No association between coding polymorphism within Exon 4 of the human surfactant protein B gene and pulmonary function in healthy men

Stuart M Raleigh, Benjamin M Davies, David Cleal, William J Ribbans

Research output: Contribution to journalArticleResearchpeer-review

Abstract

The coding polymorphism (rs1130866) within the surfactant protein B gene is known to associate with certain respiratory abnormalities. We investigated, using spirometry and fluorescence-based PCR, whether this variant influenced pulmonary function in healthy, nonsmoking men. We found no association of pulmonary function with genotype at the rs1130866 locus.
Original languageEnglish
JournalJournal of Physiological Sciences
Volume57
Issue number3
DOIs
Publication statusPublished - 1 Jun 2007

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Surface-Active Agents
Exons
Lung
Spirometry
Genes
Fluorescence
Genotype
Polymerase Chain Reaction
IgA receptor

Keywords

  • genotype
  • pulmonary function

Cite this

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title = "No association between coding polymorphism within Exon 4 of the human surfactant protein B gene and pulmonary function in healthy men",
abstract = "The coding polymorphism (rs1130866) within the surfactant protein B gene is known to associate with certain respiratory abnormalities. We investigated, using spirometry and fluorescence-based PCR, whether this variant influenced pulmonary function in healthy, nonsmoking men. We found no association of pulmonary function with genotype at the rs1130866 locus.",
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No association between coding polymorphism within Exon 4 of the human surfactant protein B gene and pulmonary function in healthy men. / Raleigh, Stuart M; Davies, Benjamin M; Cleal, David; Ribbans, William J.

In: Journal of Physiological Sciences, Vol. 57, No. 3, 01.06.2007.

Research output: Contribution to journalArticleResearchpeer-review

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AB - The coding polymorphism (rs1130866) within the surfactant protein B gene is known to associate with certain respiratory abnormalities. We investigated, using spirometry and fluorescence-based PCR, whether this variant influenced pulmonary function in healthy, nonsmoking men. We found no association of pulmonary function with genotype at the rs1130866 locus.

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KW - pulmonary function

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