Accepting PhD Students

PhD projects

PhD and MPhil projects are available. Current research interests and potential projects include: -Neuropathophysiology of Duchenne muscular dystrophy -RNA processing of the dystrophin gene -Exercise in Duchenne muscular dystrophy -Therapeutic targeting of dystrophin in the brain -RNA processing in neurodegeneration -Biomarkers of cognition -RNA-based gene therapy/therapeutics -Neurological cancers Please get in touch by e-mail or telephone.

Willing to speak to media

20072019
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Research Output 2007 2019

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Article
Article

Aberrant RNA processing events in neurological disorders

Anthony, K. & Gallo, J. M., 18 Jun 2010, In : Brain Research. p. 67-77 11 p.

Research output: Contribution to JournalArticle

Nervous System Diseases
RNA
Alternative Splicing
RNA Stability
Amyotrophic Lateral Sclerosis

A multicenter comparison of quantification methods for antisense oligonucleotide-induced DMD exon 51 skipping in Duchenne muscular dystrophy cell cultures

Hiller, M., Falzarano, M. S., Garcia-Jimenez, I., Sardone, V., Verheul, R. C., Popplewell, L., Anthony, K., Ruiz-Del-Yerro, E., Osman, H., Goeman, J. J., Mamchaoui, K., Dickson, G., Ferlini, A., Muntoni, F., Aartsma-Rus, A., Arechavala-Gomeza, V., Datson, N. A. & Spitali, P., 2 Oct 2018, In : PLoS ONE. 13, 10, p. 1-15 15 p.

Research output: Contribution to JournalArticle

Open Access
File
Duchenne Muscular Dystrophy
Antisense Oligonucleotides
Exons
Cell Culture Techniques
Polymerase Chain Reaction

A Novel Morpholino Oligomer Targeting ISS-N1 Improves Rescue of Severe Spinal Muscular Atrophy Transgenic Mice

Zhou, H., Janghra, N., Mitrpant, C., Dickinson, R. L., Anthony, K., Price, L., Eperon, I. C., Wilton, S. D., Morgan, J. & Muntoni, F., Mar 2013, In : Human Gene Therapy. p. 331-342 12 p.

Research output: Contribution to JournalArticle

Spinal Muscular Atrophy
Morpholinos
Transgenic Mice
Antisense Oligonucleotides
Exons

Antisense Oligonucleotide-Mediated Exon Skipping for Duchenne Muscular Dystrophy: Progress and Challenges

Arechavala-Gomeza, V., Anthony, K., Morgan, J. & Muntoni, F., 1 Jun 2012, In : Current Gene Therapy. p. 152-160 9 p.

Research output: Contribution to JournalArticle

Duchenne Muscular Dystrophy
Antisense Oligonucleotides
Exons
Dystrophin
Open Reading Frames

A UV cross-linking method combined with infrared imaging to analyse RNA–protein interactions

Malmqvist, T., Spickett, C., Gallo, J-M. & Anthony, K., 5 Jun 2017, In : Biology Methods & Protocols. 2, 1, p. 1-4 4 p., 1.

Research output: Contribution to JournalArticle

Open Access
File
Infrared imaging
Labeling
RNA
Untranslated Regions
RNA Probes

Biochemical characterization of patients with in-frame or out-of-frame DMD deletions pertinent to Exon 44 or 45 skipping

Anthony, K., Arechavala-Gomeza, V., Ricotti, V., Torelli, S., Feng, L., Janghra, N., Tasca, G., Guglieri, M., Barresi, R., Armaroli, A., Ferlini, A., Bushby, K., Straub, V., Ricci, E., Sewry, C., Morgan, J. & Muntoni, F., 1 Jan 2014, In : JAMA Neurology. 71, 1, p. 32-40 9 p.

Research output: Contribution to JournalArticle

Open Access
File
Duchenne Muscular Dystrophy
Exons
Dystrophin
Phenotype
Muscular Dystrophies

Correction of tau mis-splicing caused by FTDP-17 MAPT mutations by spliceosome-mediated RNA trans-splicing

Rodriguez-Martin, T., Anthony, K., Garcia-Blanco, M. A., Mansfield, S. G., Anderton, B. H. & Gallo, J. M., 2009, In : Human Molecular Genetics. p. 3266-3273 8 p.

Research output: Contribution to JournalArticle

Trans-Splicing
Spliceosomes
Frontotemporal Dementia
Exons
Mutation

Dystrophin Dp71 and the Neuropathophysiology of Duchenne Muscular Dystrophy

Naidoo, M. & Anthony, K., 13 Dec 2019, In : Molecular Neurobiology. p. 1-20 21 p.

Research output: Contribution to JournalArticle

Open Access
Dystrophin
Duchenne Muscular Dystrophy
Brain
Muscle
Genes

Dystrophin quantification: biological and translational research implications

Anthony, K., Arechavala-Gomeza, V., Taylor, L. E., Vulin, A., Kaminoh, Y., Torelli, S., Feng, L., Janghra, N., Bonne, G., Beuvin, M., Barresi, R., Henderson, M., Laval, S., Lourbakos, A., Campion, G., Straub, V., Voit, T., Sewry, C. A., Morgan, J. E., Flanigan, K. M. & 1 others, Muntoni, F., 25 Nov 2014, In : Neurology. 83, 22

Research output: Contribution to JournalArticle

Open Access
File
Dystrophin
Translational Medical Research
Immunohistochemistry
Western Blotting
Clinical Trials

Dystrophin quantification and clinical correlations in Becker muscular dystrophy: Implications for clinical trials

Anthony, K., Cirak, S., Torelli, S., Tasca, G., Feng, L., Arechavala-Gomeza, V., Armaroli, A., Guglieri, M., Straathof, C. S., Verschuuren, J. J., Aartsma-Rus, A., Helderman-Van Den Enden, P., Bushby, K., Straub, V., Sewry, C., Ferlini, A., Ricci, E., Morgan, J. E. & Muntoni, F., 2011, In : Brain. p. 3544-3556 13 p.

Research output: Contribution to JournalArticle

Dystrophin
Duchenne Muscular Dystrophy
Clinical Trials
Exons
Dystrophin-Associated Proteins

Exon skipping and dystrophin restoration in patients with Duchenne muscular dystrophy after systemic phosphorodiamidate morpholino oligomer treatment: An open-label, phase 2, dose-escalation study

Cirak, S., Arechavala-Gomeza, V., Guglieri, M., Feng, L., Torelli, S., Anthony, K., Abbs, S., Garralda, M. E., Bourke, J., Wells, D. J., Dickson, G., Wood, M. J., Wilton, S. D., Straub, V., Kole, R., Shrewsbury, S. B., Sewry, C., Morgan, J. E., Bushby, K. & Muntoni, F., 13 Aug 2011, In : The Lancet. p. 595-605 11 p.

Research output: Contribution to JournalArticle

Morpholinos
Dystrophin
Duchenne Muscular Dystrophy
Exons
Safety

Exon Skipping Quantification by Quantitative Reverse-Transcription Polymerase Chain Reaction in Duchenne Muscular Dystrophy Patients Treated with the Antisense Oligomer Eteplirsen

Anthony, K., Feng, L., Arechavala-Gomeza, V., Guglieri, M., Straub, V., Bushby, K., Cirak, S., Morgan, J. & Muntoni, F., Oct 2012, In : Human Gene Therapy Methods. p. 336-345 10 p.

Research output: Contribution to JournalArticle

Duchenne Muscular Dystrophy
Reverse Transcription
Exons
Polymerase Chain Reaction
Dystrophin

Expression, localization and tau exon 10 splicing activity of the brain RNA-binding protein TNRC4

Chapple, P. J., Anthony, K., Martin, T. R., Dev, A., Cooper, T. A. & Gallo, J. M., 15 Nov 2007, In : Human Molecular Genetics. p. 2760-2769 10 p.

Research output: Contribution to JournalArticle

Trinucleotide Repeats
RNA-Binding Proteins
Exons
Brain
Alternative Splicing

Health and wellbeing amongst older people research in Northamptonshire

Poole, H., Sixsmith, J., Parkes, J., Ward, A., Pyer, M., Campbell, J., Machado, L., Rehling, T., Youell, J., Carter, J., Oyebode, J., O’Malley, M., Anthony, K., Rogers, S., Jones, J., Siddons, L., Smith, L-A., Kay, T., Fraser, M., Score, J. & 8 others, El Khoury, L., Hameed, A., Albalbeisi, N., Durrant, L. G., Al-Zubaidi, R., Al-Rayahi, I., da Silva, K. & Taylor, J., 1 Aug 2017, In : East Midlands Research into Ageing Network (EMRAN) Discussion Paper Series. 15

Research output: Contribution to JournalArticle

Open Access
File
health
research practice
commitment
Values

Restoration of the dystrophin-associated glycoprotein complex after exon skipping therapy in duchenne muscular dystrophy

Cirak, S., Feng, L., Anthony, K., Arechavala-Gomeza, V., Torelli, S., Sewry, C., Morgan, J. E. & Muntoni, F., 2012, In : Molecular Therapy. p. 462-467 6 p.

Research output: Contribution to JournalArticle

Dystrophin
Duchenne Muscular Dystrophy
Exons
Glycoproteins
Nitric Oxide Synthase Type I

Tau mRNA is present in axonal RNA granules and is associated with elongation factor 1A

Malmqvist, T., Anthony, K. & Gallo, J-M., 10 Oct 2014, In : Brain Research. 1584, p. 22-27 6 p.

Research output: Contribution to JournalArticle

File
Peptide Elongation Factors
Axons
RNA
Messenger RNA
Neurons