Creation of a large deletion mutant in Campylobacter jejuni reveals the lipooligosaccharide gene cluster is not required for viability

Gemma L Marsden; J Li; P H Everest; A J Lawson; J M Ketley

doi:10.1128/JB.01397-08

Creation of a large deletion mutant in Campylobacter jejuni reveals the lipooligosaccharide gene cluster is not required for viability

Gemma L Marsden, J Li, P H Everest, A J Lawson, J M Ketley

University of Northampton

Research output: Contribution to Journal › Article › peer-review

Abstract

Deletion of the lipooligosaccharide biosynthesis region (Cj1132c to Cj1152c) from the genome of Campylobacter jejuni NCTC11168 shows that the core is not required for viability. The mutant was attenuated for growth and has increased sensitivity to antibiotics and detergents. Natural transformation and invasion of cultured host cells was abolished.

Original language	English
Pages (from-to)	2392–2399
Number of pages	7
Journal	Journal of Bacteriology
Volume	191
Issue number	7
DOIs	https://doi.org/10.1128/JB.01397-08
Publication status	Published - 30 Jan 2009

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title = "Creation of a large deletion mutant in Campylobacter jejuni reveals the lipooligosaccharide gene cluster is not required for viability",

abstract = "Deletion of the lipooligosaccharide biosynthesis region (Cj1132c to Cj1152c) from the genome of Campylobacter jejuni NCTC11168 shows that the core is not required for viability. The mutant was attenuated for growth and has increased sensitivity to antibiotics and detergents. Natural transformation and invasion of cultured host cells was abolished.",

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AU - Marsden, Gemma L

AU - Li, J

AU - Everest, P H

AU - Lawson, A J

AU - Ketley, J M

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AB - Deletion of the lipooligosaccharide biosynthesis region (Cj1132c to Cj1152c) from the genome of Campylobacter jejuni NCTC11168 shows that the core is not required for viability. The mutant was attenuated for growth and has increased sensitivity to antibiotics and detergents. Natural transformation and invasion of cultured host cells was abolished.

U2 - 10.1128/JB.01397-08

DO - 10.1128/JB.01397-08

M3 - Article

SN - 0021-9193

VL - 191

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EP - 2399

JO - Journal of Bacteriology

JF - Journal of Bacteriology

IS - 7

ER -

Creation of a large deletion mutant in Campylobacter jejuni reveals the lipooligosaccharide gene cluster is not required for viability

Abstract

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