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Personal profile

Biography

Lee is an Associate professor (Biochemistry) and Senior Fellow of the Higher Education Academy in the Faculty of Arts, Science and Technology, co-leader of the Molecular Biosciences Research group in the Physical Activity And Life Sciences Centre at the University of Northampton and Honorary Fellow in the Department of Genetics and Genome Biology at the University of Leicester.

Lee completed an undergraduate degree at the University of Warwick and a PhD in cancer studies at the University of Birmingham. He did postdoctoral research at the Institute for Cancer Studies (Birmingham), the MRC toxicology unit (Leicester) and the Department of Genetics (Leicester) before working as a senior scientist for the cancer vaccine company, Scancell (Nottingham); Lee came to the University of Northampton as a Lecturer in 2013 and was Interim Head of Sport, Exercise and Life Sciences in 2017-2018 and has 3 years of University Board level experience. 

Research Interests

Lee’s research is focused on employing cellular and molecular genetic strategies to address how the host immune system responds to pathogens and cancer. The aim of this work is to increase our understanding of human health and disease and develop rational therapeutic approaches to harness the exquisite specificity and sensitivity of the immune system.

Key areas of research are:

  • Copy number variation of immunity genes
  • Tumour immunology and the development of cancer immunotherapy

Lee collaborates locally, nationally and internationally to advance his research agenda and has worked on Cancer Research UK, Medical Research Council and Wellcome Trust funded projects. He is a regular reviewer for a number of academic journals including Human Immunology, Blood, PLOSone and PLOS Genetics. He has published in high impact journals including Blood, American Journal of Human Genetics and the American Journal of Pathology and is an occasional reviewer for major funding bodies.

 

Supervision

  • Nermin Albalbeisi; Characterising the Role of the Calcium-dependent Citrullinating Enzyme Peptidyl Arginine Deiminase 2 in Ovarian Cancer (completed)
  • Adam Gregory; The prevalence and persistence of antimicrobial resistance markers in anaerobic digestion plants.
  • Amber Hameed; Characterisation of the lipooligosaccharide (LOS) biosynthesis gene clusters  in Campylobacter species. (Completed)
  • Michael Naidoo; The role of Dystophin in Low grade glioma
  • David Young; Evolutionary genetic dissection of Fc receptors for IgG antibodies.
  • Guido Di Martino; Welfare issues in Italian heavy pig production. (Completed)
  • Mett Smart;  Bacterial Growth within Endoscope Channels between Reprocessing and Use: a scientific approach
  • Faz Sultana; Rapid Analysis of non-tubercular mycobacteria species (NTM) using PCR and End-Point analysis
  • Lewis Waterfield; Response of Streptococcus pneumoniae to metal and oxidative stresses.
  • Leanne Jones; Investigating a role for dystrophin in the tumourigenesis of head and neck cancer.
  • Amanda Ash; Cell migration in the neuropathophysiology of Duchenne muscular dystrophy
  • Saul Cuttell; Effects of different forms of eccentric exercise and cryotherapy on exercise induced muscle damage and the repeat bout effect
  • Izzat Al- Rayahi;  Role of Properdin in Tumour Growth and Cell Recruitment (completed)
  • Rafah-al-Zubeidi; Obesity as a modulator of tumour microenvironment and anti- tumour responses in a mouse model (completed)

Teaching Interests

Lee has led or currently leads the following Bioscience modules:

  • SLS1008 Research Skills
  • SLS1013 Biochemistry and Cell Biology 
  • SLS1020 Genetics and Molecular Biology
  • SLS1021 Fundamentals in Immunology (current)
  • SLS2014 Techniques in Molecular Biology
  • SLS2016 Biochemistry Processes of Life
  • SLS2010 Health and Disease
  • SLS3003 Immunology and Health (Current)
  • SLSM012 Molecular Medicine (Current)

Education/Academic qualification

PhD, University of Birmingham

Bachelor, University of Warwick

External positions

Visiting Fellow, The Open University

20172018

Visiting Fellow, University of Leicester

1 Oct 2013 → …

Keywords

  • QR180 Immunology
  • RC0254 Neoplasms. Tumors. Oncology (including Cancer)

Fingerprint Dive into the research topics where Lee Machado is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

T-Lymphocytes Medicine & Life Sciences
IgG Receptors Medicine & Life Sciences
Neoplasms Medicine & Life Sciences
Fc Receptors Medicine & Life Sciences
Human Herpesvirus 4 Medicine & Life Sciences
DNA Vaccines Medicine & Life Sciences
Melanoma Medicine & Life Sciences
Defensins Medicine & Life Sciences

Research Output 2003 2018

High fat diet induced obesity modulates melanoma tumour microenvironment in low density lipoprotein receptor deficient LDLR-/- mouse model.

Al-Zubaidi, R., Stover, C. & Machado, L. R., 13 Sep 2018, p. 90. 1 p.

Research output: Contribution to ConferenceAbstract

Open Access
Tumor Microenvironment
LDL Receptors
High Fat Diet
Melanoma
Obesity
Open Access
File
Dystrophin
Duchenne Muscular Dystrophy
Cell Movement
Protein Isoforms
Cell Proliferation

Targeting gp100 and TRP-2 with a DNA vaccine: incorporating T cell epitopes with a human IgG1 antibody induces potent T cell responses that are associated with favourable clinical outcome in a phase I/II trial

Patel, P. M., Ottensmeier, C., Mulatero, C., Lorigan, P., Plummer, R., Pandha, H., Elsheik, S., Hadjimichael, E., Villasanti, N., Adams, S. E., Cunnell, M., Metheringham, R. L., Brentville, V. A., Machado, L., Daniels, I., Gijon, M., Hannaman, D. & Durrant, L. G., 2018, In : OncoImmunology. 7, 6, p. e1433516

Research output: Contribution to JournalArticle

Open Access
File
DNA Vaccines
T-Lymphocyte Epitopes
Immunoglobulin G
T-Lymphocytes
Antibodies

Abstract 9035: An adjuvant clinical trial of SCIB1, a DNA vaccine that targets dendritic cells in vivo, in fully resected melanoma patients

Patel, P. M., Ottensmeier, C., Mulatero, C., Lorigan, P., Plummer, R., Hannaman, D., Cunnell, M., Metheringham, R. L., Brentville, V. A., Daniels, I., Machado, L. & Durrant, L. G., 31 Jan 2017.

Research output: Contribution to ConferenceAbstract

DNA Vaccines
Dendritic Cells
Melanoma
Clinical Trials
Epitopes

Health and wellbeing amongst older people research in Northamptonshire

Poole, H., Sixsmith, J., Parkes, J., Ward, A., Pyer, M., Campbell, J., Machado, L., Rehling, T., Youell, J., Carter, J., Oyebode, J., O’Malley, M., Anthony, K., Rogers, S., Jones, J., Siddons, L., Smith, L-A., Kay, T., Fraser, M., Score, J. & 8 others, El Khoury, L., Hameed, A., Albalbeisi, N., Durrant, L. G., Al-Zubaidi, R., Al-Rayahi, I., da Silva, K. & Taylor, J., 1 Aug 2017, In : East Midlands Research into Ageing Network (EMRAN) Discussion Paper Series. 15

Research output: Contribution to JournalArticle

Open Access
File
health
research practice
commitment
Values

High mobility group protein B1 is a predictor of poor survival in ovarian cancer

Machado, L., Moseley, P. M., Moss, R., Deen, S., Nolan, C., Spendlove, I. & Ramage, J., 24 Nov 2017, In : Oncotarget. 8, 60

Research output: Contribution to JournalArticle

Open Access
File
High Mobility Group Proteins
Ovarian Neoplasms
Survival
Neoplasms
Kaplan-Meier Estimate

Population genetics of immune-related multilocus CNV in Native Americans

Zuccherato, L., Schneider, S., Tarazona-Santos, E., Hardwick, R. J., Berg, D., Bogle, H., Gouveia, M., Machado, L., Machado, M., Rodrigues-Soares, F., Soares-Souza, G., Togni, D., Zamudio, R., Gilman, R., Duarte, D., Hollox, E. J. & Rodrigues, M. R., 29 Mar 2017, In : Journal of the Royal Society Interface. 14, 128

Research output: Contribution to JournalArticle

Open Access
File
American Indians
population genetics
loci
population structure
assortative mating

Downregulation of the citrullinating enzyme Peptidyl-arginine deiminase type-2 in ovarian cancer indicates poor prognosis

Machado, L., Moseley, P. M., Moss, R., Deen, S., Nolan, C., Spendlove, I., Ramage, J., Chan, S. & Durrant, L. G., 6 Nov 2016.

Research output: Contribution to ConferencePoster

File
Ovarian Neoplasms
Down-Regulation
Enzymes
HMGB1 Protein
Neoplasms

Activities 2014 2019

Science (Organisational unit)

Lee Machado (Chair)
1 Oct 2019 → …

Activity: Membership of a Board, Committee, Council or NetworkMembership of committeeResearch

American Society for Microbiology

Lee Machado (Participant), Alexandra Woodacre (Participant), Gemma L Marsden (Participant), Amber Hameed (Participant)
20 Jun 201924 Jun 2019

Activity: Participating in or organising a conference or workshopParticipating in a conference or workshopResearch

File

Science (Organisational unit)

Lee Machado (Chair)
1 Oct 2019 → …

Activity: Membership of a Board, Committee, Council or NetworkMembership of committeeResearch

PhD thesis

Lee Machado (Examiner)
16 Dec 2019

Activity: ExaminationsExaminationResearch

PhD viva examination

Lee Machado (Examiner)
12 Jul 2018

Activity: ExaminationsExaminationResearch

University of Northampton (Organisational unit)

Lee Machado (Member)
1 Jul 201631 Aug 2019

Activity: Membership of a Board, Committee, Council or NetworkMembership of boardResearch

Biology Methods & Protocols (Journal)

Lee Machado (Reviewer)
May 2016 → …

Activity: Publication Peer-review and Editorial WorkEditorial workResearch

Mark Jobling

Lee Machado (Host)
26 Nov 2015

Activity: Hosting a visitorHosting an Academic VisitorResearch

Thesis

Characterisation of the Lipooligosaccharide biosynthesis gene cluster in Campylobacter species.

Author: Hameed, A., 30 Oct 2019

Supervisor: Machado, L. (Supervisor), Marsden, G. L. (External person) (Supervisor) & Woodacre, A. (Supervisor)

Student thesis: Doctoral Thesis

Characterising the Role of the Calcium-dependent Citrullinating Enzyme Peptidyl Arginine Deiminase 2 in Ovarian Cancer

Author: Albalbeisi, N., Oct 2019

Supervisor: Livingstone, I. (Supervisor), Machado, L. (Supervisor) & Anthony, K. (Supervisor)

Student thesis: Doctoral Thesis

Obesity as a modulator of tumour microenvironment and anti-tumour responses in a mouse model

Author: Oday Hessian Al-Zubaidi, R., 9 Dec 2019

Supervisor: Stover, C. (External person) (Supervisor) & Machado, L. (Supervisor)

Student thesis: Doctoral Thesis

Role of Properdin in Tumour Growth and Cell Recruitment

Author: Al-Rayahi, I. A. M. & Machado, L. R., 23 Jun 2017

Supervisor: Stover, C. (External person) (Supervisor), Machado, L. R. (Supervisor) & Browning, M. (External person) (Supervisor)

Student thesis: Doctoral Thesis