Etiologic factors in the development of medial tibial stress syndrome: a review of the literature

Jo L Tweed, Steven J Avil, Jackie Campbell, Mike R Barnes

Research output: Contribution to JournalArticlepeer-review


Background: Medial tibial stress syndrome is a type of exercise-induced leg pain that is common in recreational and competitive athletes. Although various studies have attempted to find the exact pathogenesis of this common condition, it remains unknown. Methods: Various theories in literature from 1976 to 2006 were reviewed using key words. Results: Until recently, inflammation of the periosteum due to excessive traction was thought to be the most likely cause of medial tibial stress syndrome. This periostitis has been hypothesized by some authors to be caused by the tearing away of the muscle fibers at the muscle-bone interface, although there are several suggestions as to which, if any, muscle is responsible. Conclusions: Recent studies have supported the view that medial tibial stress syndrome is not an inflammatory process of the periosteum but instead a stress reaction of bone that has become painful. (J Am Podiatr Med Assoc 98(2): 107–111, 2008)
Original languageEnglish
Pages (from-to)107-111
Number of pages5
JournalJournal of the American Podiatric Medical Association
Issue number2
Publication statusPublished - 1 Mar 2008


  • Etiology
  • Medial tibial stress syndrome
  • Literature review


Dive into the research topics of 'Etiologic factors in the development of medial tibial stress syndrome: a review of the literature'. Together they form a unique fingerprint.

Cite this