Creation of a large deletion mutant in Campylobacter jejuni reveals the lipooligosaccharide gene cluster is not required for viability

Gemma L Marsden, J Li, P H Everest, A J Lawson, J M Ketley

Research output: Contribution to journalArticle

Abstract

Deletion of the lipooligosaccharide biosynthesis region (Cj1132c to Cj1152c) from the genome of Campylobacter jejuni NCTC11168 shows that the core is not required for viability. The mutant was attenuated for growth and has increased sensitivity to antibiotics and detergents. Natural transformation and invasion of cultured host cells was abolished.
Original languageEnglish
Pages (from-to)2392–2399
Number of pages7
JournalJournal of Bacteriology
Volume191
Issue number7
DOIs
Publication statusPublished - 30 Jan 2009

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Campylobacter jejuni
Multigene Family
Detergents
Cultured Cells
Genome
Anti-Bacterial Agents
Growth
lipid-linked oligosaccharides

Cite this

Marsden, Gemma L ; Li, J ; Everest, P H ; Lawson, A J ; Ketley, J M. / Creation of a large deletion mutant in Campylobacter jejuni reveals the lipooligosaccharide gene cluster is not required for viability. In: Journal of Bacteriology. 2009 ; Vol. 191, No. 7. pp. 2392–2399.
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Creation of a large deletion mutant in Campylobacter jejuni reveals the lipooligosaccharide gene cluster is not required for viability. / Marsden, Gemma L; Li, J; Everest, P H; Lawson, A J; Ketley, J M.

In: Journal of Bacteriology, Vol. 191, No. 7, 30.01.2009, p. 2392–2399.

Research output: Contribution to journalArticle

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