Potential application of gelatin scaffolds prepared through in situ gas foaming in skin tissue engineering

Seyed Ali Poursamar, Javad Hatami, Alexander N Lehner, Claudia L da Silva, Frederico Castelo Ferreira, A Paula M Antunes

Research output: Contribution to journalArticle

Abstract

Gelatin’s excellent foaming ability allows the application of in situ gas foaming as a preparation technique for porous scaffold development. Here, a new iterative experimental design for in situ gas foaming method is reported. The prepared scaffolds were studied for applying the findings to the future skin tissue engineering scaffolds. The thermal stability, mechanical properties, and pore structure of the scaffolds are reported and their degradation resistance by using collagenase enzyme and their cytotoxicity by using fibroblasts were studied. The results of this study demonstrated that gas foaming method can be modified to produce an interconnected porous structure with enhanced mechanical properties.
Original languageEnglish
Pages (from-to)315-322
Number of pages8
JournalInternational Journal of Polymeric Materials and Polymeric Biomaterials
Volume65
Issue number6
DOIs
Publication statusPublished - 8 Jan 2016

Fingerprint

Gas foaming
Gelatin
Scaffolds (biology)
Tissue engineering
Skin
Tissue Scaffolds
Mechanical properties
Collagenases
Fibroblasts
Cytotoxicity
Pore structure
Scaffolds
Design of experiments
Thermodynamic stability
Degradation
Enzymes

Keywords

  • Gelatin
  • cytotoxicity
  • gas foaming
  • tensile strength
  • wound dressing

Cite this

Poursamar, Seyed Ali ; Hatami, Javad ; Lehner, Alexander N ; da Silva, Claudia L ; Ferreira, Frederico Castelo ; Antunes, A Paula M. / Potential application of gelatin scaffolds prepared through in situ gas foaming in skin tissue engineering. In: International Journal of Polymeric Materials and Polymeric Biomaterials. 2016 ; Vol. 65, No. 6. pp. 315-322.
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Potential application of gelatin scaffolds prepared through in situ gas foaming in skin tissue engineering. / Poursamar, Seyed Ali; Hatami, Javad; Lehner, Alexander N; da Silva, Claudia L; Ferreira, Frederico Castelo; Antunes, A Paula M.

In: International Journal of Polymeric Materials and Polymeric Biomaterials, Vol. 65, No. 6, 08.01.2016, p. 315-322.

Research output: Contribution to journalArticle

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T1 - Potential application of gelatin scaffolds prepared through in situ gas foaming in skin tissue engineering

AU - Poursamar, Seyed Ali

AU - Hatami, Javad

AU - Lehner, Alexander N

AU - da Silva, Claudia L

AU - Ferreira, Frederico Castelo

AU - Antunes, A Paula M

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KW - Gelatin

KW - cytotoxicity

KW - gas foaming

KW - tensile strength

KW - wound dressing

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