Potential application of gelatin scaffolds prepared through in situ gas foaming in skin tissue engineering

Seyed Ali Poursamar, Javad Hatami, Alexander N Lehner, Claudia L da Silva, Frederico Castelo Ferreira, A Paula M Antunes

Research output: Contribution to JournalArticle

Abstract

Gelatin’s excellent foaming ability allows the application of in situ gas foaming as a preparation technique for porous scaffold development. Here, a new iterative experimental design for in situ gas foaming method is reported. The prepared scaffolds were studied for applying the findings to the future skin tissue engineering scaffolds. The thermal stability, mechanical properties, and pore structure of the scaffolds are reported and their degradation resistance by using collagenase enzyme and their cytotoxicity by using fibroblasts were studied. The results of this study demonstrated that gas foaming method can be modified to produce an interconnected porous structure with enhanced mechanical properties.
Original languageEnglish
Pages (from-to)315-322
Number of pages8
JournalInternational Journal of Polymeric Materials and Polymeric Biomaterials
Volume65
Issue number6
DOIs
Publication statusPublished - 8 Jan 2016

Keywords

  • Gelatin
  • cytotoxicity
  • gas foaming
  • tensile strength
  • wound dressing

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