Fcγ receptors: genetic variation, function, and disease

Chantal E Hargreaves, Matthew J J Rose-Zerilli, Lee Machado, Chisako Iriyama, Edward J Hollox, Mark S Cragg, Jonathan C Strefford

Research output: Contribution to JournalArticle

Abstract

Fcγ receptors (FcγRs) are key immune receptors responsible for the effective control of both humoral and innate immunity and are central to maintaining the balance between generating appropriate responses to infection and preventing autoimmunity. When this balance is lost, pathology results in increased susceptibility to cancer, autoimmunity, and infection. In contrast, optimal FcγR engagement facilitates effective disease resolution and response to monoclonal antibody immunotherapy. The underlying genetics of the FcγR gene family are a central component of this careful balance. Complex in humans and generated through ancestral duplication events, here we review the evolution of the gene family in mammals, the potential importance of copy number, and functionally relevant single nucleotide polymorphisms, as well as discussing current approaches and limitations when exploring genetic variation in this region.
Original languageEnglish
Pages (from-to)1-19
Number of pages19
JournalImmunological Reviews
Volume268
Issue number1
DOIs
Publication statusPublished - 26 Oct 2015

Keywords

  • Fc receptors
  • genetics
  • immunotherapy
  • antibodies

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    Hargreaves, C. E., Rose-Zerilli, M. J. J., Machado, L., Iriyama, C., Hollox, E. J., Cragg, M. S., & Strefford, J. C. (2015). Fcγ receptors: genetic variation, function, and disease. Immunological Reviews, 268(1), 1-19. https://doi.org/10.1111/imr.12341