Potential application of gelatin scaffolds prepared through in situ gas foaming in skin tissue engineering

Seyed Ali Poursamar; Javad Hatami; Alexander N Lehner; Claudia L da Silva; Frederico Castelo Ferreira; A Paula M Antunes

doi:10.1080/00914037.2015.1119688

Potential application of gelatin scaffolds prepared through in situ gas foaming in skin tissue engineering

Seyed Ali Poursamar, Javad Hatami, Alexander N Lehner, Claudia L da Silva, Frederico Castelo Ferreira, A Paula M Antunes

Research output: Contribution to Journal › Article › peer-review

Abstract

Gelatin’s excellent foaming ability allows the application of in situ gas foaming as a preparation technique for porous scaffold development. Here, a new iterative experimental design for in situ gas foaming method is reported. The prepared scaffolds were studied for applying the findings to the future skin tissue engineering scaffolds. The thermal stability, mechanical properties, and pore structure of the scaffolds are reported and their degradation resistance by using collagenase enzyme and their cytotoxicity by using fibroblasts were studied. The results of this study demonstrated that gas foaming method can be modified to produce an interconnected porous structure with enhanced mechanical properties.

Original language	English
Pages (from-to)	315-322
Number of pages	8
Journal	International Journal of Polymeric Materials and Polymeric Biomaterials
Volume	65
Issue number	6
DOIs	https://doi.org/10.1080/00914037.2015.1119688
Publication status	Published - 8 Jan 2016

Keywords

Gelatin
cytotoxicity
gas foaming
tensile strength
wound dressing

Access to Document

10.1080/00914037.2015.1119688

Poursamar_etal_TFO_2016_Potential_application_of_gelatin_scaffolds_prepared_through_in_situ_gas_foaming_in_skin_tissue_engineeringAccepted author manuscript, 993 KB

Dr Alexander Lehner
- alexander.lehnernorthampton.acuk
- University of Northampton, Science - Senior Lecturer in Human Nutrition
- Centre for Physical Activity and Life Sciences
Person: Academic

Cite this

@article{155ebe27df9c46e3861e4b19e515079a,

title = "Potential application of gelatin scaffolds prepared through in situ gas foaming in skin tissue engineering",

abstract = "Gelatin{\textquoteright}s excellent foaming ability allows the application of in situ gas foaming as a preparation technique for porous scaffold development. Here, a new iterative experimental design for in situ gas foaming method is reported. The prepared scaffolds were studied for applying the findings to the future skin tissue engineering scaffolds. The thermal stability, mechanical properties, and pore structure of the scaffolds are reported and their degradation resistance by using collagenase enzyme and their cytotoxicity by using fibroblasts were studied. The results of this study demonstrated that gas foaming method can be modified to produce an interconnected porous structure with enhanced mechanical properties.",

keywords = "Gelatin, cytotoxicity, gas foaming, tensile strength, wound dressing",

author = "Poursamar, {Seyed Ali} and Javad Hatami and Lehner, {Alexander N} and {da Silva}, {Claudia L} and Ferreira, {Frederico Castelo} and Antunes, {A Paula M}",

year = "2016",

month = jan,

day = "8",

doi = "10.1080/00914037.2015.1119688",

language = "English",

volume = "65",

pages = "315--322",

journal = "International Journal of Polymeric Materials and Polymeric Biomaterials",

issn = "0091-4037",

publisher = "Taylor & Francis",

number = "6",

}

TY - JOUR

T1 - Potential application of gelatin scaffolds prepared through in situ gas foaming in skin tissue engineering

AU - Poursamar, Seyed Ali

AU - Hatami, Javad

AU - Lehner, Alexander N

AU - da Silva, Claudia L

AU - Ferreira, Frederico Castelo

AU - Antunes, A Paula M

PY - 2016/1/8

Y1 - 2016/1/8

N2 - Gelatin’s excellent foaming ability allows the application of in situ gas foaming as a preparation technique for porous scaffold development. Here, a new iterative experimental design for in situ gas foaming method is reported. The prepared scaffolds were studied for applying the findings to the future skin tissue engineering scaffolds. The thermal stability, mechanical properties, and pore structure of the scaffolds are reported and their degradation resistance by using collagenase enzyme and their cytotoxicity by using fibroblasts were studied. The results of this study demonstrated that gas foaming method can be modified to produce an interconnected porous structure with enhanced mechanical properties.

AB - Gelatin’s excellent foaming ability allows the application of in situ gas foaming as a preparation technique for porous scaffold development. Here, a new iterative experimental design for in situ gas foaming method is reported. The prepared scaffolds were studied for applying the findings to the future skin tissue engineering scaffolds. The thermal stability, mechanical properties, and pore structure of the scaffolds are reported and their degradation resistance by using collagenase enzyme and their cytotoxicity by using fibroblasts were studied. The results of this study demonstrated that gas foaming method can be modified to produce an interconnected porous structure with enhanced mechanical properties.

KW - Gelatin

KW - cytotoxicity

KW - gas foaming

KW - tensile strength

KW - wound dressing

U2 - 10.1080/00914037.2015.1119688

DO - 10.1080/00914037.2015.1119688

M3 - Article

SN - 0091-4037

VL - 65

SP - 315

EP - 322

JO - International Journal of Polymeric Materials and Polymeric Biomaterials

JF - International Journal of Polymeric Materials and Polymeric Biomaterials

IS - 6

ER -

Potential application of gelatin scaffolds prepared through in situ gas foaming in skin tissue engineering

Abstract

Keywords

Access to Document

Fingerprint

Profiles

Dr Alexander Lehner

Cite this