TY - JOUR
T1 - The Activity and Polymorphism of the PON1 in Patients with Chronic Liver Disease
T2 - a Systematic Review and Meta-analysis
AU - Salari, Nader
AU - Kazeminia, Mohsen
AU - Mansouri, Kamran
AU - Hosseinian-Far, Amin
AU - Mohammadi, Masoud
N1 - © 2021. Springer Science+Business Media, LLC, part of Springer Nature.
PY - 2021/8/31
Y1 - 2021/8/31
N2 - Background: Liver
diseases are among the ten deadliest diseases in the world. Measuring PON1 is a
test to assess the degree of liver disorder. There are several preliminary
studies on the rate of PON1 activity in people with liver disease, and there
are differences between the results of these studies, therefore, the aim of
this research work is to determine the level of PON1 activity in people with
liver disease using meta-analysis.
Method: The
study searched to select articles that were published electronically from 2002
to 2020, in national and international databases of SID, MagIran, Embase,
ScienceDirect, Scopus, PubMed and Web of Science (WoS).
Results: Among
the articles included in the meta-analysis, the samples in the case (patients)
and control groups were 807 and 2276 respectively. The mean activity of PON1 in
individuals with liver disease in the case and control groups were 142.06 ± 7.7
and 272.19 ± 39.6 respectively, and this was statistically significant (P
<0.05). The mean difference analysis highlights a difference of -2.75 ± 0.48
between the patient and control groups, indicating that liver disease
significantly reduces PON1 activity.
Conclusion: The
results of this study demonstrate that the polynomorphism of the PON1 is
associated with an increased risk of liver disease, with lower levels of PON1
activity in people with liver disease than in healthy patients and this
decrease was more in patients with liver cirrhosis than in other liver
diseases. Given the importance of this gene's activity, studies such as this
could provide a promising path for better drug design and treatment in future.
AB - Background: Liver
diseases are among the ten deadliest diseases in the world. Measuring PON1 is a
test to assess the degree of liver disorder. There are several preliminary
studies on the rate of PON1 activity in people with liver disease, and there
are differences between the results of these studies, therefore, the aim of
this research work is to determine the level of PON1 activity in people with
liver disease using meta-analysis.
Method: The
study searched to select articles that were published electronically from 2002
to 2020, in national and international databases of SID, MagIran, Embase,
ScienceDirect, Scopus, PubMed and Web of Science (WoS).
Results: Among
the articles included in the meta-analysis, the samples in the case (patients)
and control groups were 807 and 2276 respectively. The mean activity of PON1 in
individuals with liver disease in the case and control groups were 142.06 ± 7.7
and 272.19 ± 39.6 respectively, and this was statistically significant (P
<0.05). The mean difference analysis highlights a difference of -2.75 ± 0.48
between the patient and control groups, indicating that liver disease
significantly reduces PON1 activity.
Conclusion: The
results of this study demonstrate that the polynomorphism of the PON1 is
associated with an increased risk of liver disease, with lower levels of PON1
activity in people with liver disease than in healthy patients and this
decrease was more in patients with liver cirrhosis than in other liver
diseases. Given the importance of this gene's activity, studies such as this
could provide a promising path for better drug design and treatment in future.
KW - Liver diseases
KW - Meta-analysis
KW - PON1
U2 - 10.1007/s12029-021-00699-7
DO - 10.1007/s12029-021-00699-7
M3 - Review Article
C2 - 34467517
SN - 1941-6628
JO - Journal of Gastrointestinal Cancer
JF - Journal of Gastrointestinal Cancer
ER -