Regional gray matter volume and anxiety-related traits interact to predict somatic complaints in a non-clinical sample

D Wei, X Du, W Li, Q Chen, H Li, X Hao, L Zhang, G Hitchman, Q Zhang, J Qiu

Research output: Contribution to JournalArticle

Abstract

Somatic complaints can be important features of an individual’s expression of anxiety. Anxiety-related traits are also risk factors for somatic symptoms. However, it is not known which neuroanatomical mechanisms may be responsible for this relationship. In this study, our first step was to use voxel-based morphometry (VBM) approaches to investigate the neuroanatomical basis underlying somatic complaints in a large sample of healthy subjects. We found a significant positive correlation between somatic complaints and parahippocampal gyrus (PHG) volume adjacent to the entorhinal cortex. Further analysis revealed that the interaction between PHG volume/entorhinal cortex and neuroticism-anxiety (N-Anx) predicted somatic complaints. Specifically, somatic complaints were associated with higher N-Anx for individuals with increased PHG volume. These findings suggest that increased PHG volume and higher trait anxiety can predict vulnerability to somatic complaints in the general population.
Original languageEnglish
Pages (from-to)122–128
Number of pages7
JournalSocial Cognitive and Affective Neuroscience
Volume10
Issue number1
DOIs
Publication statusPublished - 11 Mar 2014

Fingerprint

Parahippocampal Gyrus
Anxiety
Entorhinal Cortex
Healthy Volunteers
Gray Matter
Population
Neuroticism

Keywords

  • Anxiety
  • Somatic complaints
  • Somatization
  • Neuroticism
  • Voxel-based morphometry (VBM)

Cite this

@article{8d02517fc0824a699832b558468fa99f,
title = "Regional gray matter volume and anxiety-related traits interact to predict somatic complaints in a non-clinical sample",
abstract = "Somatic complaints can be important features of an individual’s expression of anxiety. Anxiety-related traits are also risk factors for somatic symptoms. However, it is not known which neuroanatomical mechanisms may be responsible for this relationship. In this study, our first step was to use voxel-based morphometry (VBM) approaches to investigate the neuroanatomical basis underlying somatic complaints in a large sample of healthy subjects. We found a significant positive correlation between somatic complaints and parahippocampal gyrus (PHG) volume adjacent to the entorhinal cortex. Further analysis revealed that the interaction between PHG volume/entorhinal cortex and neuroticism-anxiety (N-Anx) predicted somatic complaints. Specifically, somatic complaints were associated with higher N-Anx for individuals with increased PHG volume. These findings suggest that increased PHG volume and higher trait anxiety can predict vulnerability to somatic complaints in the general population.",
keywords = "Anxiety, Somatic complaints, Somatization, Neuroticism, Voxel-based morphometry (VBM)",
author = "D Wei and X Du and W Li and Q Chen and H Li and X Hao and L Zhang and G Hitchman and Q Zhang and J Qiu",
year = "2014",
month = "3",
day = "11",
doi = "10.1093/scan/nsu033",
language = "English",
volume = "10",
pages = "122–128",
journal = "Social Cognitive and Affective Neuroscience",
issn = "1749-5024",
publisher = "Oxford University Press",
number = "1",

}

Regional gray matter volume and anxiety-related traits interact to predict somatic complaints in a non-clinical sample. / Wei, D; Du, X; Li, W; Chen, Q; Li, H; Hao, X; Zhang, L; Hitchman, G; Zhang, Q; Qiu, J.

In: Social Cognitive and Affective Neuroscience, Vol. 10, No. 1, 11.03.2014, p. 122–128.

Research output: Contribution to JournalArticle

TY - JOUR

T1 - Regional gray matter volume and anxiety-related traits interact to predict somatic complaints in a non-clinical sample

AU - Wei, D

AU - Du, X

AU - Li, W

AU - Chen, Q

AU - Li, H

AU - Hao, X

AU - Zhang, L

AU - Hitchman, G

AU - Zhang, Q

AU - Qiu, J

PY - 2014/3/11

Y1 - 2014/3/11

N2 - Somatic complaints can be important features of an individual’s expression of anxiety. Anxiety-related traits are also risk factors for somatic symptoms. However, it is not known which neuroanatomical mechanisms may be responsible for this relationship. In this study, our first step was to use voxel-based morphometry (VBM) approaches to investigate the neuroanatomical basis underlying somatic complaints in a large sample of healthy subjects. We found a significant positive correlation between somatic complaints and parahippocampal gyrus (PHG) volume adjacent to the entorhinal cortex. Further analysis revealed that the interaction between PHG volume/entorhinal cortex and neuroticism-anxiety (N-Anx) predicted somatic complaints. Specifically, somatic complaints were associated with higher N-Anx for individuals with increased PHG volume. These findings suggest that increased PHG volume and higher trait anxiety can predict vulnerability to somatic complaints in the general population.

AB - Somatic complaints can be important features of an individual’s expression of anxiety. Anxiety-related traits are also risk factors for somatic symptoms. However, it is not known which neuroanatomical mechanisms may be responsible for this relationship. In this study, our first step was to use voxel-based morphometry (VBM) approaches to investigate the neuroanatomical basis underlying somatic complaints in a large sample of healthy subjects. We found a significant positive correlation between somatic complaints and parahippocampal gyrus (PHG) volume adjacent to the entorhinal cortex. Further analysis revealed that the interaction between PHG volume/entorhinal cortex and neuroticism-anxiety (N-Anx) predicted somatic complaints. Specifically, somatic complaints were associated with higher N-Anx for individuals with increased PHG volume. These findings suggest that increased PHG volume and higher trait anxiety can predict vulnerability to somatic complaints in the general population.

KW - Anxiety

KW - Somatic complaints

KW - Somatization

KW - Neuroticism

KW - Voxel-based morphometry (VBM)

U2 - 10.1093/scan/nsu033

DO - 10.1093/scan/nsu033

M3 - Article

C2 - 24622213

VL - 10

SP - 122

EP - 128

JO - Social Cognitive and Affective Neuroscience

JF - Social Cognitive and Affective Neuroscience

SN - 1749-5024

IS - 1

ER -