023Activity: Examinations › Examination › Research
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Investigating the oral transmission of systemic monoclonal protein and its immunological impact in multiple myeloma
Lee Machado (Examiner)
14 Sept 2023Activity: Examinations › Examination › Research
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Characterisation of autophagosomes as a source of novel citrullinated antigens for use as a cancer vaccine
Lee Machado (Examiner)
24 May 2023Activity: Examinations › Examination › Research
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Comparison of repeated bout protective effect between different eccentric contraction modes
Saul Cuttell (Author), Anthony Baross (Author), Joseph Costello (Author), Lee Machado (Author) & Tony Kay (Author)
7 Jul 2023Activity: Academic Talks or Presentations › Conference Presentation
Press/Media
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New radio show for Northampton offers a fresh insight into pandemic
2/02/21
1 item of Media coverage
Press/Media